Concise review: mesenchymal stem cells and translational medicine: emerging issues.

abstract：:The kidney is a specialized low-regenerative organ with several different types of cellular lineages; however, the identity of renal stem/progenitor cells with nephrogenic potential and their preferred niche(s) are largely unknown and debated. Most of the therapeutic approaches to kidney regeneration are based on admi...

journal_title：Stem cells translational medicine

authors： Aggarwal S,Moggio A,Bussolati B

更新日期：2013-12-01 00:00:00

abstract：:: Liver fibrosis represents the end stage of chronic liver inflammatory diseases and is defined by the abnormal accumulation of extracellular matrix in the liver. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension. Liver transplantation has been the most effective treatment for these ...

journal_title：Stem cells translational medicine

authors： Lee PH,Tu CT,Hsiao CC,Tsai MS,Ho CM,Cheng NC,Hung TM,Shih DT

更新日期：2016-11-01 00:00:00

abstract：UNLABELLED:The oral cavity possesses a diverse microflora, yet recurrent infections within healthy individuals are rare. Wound healing within the buccal mucosa is preferential, potentially because of the presence of oral mucosal lamina propria-progenitor cells (OMLP-PCs). In addition to their multipotency, OMLP-PCs dem...

journal_title：Stem cells translational medicine

authors： Board-Davies E,Moses R,Sloan A,Stephens P,Davies LC

更新日期：2015-11-01 00:00:00

abstract：:Repair of injured lungs represents a longstanding therapeutic challenge. We recently demonstrated that human and mouse embryonic lung tissue from the canalicular stage of development are enriched with lung progenitors, and that a single cell suspension of canalicular lungs can be used for transplantation, provided tha...

journal_title：Stem cells translational medicine

authors： Milman Krentsis I,Rosen C,Shezen E,Aronovich A,Nathanson B,Bachar-Lustig E,Berkman N,Assayag M,Shakhar G,Feferman T,Orgad R,Reisner Y

更新日期：2018-01-01 00:00:00

abstract：:Osteoarthritis (OA) remains an intractable clinical challenge. Few drugs are available for reversing this degenerative disease, although some promising candidates have performed well in preclinical studies. Tumor necrosis factor α (TNFα) has been identified as a crucial effector modulating OA pathogenesis. This study ...

journal_title：Stem cells translational medicine

authors： Xia Q,Zhu S,Wu Y,Wang J,Cai Y,Chen P,Li J,Heng BC,Ouyang HW,Lu P

更新日期：2015-05-01 00:00:00

abstract：:γδT cells constitute a small proportion of lymphocytes in peripheral blood. Unlike αβT cells, the anti-tumor activities are exerted through several different pathways in a MHC-unrestricted manner. Thus, immunotherapy using γδT cells is considered to be effective for various types of cancer. Occasionally, however, ex v...

journal_title：Stem cells translational medicine

authors： Watanabe D,Koyanagi-Aoi M,Taniguchi-Ikeda M,Yoshida Y,Azuma T,Aoi T

更新日期：2018-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are very attractive candidates in cell-based strategies that target inflammatory diseases. Preclinical animal studies and many clinical trials have demonstrated that human MSCs can be safely administered and that they modify the inflammatory process in the targeted injured tissue. Our lab...

journal_title：Stem cells translational medicine

authors： Waterman RS,Morgenweck J,Nossaman BD,Scandurro AE,Scandurro SA,Betancourt AM

更新日期：2012-07-01 00:00:00

abstract：:Patients with laryngeal disorders may have severe morbidity relating to swallowing, vocalization, and respiratory function, for which conventional therapies are suboptimal. A tissue-engineered approach would aim to restore the vocal folds and maintain respiratory function while limiting the extent of scarring in the r...

journal_title：Stem cells translational medicine

authors： Ansari T,Lange P,Southgate A,Greco K,Carvalho C,Partington L,Bullock A,MacNeil S,Lowdell MW,Sibbons PD,Birchall MA

