Role of SDF-1:CXCR4 in Impaired Post-Myocardial Infarction Cardiac Repair in Diabetes.

abstract：UNLABELLED:: Recapitulation of endochondral ossification (ECO) (i.e., generation of marrow-containing ossicles through a cartilage intermediate) has relevance to develop human organotypic models for bone or hematopoietic cells and to engineer grafts for bone regeneration. Unlike bone marrow-derived stromal cells (also ...

journal_title：Stem cells translational medicine

authors： Osinga R,Di Maggio N,Todorov A,Allafi N,Barbero A,Laurent F,Schaefer DJ,Martin I,Scherberich A

更新日期：2016-08-01 00:00:00

abstract：UNLABELLED:The California Institute for Regenerative Medicine (CIRM) has invested approximately $70 million in programs targeting various orthopedic indications, including osteoporosis, bone fracture healing, vertebral compression fractures, and several others. The present article serves to outline the current state of...

journal_title：Stem cells translational medicine

authors： Littman N,Abo A

更新日期：2015-11-01 00:00:00

abstract：:Adipose-derived stem cell (ADSC)-based therapy is promising for critical limb ischemia (CLI) treatment, especially in patients with diabetes. However, the therapeutic effects of diabetic ADSCs (D-ADSCs) are impaired by the diabetes, possibly through intracellular reactive oxygen species (ROS) accumulation. The objecti...

journal_title：Stem cells translational medicine

authors： Peng Z,Yang X,Qin J,Ye K,Wang X,Shi H,Jiang M,Liu X,Lu X

更新日期：2017-01-01 00:00:00

abstract：:Cancer stem cells (CSCs) are a subpopulation of tumor cells that have strong self-renewal capabilities and may contribute to the failure of conventional cancer therapies. Hence, therapeutics homing in on CSCs represent a novel and promising approach that may eradicate malignant tumors. However, the lack of information...

journal_title：Stem cells translational medicine

authors： Hu X,Cong Y,Luo HH,Wu S,Zhao LE,Liu Q,Yang Y

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Tendon or ligament tears can decrease patients' quality of life. Many therapeutic interventions are available to treat such injuries. Mesenchymal stem cells (MSCs) have been shown to be effective in treating tendon or ligament tears; however, the use of stem cell-conditioned medium (CM) requires further inve...

journal_title：Stem cells translational medicine

authors： Rhatomy S,Prasetyo TE,Setyawan R,Soekarno NR,Romaniyanto F,Sedjati AP,Sumarwoto T,Utomo DN,Suroto H,Mahyudin F,Prakoeswa CRS

更新日期：2020-08-01 00:00:00

abstract：:Despite approaches in regenerative medicine using stem cells, bio-engineered scaffolds, and targeted drug delivery to enhance human tissue repair, clinicians remain unable to regenerate large-scale, multi-tissue defects in situ. The study of regenerative biology using mammalian models of complex tissue regeneration of...

journal_title：Stem cells translational medicine

authors： Simkin J,Seifert AW

更新日期：2018-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have immunomodulatory properties and support hematopoiesis in the bone marrow (BM). To develop a new strategy not only to prevent graft-vs-host disease (GVHD) but also enhance engraftment, a phase I trial of cord blood transplantation (CBT) combined with intra-BM injection of MSCs (MSC-CB...

journal_title：Stem cells translational medicine

authors： Goto T,Murata M,Nishida T,Terakura S,Kamoshita S,Ishikawa Y,Ushijima Y,Adachi Y,Suzuki S,Kato K,Hirakawa A,Nishiwaki S,Nishio N,Takahashi Y,Kodera Y,Matsushita T,Kiyoi H

更新日期：2020-12-14 00:00:00

abstract：:Knee osteoarthritis (OA) is a leading cause of pain and disability. Although conventional treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and adipose-derived (AD) mesenchymal stromal cells (MSCs) point to the feasibility, safety, and occurrence of clinical and structural improvement ...

