Concise review: pluripotent stem cell-based regenerative applications for failing β-cell function.

abstract：:Bone marrow mesenchymal stem cells (BMSCs) have been shown to offer a wide variety of cellular functions including the protective effects on damaged hearts. Here we investigated the antiaging properties of BMSCs and the underlying mechanism in a cellular model of cardiomyocyte senescence and a rat model of aging heart...

journal_title：Stem cells translational medicine

authors： Zhang M,Liu D,Li S,Chang L,Zhang Y,Liu R,Sun F,Duan W,Du W,Wu Y,Zhao T,Xu C,Lu Y

更新日期：2015-05-01 00:00:00

abstract：:Functional hepatocytes, cardiomyocytes, neurons, and retinal pigment epithelial (RPE) cells derived from human embryonic stem cells (hESCs) or human induced pluripotent stem cells (hiPSCs) could provide a defined and renewable source of human cells relevant for cell replacement therapies, drug discovery, toxicology te...

journal_title：Stem cells translational medicine

authors： Toivonen S,Ojala M,Hyysalo A,Ilmarinen T,Rajala K,Pekkanen-Mattila M,Äänismaa R,Lundin K,Palgi J,Weltner J,Trokovic R,Silvennoinen O,Skottman H,Narkilahti S,Aalto-Setälä K,Otonkoski T

更新日期：2013-02-01 00:00:00

abstract：:Esophageal anastomotic leakage (EAL) is a devastating complication for esophagectomy but the available therapies are unsatisfactory. Due to the healing effects of mesenchymal stromal cells (MSCs) and supporting capability of fibrin scaffold (FS), we evaluated the efficacy of a stem-cell therapy for EAL by engrafting a...

journal_title：Stem cells translational medicine

authors： Xue X,Yan Y,Ma Y,Yuan Y,Li C,Lang X,Xu Z,Chen H,Zhang H

更新日期：2019-06-01 00:00:00

abstract：:Biomimetic scaffolds are extremely versatile in terms of chemical composition and physical properties, which can be defined to accomplish specific applications. One property that can be added is the production/release of bioactive soluble factors, either directly from the biomaterial, or from cells embedded within the...

journal_title：Stem cells translational medicine

authors： Menale C,Campodoni E,Palagano E,Mantero S,Erreni M,Inforzato A,Fontana E,Schena F,Van't Hof R,Sandri M,Tampieri A,Villa A,Sobacchi C

更新日期：2019-01-01 00:00:00

abstract：:Muscle-derived stem cells (MDSCs) isolated from mouse skeletal muscle by a modified preplate technique exhibit long-term proliferation, high self-renewal, and multipotent differentiation capabilities in vitro. MDSCs retrovirally transduced to express bone morphogenetic proteins (BMPs) can differentiate into osteocytes...

journal_title：Stem cells translational medicine

authors： Li H,Johnson NR,Usas A,Lu A,Poddar M,Wang Y,Huard J

更新日期：2013-09-01 00:00:00

abstract：:Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of cell therapy are mediated by both direct and indirect mechanisms. However, the application of stem cell therapy in the clinic is hampered by several limitations. This concise review provides a brief introduction into stem ce...

journal_title：Stem cells translational medicine

authors： Tang JN,Cores J,Huang K,Cui XL,Luo L,Zhang JY,Li TS,Qian L,Cheng K

更新日期：2018-04-01 00:00:00

abstract：:Vascular changes, including blood brain barrier destabilization, are common pathological features in multiple sclerosis (MS) lesions. Blood vessels within adult organs are reported to harbor mesenchymal stromal cells (MSCs) with phenotypical and functional characteristics similar to pericytes. We performed an immunohi...

journal_title：Stem cells translational medicine

authors： Iacobaeus E,Sugars RV,Törnqvist Andrén A,Alm JJ,Qian H,Frantzen J,Newcombe J,Alkass K,Druid H,Bottai M,Röyttä M,Le Blanc K