更新日期：2017-02-01 00:00:00

abstract：:Cell-based therapy targeting spinal cord injury (SCI) is an attractive approach to promote functional recovery by replacing damaged tissue. We and other groups have reported the effectiveness of transplanting neural stem/progenitor cells (NS/PCs) derived from human induced pluripotent stem cells (hiPSCs) in SCI animal...

journal_title：Stem cells translational medicine

authors： Kamata Y,Isoda M,Sanosaka T,Shibata R,Ito S,Okubo T,Shinozaki M,Inoue M,Koya I,Shibata S,Shindo T,Matsumoto M,Nakamura M,Okano H,Nagoshi N,Kohyama J

更新日期：2020-11-23 00:00:00

abstract：UNLABELLED:The California Institute for Regenerative Medicine (CIRM) has invested approximately $70 million in programs targeting various orthopedic indications, including osteoporosis, bone fracture healing, vertebral compression fractures, and several others. The present article serves to outline the current state of...

journal_title：Stem cells translational medicine

authors： Littman N,Abo A

更新日期：2015-11-01 00:00:00

abstract：:Global cerebral ischemia (GCI) is the leading cause of a poor prognosis even after successful resuscitation from cardiac arrest. Therapeutic induction of hypothermia (TH) is the only proven therapy-and current standard care-for GCI after cardiac arrest; however, its application has been significantly limited owing to ...

journal_title：Stem cells translational medicine

authors： Chung TN,Kim JH,Choi BY,Chung SP,Kwon SW,Suh SW

更新日期：2015-02-01 00:00:00

abstract：:Adipose tissue-derived multipotent stromal cells (AT-MSCs) are studied as an alternative to bone marrow-derived multipotent stromal cells (BM-MSCs) for immunomodulatory treatment. In this study, we systematically compared the immunomodulatory capacities of BM-MSCs and AT-MSCs derived from age-matched donors. We found ...

journal_title：Stem cells translational medicine

authors： Melief SM,Zwaginga JJ,Fibbe WE,Roelofs H

更新日期：2013-06-01 00:00:00

abstract：UNLABELLED:: Recapitulation of endochondral ossification (ECO) (i.e., generation of marrow-containing ossicles through a cartilage intermediate) has relevance to develop human organotypic models for bone or hematopoietic cells and to engineer grafts for bone regeneration. Unlike bone marrow-derived stromal cells (also ...

journal_title：Stem cells translational medicine

authors： Osinga R,Di Maggio N,Todorov A,Allafi N,Barbero A,Laurent F,Schaefer DJ,Martin I,Scherberich A

更新日期：2016-08-01 00:00:00

abstract：:Lamin A (LMNA)-linked lipodystrophies may be either genetic (associated with LMNA mutations) or acquired (associated with the use of human immunodeficiency virus protease inhibitors [PIs]), and in both cases they share clinical features such as anomalous distribution of body fat or generalized loss of adipose tissue, ...

journal_title：Stem cells translational medicine

authors： Ruiz de Eguino G,Infante A,Schlangen K,Aransay AM,Fullaondo A,Soriano M,García-Verdugo JM,Martín AG,Rodríguez CI

更新日期：2012-04-01 00:00:00

abstract：:Stem cells are promising candidate cells for regenerative applications because they possess high proliferative capacity and the potential to differentiate into other cell types. Mesenchymal stem cells (MSCs) are easily sourced but do not retain their proliferative and multilineage differentiative capabilities after pr...

journal_title：Stem cells translational medicine

authors： Boyette LB,Creasey OA,Guzik L,Lozito T,Tuan RS

更新日期：2014-02-01 00:00:00

abstract：:Similar to the disease affecting humans, osteoarthritis (OA) is a painful musculoskeletal condition affecting 20% of the adult canine population. Several solutions have been proposed, but the results achieved to date are far from being satisfactory. New approaches, such as intra-articular delivery of cells (including ...