journal_title：Stem cells translational medicine

authors： Matas J,Orrego M,Amenabar D,Infante C,Tapia-Limonchi R,Cadiz MI,Alcayaga-Miranda F,González PL,Muse E,Khoury M,Figueroa FE,Espinoza F

更新日期：2019-03-01 00:00:00

abstract：:Steroid-induced osteonecrosis of the femoral head (ONFH) is characterized by decreased osteogenesis, angiogenesis, and increased adipogenesis. While bone tissue engineering has been widely investigated to treat ONFH, its therapeutic effects remain unsatisfactory. Therefore, further studies are required to determine op...

journal_title：Stem cells translational medicine

authors： Xu H,Wang C,Liu C,Peng Z,Li J,Jin Y,Wang Y,Guo J,Zhu L

更新日期：2021-01-13 00:00:00

abstract：:Niemann-Pick disease, type C1 (NPC1) is a familial disorder that has devastating consequences on postnatal development with multisystem effects, including neurodegeneration. There is no Food and Drug Administration-approved treatment option for NPC1; however, several potentially therapeutic compounds have been identif...

journal_title：Stem cells translational medicine

authors： Efthymiou AG,Steiner J,Pavan WJ,Wincovitch S,Larson DM,Porter FD,Rao MS,Malik N

更新日期：2015-03-01 00:00:00

abstract：:Gaucher disease (GD) is the most common lysosomal storage disease resulting from mutations in the lysosomal enzyme glucocerebrosidase (GCase). The hematopoietic abnormalities in GD include the presence of characteristic Gaucher macrophages that infiltrate patient tissues and cytopenias. At present, it is not clear whe...

journal_title：Stem cells translational medicine

authors： Sgambato JA,Park TS,Miller D,Panicker LM,Sidransky E,Lun Y,Awad O,Bentzen SM,Zambidis ET,Feldman RA

更新日期：2015-08-01 00:00:00

abstract：:Generation of desired cell types by cell conversion remains a challenge. In particular, derivation of novel cell subtypes identified by single-cell technologies will open up new strategies for cell therapies. The recent increase in the generation of single-cell RNA-sequencing (scRNA-seq) data and the concomitant incre...

journal_title：Stem cells translational medicine

authors： Ribeiro MM,Okawa S,Del Sol A

更新日期：2021-02-01 00:00:00

abstract：:The translation of stem cell-based regenerative solutions from the laboratory to the clinic is often hindered by the culture conditions used to expand cell populations. Although fetal bovine serum (FBS) is widely used, regulatory bodies and safety concerns encourage alternative, xeno-free culturing practices. In an at...

journal_title：Stem cells translational medicine

authors： Roberts SJ,Owen HC,Tam WL,Solie L,Van Cromphaut SJ,Van den Berghe G,Luyten FP

更新日期：2014-02-01 00:00:00

abstract：:An understanding of how cancer cells adapt dormancy would allow for targeted treatment. The current literature suggests that the cancer stem cells might be the major cells with the ability to become quiescent and to resist current drug treatment. The properties of cancer stem cells and healthy stem cells are functiona...

journal_title：Stem cells translational medicine

authors： Bliss SA,Greco SJ,Rameshwar P

更新日期：2014-07-01 00:00:00

abstract：:Cancer stem cells play a critical role in disease initiation and insensitivity to chemotherapy in numerous hematologic malignancies and some solid tumors, and these stem cells need to be eradicated to achieve a cure. Key to successful targeting of cancer stem cells is to identify and functionally test critical target ...

journal_title：Stem cells translational medicine

authors： Zhang H,Li S

更新日期：2019-08-01 00:00:00

abstract：:Preterm birth and its complications are the leading cause of neonatal death. The main underlying pathological mechanisms for preterm complications are disruption of the normal maturation processes within the target tissues, interrupted by premature birth. Cord blood, as a new and convenient source of stem cells, may p...