更新日期：2017-10-01 00:00:00

abstract：:The specific cell surface markers on mesenchymal stem/progenitor cells (MSCs) have been poorly defined in vivo, but in one recent study, an MSC subpopulation was directly isolated from a CD271-positive fraction of human bone marrow cells. The aim of this study was to identify circulating CD271(+) MSCs in human periphe...

journal_title：Stem cells translational medicine

authors： Iso Y,Yamaya S,Sato T,Poole CN,Isoyama K,Mimura M,Koba S,Kobayashi Y,Takeyama Y,Spees JL,Suzuki H

更新日期：2012-06-01 00:00:00

abstract：:Limbal stem cell (LSC) deficiency is a visually debilitating condition caused by abnormal maintenance of LSCs. It is treated by transplantation of donor-derived limbal epithelial cells (LECs), the success of which depends on the presence and quality of LSCs within the transplant. Understanding the immunobiological res...

journal_title：Stem cells translational medicine

authors： Shaharuddin B,Ahmad S,Md Latar N,Ali S,Meeson A

更新日期：2017-03-01 00:00:00

abstract：:Basic and translational research on lung biology has discovered multiple progenitor cell types, specialized or facultative, responsible for turnover, renewal, and repair. Isolation of populations of resident lung progenitor cells (LPCs) has been described by multiple protocols, and some have been successfully applied ...

journal_title：Stem cells translational medicine

authors： Chimenti I,Pagano F,Angelini F,Siciliano C,Mangino G,Picchio V,De Falco E,Peruzzi M,Carnevale R,Ibrahim M,Biondi-Zoccai G,Messina E,Frati G

更新日期：2017-03-01 00:00:00

abstract：:For years, our ability to study pathological changes in neurological diseases has been hampered by the lack of relevant models until the recent groundbreaking work from Yamanaka's group showing that it is feasible to generate induced pluripotent stem cells (iPSCs) from human somatic cells and to redirect the fate of t...

journal_title：Stem cells translational medicine

authors： Badja C,Maleeva G,El-Yazidi C,Barruet E,Lasserre M,Tropel P,Binetruy B,Bregestovski P,Magdinier F

更新日期：2014-12-01 00:00:00

abstract：:We conducted a phase II, noncomparative, multicenter study to assess the efficacy and safety of allogeneic bone marrow-derived mesenchymal stromal cells (BM-MSCs) expanded in vitro for patients with aplastic anemia (AA) refractory to immunosuppressive therapy. Seventy-four patients from seven centers received allogene...

journal_title：Stem cells translational medicine

authors： Pang Y,Xiao HW,Zhang H,Liu ZH,Li L,Gao Y,Li HB,Jiang ZJ,Tan H,Lin JR,Du X,Weng JY,Nie DN,Lin DJ,Zhang XZ,Liu QF,Xu DR,Chen HJ,Ge XH,Wang XY,Xiao Y

更新日期：2017-07-01 00:00:00

abstract：:Studies of human cerebral cortex development are limited by difficulties in accessing and manipulating human neural tissue at specific development stages. We have derived human radial glia (hRG), which are responsible for most cerebral cortex neurogenesis, from human pluripotent stem cells. These hRG display the hallm...

journal_title：Stem cells translational medicine

authors： Duan L,Peng CY,Pan L,Kessler JA

更新日期：2015-05-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) play key roles in the production of mature blood cells and in the biology and clinical outcomes of hematopoietic transplants. The numbers of these cells, however, are extremely low, particularly in umbilical cord blood (UCB); thus, ex vivo expan...

journal_title：Stem cells translational medicine

authors： Flores-Guzmán P,Fernández-Sánchez V,Mayani H

更新日期：2013-11-01 00:00:00

abstract：:Mesenchymal stem cells (multipotent stromal cells; MSCs) have been under investigation for the treatment of diverse diseases, with many promising outcomes achieved in animal models and clinical trials. The biological activity of MSC therapies has not been fully resolved which is critical to rationalizing their use and...