journal_title：Stem cells translational medicine

authors： Zeira O,Scaccia S,Pettinari L,Ghezzi E,Asiag N,Martinelli L,Zahirpour D,Dumas MP,Konar M,Lupi DM,Fiette L,Pascucci L,Leonardi L,Cliff A,Alessandri G,Pessina A,Spaziante D,Aralla M

更新日期：2018-11-01 00:00:00

abstract：:Chromaffin cells, sympathetic neurons of the dorsal ganglia, and the intermediate small intensely fluorescent cells derive from a common neural crest progenitor cell. Contrary to the closely related sympathetic nervous system, within the adult adrenal medulla a subpopulation of undifferentiated progenitor cells persis...

journal_title：Stem cells translational medicine

authors： Santana MM,Chung KF,Vukicevic V,Rosmaninho-Salgado J,Kanczkowski W,Cortez V,Hackmann K,Bastos CA,Mota A,Schrock E,Bornstein SR,Cavadas C,Ehrhart-Bornstein M

更新日期：2012-11-01 00:00:00

abstract：UNLABELLED:Histone deacetylase (HDAC) inhibitors possess therapeutic potential to reverse aberrant epigenetic changes associated with cancers, neurological diseases, and immune disorders. Unfortunately, clinical studies with some HDAC inhibitors displayed delayed cardiac adverse effects, such as atrial fibrillation and...

journal_title：Stem cells translational medicine

authors： Kopljar I,Gallacher DJ,De Bondt A,Cougnaud L,Vlaminckx E,Van den Wyngaert I,Lu HR

更新日期：2016-05-01 00:00:00

abstract：:Diabetes is a risk factor for worse outcomes following acute myocardial infarction (AMI). In this study, we tested the hypothesis that SDF-1:CXCR4 expression is compromised in post-AMI in diabetes, and that reversal of this defect can reverse the adverse effects of diabetes. Mesenchymal stem cells (MSC) isolated from ...

journal_title：Stem cells translational medicine

authors： Mayorga ME,Kiedrowski M,McCallinhart P,Forudi F,Ockunzzi J,Weber K,Chilian W,Penn MS,Dong F

更新日期：2018-01-01 00:00:00

abstract：:Strategies for musculoskeletal tissue regeneration apply adult mesenchymal stem/stromal cells (MSCs) that can be sourced from bone marrow- and lipo-aspirates. Adipose tissue-derived MSCs are more easily harvested in the large quantities required for skeletal tissue-engineering approaches, but are generally considered ...

journal_title：Stem cells translational medicine

authors： Samsonraj RM,Dudakovic A,Manzar B,Sen B,Dietz AB,Cool SM,Rubin J,van Wijnen AJ

更新日期：2018-02-01 00:00:00

abstract：:Recent reports have indicated human embryonic stem cells-derived midbrain dopamine (mDA) neurons as proper cell resources for use in Parkinson's disease (PD) therapy. Nevertheless, no detailed and systematic study has been conducted to identify which differentiation stages of mDA cells are most suitable for transplant...

journal_title：Stem cells translational medicine

authors： Qiu L,Liao MC,Chen AK,Wei S,Xie S,Reuveny S,Zhou ZD,Hunziker W,Tan EK,Oh SKW,Zeng L

更新日期：2017-09-01 00:00:00

abstract：:Breast cancer-related lymphedema (BCRL) is a debilitating late complication with a lack of treatment opportunities. Recent studies have suggested that mesenchymal stromal cells can alleviate lymphedema. Herein, we report the results from the first human pilot study with freshly isolated adipose-derived regenerative ce...