journal_title：Stem cells translational medicine

authors： Ren Z,Xu F,Zhang X,Zhang C,Miao J,Xia X,Kang M,Wei W,Ma T,Zhang Q,Lu L,Wen J,Liu G,Liu K,Wang Q,Yang J

更新日期：2020-02-01 00:00:00

abstract：:The immunomodulatory activity of mesenchymal stem/stromal cells (MSCs) to suppress innate and adaptive immune responses offers a potent cell therapy for modulating inflammation and promoting tissue regeneration. However, the inflammatory cytokine milieu plays a critical role in stimulating MSC immunomodulatory activit...

journal_title：Stem cells translational medicine

authors： Zimmermann JA,Hettiaratchi MH,McDevitt TC

更新日期：2017-01-01 00:00:00

abstract：:Cell-based therapy targeting spinal cord injury (SCI) is an attractive approach to promote functional recovery by replacing damaged tissue. We and other groups have reported the effectiveness of transplanting neural stem/progenitor cells (NS/PCs) derived from human induced pluripotent stem cells (hiPSCs) in SCI animal...

journal_title：Stem cells translational medicine

authors： Kamata Y,Isoda M,Sanosaka T,Shibata R,Ito S,Okubo T,Shinozaki M,Inoue M,Koya I,Shibata S,Shindo T,Matsumoto M,Nakamura M,Okano H,Nagoshi N,Kohyama J

更新日期：2020-11-23 00:00:00

abstract：:Adult hemoglobin composed of α- and β-globin reflects a change from expression of embryonic ε- and fetal γ-globin to adult β-globin in human erythroid cells, so-called globin switching. Human pluripotent stem cells (hPSCs) are a potential source for in vitro erythrocyte production, but they show prominent expression o...

journal_title：Stem cells translational medicine

authors： Ochi K,Takayama N,Hirose S,Nakahata T,Nakauchi H,Eto K

更新日期：2014-07-01 00:00:00

abstract：UNLABELLED:Rotator cuff tendon tear is one of the most common causes of chronic shoulder pain and disability. In this study, we investigated the therapeutic effects of ultrasound-guided human umbilical cord blood (UCB)-derived mesenchymal stem cell (MSC) injection to regenerate a full-thickness subscapularis tendon tea...

journal_title：Stem cells translational medicine

authors： Park GY,Kwon DR,Lee SC

更新日期：2015-11-01 00:00:00

abstract：:Similar to the disease affecting humans, osteoarthritis (OA) is a painful musculoskeletal condition affecting 20% of the adult canine population. Several solutions have been proposed, but the results achieved to date are far from being satisfactory. New approaches, such as intra-articular delivery of cells (including ...

journal_title：Stem cells translational medicine

authors： Zeira O,Scaccia S,Pettinari L,Ghezzi E,Asiag N,Martinelli L,Zahirpour D,Dumas MP,Konar M,Lupi DM,Fiette L,Pascucci L,Leonardi L,Cliff A,Alessandri G,Pessina A,Spaziante D,Aralla M

更新日期：2018-11-01 00:00:00

abstract：:Perivascular stem cells (PSCs) are the natural ancestors of mesenchymal stem cells (MSCs) and are the stem cells responsible for homeostasis and repair in vivo. Prospectively identified and isolated PSCs have demonstrated increased plasticity and osteogenic potential. Cells from the infrapatellar fat pad (IFP) have de...

journal_title：Stem cells translational medicine

authors： Hindle P,Khan N,Biant L,Péault B

更新日期：2017-01-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) offer an effective platform for studies of human physiology and have revealed new possibilities for disease modeling at the cellular level. These cells also have the potential to be leveraged in the practice of precision medicine, including personalized drug testing. Aortic disea...