journal_title：Stem cells translational medicine

authors： Stavely R,Nurgali K

更新日期：2020-09-01 00:00:00

abstract：:Organoids are three-dimensional culture systems in which adult stem cells and their progeny grow and represent the native physiology of the cells in vivo. Organoids have been successfully derived from several organ systems in both animal models and human patients. Organoids have been used for fundamental research, dis...

journal_title：Stem cells translational medicine

authors： Nantasanti S,de Bruin A,Rothuizen J,Penning LC,Schotanus BA

更新日期：2016-03-01 00:00:00

abstract：:The potential plasticity and therapeutic utility in tissue regeneration of human adipose-derived stem cells (ASCs) isolated from adult adipose tissue have recently been highlighted. The use of autologous platelet-rich plasma (PRP) represents an alternative strategy in regenerative medicine for the local release of mul...

journal_title：Stem cells translational medicine

authors： Cervelli V,Scioli MG,Gentile P,Doldo E,Bonanno E,Spagnoli LG,Orlandi A

更新日期：2012-03-01 00:00:00

abstract：:Cardiovascular disease is a major cause of morbidity and mortality, especially in developed countries. Various therapies for cardiovascular disease are investigated actively and are performed clinically. Recently, cell-based regenerative medicine using several cell sources has appeared as an alternative therapy for cu...

journal_title：Stem cells translational medicine

authors： Haraguchi Y,Shimizu T,Yamato M,Okano T

更新日期：2012-02-01 00:00:00

abstract：:Emerging data suggest that cancer stem cells (CSCs) exist in equilibrium with differentiated cells and that stochastic transitions between these states can account for tumor heterogeneity and drug resistance. The aim of this study was to establish an in vitro system that recapitulates stem cell plasticity in head and ...

journal_title：Stem cells translational medicine

authors： Leong HS,Chong FT,Sew PH,Lau DP,Wong BH,Teh BT,Tan DS,Iyer NG

更新日期：2014-09-01 00:00:00

abstract：UNLABELLED:Cell secretion is an important mechanism for stem cell-based therapeutic angiogenesis, along with cell differentiation to vascular endothelial cells or smooth muscle cells. Cell-released microvesicles (MVs) have been recently implicated to play an essential role in intercellular communication. The purpose of...

journal_title：Stem cells translational medicine

authors： Kang T,Jones TM,Naddell C,Bacanamwo M,Calvert JW,Thompson WE,Bond VC,Chen YE,Liu D

更新日期：2016-04-01 00:00:00

abstract：:Multipotent mesenchymal stromal cell (MSC) therapy and costimulation blockade are two immunomodulatory strategies being developed concomitantly for the treatment of immunological diseases. Both of these strategies have the capacity to inhibit immune responses and induce regulatory T cells; however, their ability to sy...

journal_title：Stem cells translational medicine

authors： Takahashi T,Tibell A,Ljung K,Saito Y,Gronlund A,Osterholm C,Holgersson J,Lundgren T,Ericzon BG,Corbascio M,Kumagai-Braesch M

更新日期：2014-12-01 00:00:00

abstract：:Osteoarthritis (OA) remains an intractable clinical challenge. Few drugs are available for reversing this degenerative disease, although some promising candidates have performed well in preclinical studies. Tumor necrosis factor α (TNFα) has been identified as a crucial effector modulating OA pathogenesis. This study ...

journal_title：Stem cells translational medicine

authors： Xia Q,Zhu S,Wu Y,Wang J,Cai Y,Chen P,Li J,Heng BC,Ouyang HW,Lu P

更新日期：2015-05-01 00:00:00

abstract：UNLABELLED:Histone deacetylase (HDAC) inhibitors possess therapeutic potential to reverse aberrant epigenetic changes associated with cancers, neurological diseases, and immune disorders. Unfortunately, clinical studies with some HDAC inhibitors displayed delayed cardiac adverse effects, such as atrial fibrillation and...