journal_title：Stem cells translational medicine

authors： Toyserkani NM,Jensen CH,Andersen DC,Sheikh SP,Sørensen JA

更新日期：2017-08-01 00:00:00

abstract：:Esophageal anastomotic leakage (EAL) is a devastating complication for esophagectomy but the available therapies are unsatisfactory. Due to the healing effects of mesenchymal stromal cells (MSCs) and supporting capability of fibrin scaffold (FS), we evaluated the efficacy of a stem-cell therapy for EAL by engrafting a...

journal_title：Stem cells translational medicine

authors： Xue X,Yan Y,Ma Y,Yuan Y,Li C,Lang X,Xu Z,Chen H,Zhang H

更新日期：2019-06-01 00:00:00

abstract：:Peripheral nerve injury presents significant therapeutic challenges for recovery of motor and sensory function in patients. Different clinical approaches exist but to date there has been no consensus on the most effective method of treatment. Here, we investigate a novel approach to peripheral nerve repair using olfac...

journal_title：Stem cells translational medicine

authors： Roche P,Alekseeva T,Widaa A,Ryan A,Matsiko A,Walsh M,Duffy GP,O'Brien FJ

更新日期：2017-10-01 00:00:00

abstract：:Owing to the rapid progress in stem cell research (SCR) and regenerative medicine (RM), society's expectation and interest in these fields are increasing. For effective communication on issues concerning SCR and RM, surveys for understanding the interests of stakeholders is essential. For this purpose, we conducted a ...

journal_title：Stem cells translational medicine

authors： Shineha R,Inoue Y,Ikka T,Kishimoto A,Yashiro Y

更新日期：2018-02-01 00:00:00

abstract：:Techniques that enable longitudinal tracking of cell fate after myocardial delivery are imperative for optimizing the efficacy of cell-based cardiac therapies. However, these approaches have been underutilized in preclinical models and clinical trials, and there is considerable demand for site-specific strategies achi...

journal_title：Stem cells translational medicine

authors： Ostrominski JW,Yada RC,Sato N,Klein M,Blinova K,Patel D,Valadez R,Palisoc M,Pittaluga S,Peng KW,San H,Lin Y,Basuli F,Zhang X,Swenson RE,Haigney M,Choyke PL,Zou J,Boehm M,Hong SG,Dunbar CE

更新日期：2020-10-01 00:00:00

abstract：:The vascular wall stores mesenchymal progenitor cells which are able to induce bone regeneration, via direct and paracrine mechanisms. Although much is known regarding perivascular cell regulation of osteoblasts, their regulation of osteoclasts, and by extension utility in states of high bone resorption, is not known....

journal_title：Stem cells translational medicine

authors： Negri S,Wang Y,Sono T,Lee S,Hsu GC,Xu J,Meyers CA,Qin Q,Broderick K,Witwer KW,Peault B,James AW

更新日期：2020-12-01 00:00:00

abstract：:Generation of desired cell types by cell conversion remains a challenge. In particular, derivation of novel cell subtypes identified by single-cell technologies will open up new strategies for cell therapies. The recent increase in the generation of single-cell RNA-sequencing (scRNA-seq) data and the concomitant incre...

journal_title：Stem cells translational medicine

authors： Ribeiro MM,Okawa S,Del Sol A

更新日期：2021-02-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) offer an effective platform for studies of human physiology and have revealed new possibilities for disease modeling at the cellular level. These cells also have the potential to be leveraged in the practice of precision medicine, including personalized drug testing. Aortic disea...

journal_title：Stem cells translational medicine

authors： Zhu K,Ma W,Li J,Zhang YS,Zhang W,Lai H,Wang C

更新日期：2021-02-01 00:00:00

abstract：:Despite approaches in regenerative medicine using stem cells, bio-engineered scaffolds, and targeted drug delivery to enhance human tissue repair, clinicians remain unable to regenerate large-scale, multi-tissue defects in situ. The study of regenerative biology using mammalian models of complex tissue regeneration of...

journal_title：Stem cells translational medicine

authors： Simkin J,Seifert AW

更新日期：2018-02-01 00:00:00