journal_title：Stem cells translational medicine

authors： Zhu K,Ma W,Li J,Zhang YS,Zhang W,Lai H,Wang C

更新日期：2021-02-01 00:00:00

abstract：:The present first-in-human clinical trial evaluated the safety and feasibility of a newly developed and cryopreserved Cardiology Stem Cell Centre adipose-derived stromal cell (CSCC_ASC) product from healthy donors for intramyocardial injection in ten patients with ischemic heart disease and ischemic heart failure (IHF...

journal_title：Stem cells translational medicine

authors： Kastrup J,Haack-Sørensen M,Juhl M,Harary Søndergaard R,Follin B,Drozd Lund L,Mønsted Johansen E,Ali Qayyum A,Bruun Mathiasen A,Jørgensen E,Helqvist S,Jørgen Elberg J,Bruunsgaard H,Ekblond A

更新日期：2017-11-01 00:00:00

abstract：:Repair of injured lungs represents a longstanding therapeutic challenge. We recently demonstrated that human and mouse embryonic lung tissue from the canalicular stage of development are enriched with lung progenitors, and that a single cell suspension of canalicular lungs can be used for transplantation, provided tha...

journal_title：Stem cells translational medicine

authors： Milman Krentsis I,Rosen C,Shezen E,Aronovich A,Nathanson B,Bachar-Lustig E,Berkman N,Assayag M,Shakhar G,Feferman T,Orgad R,Reisner Y

更新日期：2018-01-01 00:00:00

abstract：:Unfortunately, many patients referred for hematopoietic cell transplant will not have a fully matched related donor, and finding matched unrelated donors through the registry may be difficult, especially if the recipient is not of Northern European descent [N Engl J Med 2014;371:339-348]. Umbilical cord blood (UCB) ha...

journal_title：Stem cells translational medicine

authors： Kindwall-Keller TL,Ballen KK

更新日期：2020-10-01 00:00:00

abstract：:Basic and translational research on lung biology has discovered multiple progenitor cell types, specialized or facultative, responsible for turnover, renewal, and repair. Isolation of populations of resident lung progenitor cells (LPCs) has been described by multiple protocols, and some have been successfully applied ...

journal_title：Stem cells translational medicine

authors： Chimenti I,Pagano F,Angelini F,Siciliano C,Mangino G,Picchio V,De Falco E,Peruzzi M,Carnevale R,Ibrahim M,Biondi-Zoccai G,Messina E,Frati G

更新日期：2017-03-01 00:00:00

abstract：:Vascular changes, including blood brain barrier destabilization, are common pathological features in multiple sclerosis (MS) lesions. Blood vessels within adult organs are reported to harbor mesenchymal stromal cells (MSCs) with phenotypical and functional characteristics similar to pericytes. We performed an immunohi...

journal_title：Stem cells translational medicine

authors： Iacobaeus E,Sugars RV,Törnqvist Andrén A,Alm JJ,Qian H,Frantzen J,Newcombe J,Alkass K,Druid H,Bottai M,Röyttä M,Le Blanc K

更新日期：2017-10-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can be isolated from bone marrow or other adult tissues (adipose tissue, dental pulp, amniotic fluid, and umbilical cord). In vitro, MSCs grow as adherent cells, display fibroblast-like morphology, and self-renew, undergoing specific mesodermal differentiation. High heterogeneity of MSCs ...

journal_title：Stem cells translational medicine

authors： Bajetto A,Thellung S,Dellacasagrande I,Pagano A,Barbieri F,Florio T

更新日期：2020-11-01 00:00:00

abstract：:γδT cells constitute a small proportion of lymphocytes in peripheral blood. Unlike αβT cells, the anti-tumor activities are exerted through several different pathways in a MHC-unrestricted manner. Thus, immunotherapy using γδT cells is considered to be effective for various types of cancer. Occasionally, however, ex v...

journal_title：Stem cells translational medicine

authors： Watanabe D,Koyanagi-Aoi M,Taniguchi-Ikeda M,Yoshida Y,Azuma T,Aoi T

更新日期：2018-01-01 00:00:00