journal_title：Stem cells translational medicine

authors： Kopljar I,Gallacher DJ,De Bondt A,Cougnaud L,Vlaminckx E,Van den Wyngaert I,Lu HR

更新日期：2016-05-01 00:00:00

abstract：UNLABELLED:: Chronic rotator cuff (RC) tears are a common and debilitating injury, characterized by dramatic expansion of adipose tissue, muscle atrophy, and limited functional recovery. The role of adipose expansion in RC pathology is unknown; however, given the identified paracrine/endocrine regulation by other adipo...

journal_title：Stem cells translational medicine

authors： Meyer GA,Gibbons MC,Sato E,Lane JG,Ward SR,Engler AJ

更新日期：2015-07-01 00:00:00

abstract：:Lamin A (LMNA)-linked lipodystrophies may be either genetic (associated with LMNA mutations) or acquired (associated with the use of human immunodeficiency virus protease inhibitors [PIs]), and in both cases they share clinical features such as anomalous distribution of body fat or generalized loss of adipose tissue, ...

journal_title：Stem cells translational medicine

authors： Ruiz de Eguino G,Infante A,Schlangen K,Aransay AM,Fullaondo A,Soriano M,García-Verdugo JM,Martín AG,Rodríguez CI

更新日期：2012-04-01 00:00:00

abstract：:Improved therapeutic assessment of experimental traumatic brain injury (TBI), using mesenchymal stem cells (MSCs), would immensely benefit its therapeutic management. Neurometabolite patterns at injury site, measured with proton magnetic resonance spectroscopy (1H-MRS) after MSCs transplantation, may serve as a bio-in...

journal_title：Stem cells translational medicine

authors： Mishra SK,Rana P,Khushu S,Gangenahalli G

更新日期：2017-01-01 00:00:00

abstract：UNLABELLED:Rotator cuff tendon tear is one of the most common causes of chronic shoulder pain and disability. In this study, we investigated the therapeutic effects of ultrasound-guided human umbilical cord blood (UCB)-derived mesenchymal stem cell (MSC) injection to regenerate a full-thickness subscapularis tendon tea...

journal_title：Stem cells translational medicine

authors： Park GY,Kwon DR,Lee SC

更新日期：2015-11-01 00:00:00

abstract：:Animal models show that systemically administered bone marrow-derived mesenchymal stem cells (MSCs) home to sites of primary and metastatic prostate cancer (PC)-making them candidates to selectively deliver cytotoxic agents. To further assess this potential as a cell-based therapeutic vehicle, a phase I study testing ...

journal_title：Stem cells translational medicine

authors： Schweizer MT,Wang H,Bivalacqua TJ,Partin AW,Lim SJ,Chapman C,Abdallah R,Levy O,Bhowmick NA,Karp JM,De Marzo A,Isaacs JT,Brennen WN,Denmeade SR

更新日期：2019-05-01 00:00:00

abstract：:Recent reports have indicated human embryonic stem cells-derived midbrain dopamine (mDA) neurons as proper cell resources for use in Parkinson's disease (PD) therapy. Nevertheless, no detailed and systematic study has been conducted to identify which differentiation stages of mDA cells are most suitable for transplant...

journal_title：Stem cells translational medicine

authors： Qiu L,Liao MC,Chen AK,Wei S,Xie S,Reuveny S,Zhou ZD,Hunziker W,Tan EK,Oh SKW,Zeng L

更新日期：2017-09-01 00:00:00

abstract：:Peripheral nerve injury presents significant therapeutic challenges for recovery of motor and sensory function in patients. Different clinical approaches exist but to date there has been no consensus on the most effective method of treatment. Here, we investigate a novel approach to peripheral nerve repair using olfac...

journal_title：Stem cells translational medicine

authors： Roche P,Alekseeva T,Widaa A,Ryan A,Matsiko A,Walsh M,Duffy GP,O'Brien FJ

更新日期：2017-10-01 00:00:00