Platelet-Derived Mitochondria Display Embryonic Stem Cell Markers and Improve Pancreatic Islet β-cell Function in Humans.

abstract：:Xenogeneic-free media are required for translating advanced therapeutic medicinal products to the clinics. In addition, process efficiency is crucial for ensuring cost efficiency, especially when considering large-scale production of mesenchymal stem cells (MSCs). Human platelet lysate (HPL) has been increasingly adop...

journal_title：Stem cells translational medicine

authors： Gupta P,Hall GN,Geris L,Luyten FP,Papantoniou I

更新日期：2019-08-01 00:00:00

abstract：:Emerging data suggest that cancer stem cells (CSCs) exist in equilibrium with differentiated cells and that stochastic transitions between these states can account for tumor heterogeneity and drug resistance. The aim of this study was to establish an in vitro system that recapitulates stem cell plasticity in head and ...

journal_title：Stem cells translational medicine

authors： Leong HS,Chong FT,Sew PH,Lau DP,Wong BH,Teh BT,Tan DS,Iyer NG

更新日期：2014-09-01 00:00:00

abstract：:The present first-in-human clinical trial evaluated the safety and feasibility of a newly developed and cryopreserved Cardiology Stem Cell Centre adipose-derived stromal cell (CSCC_ASC) product from healthy donors for intramyocardial injection in ten patients with ischemic heart disease and ischemic heart failure (IHF...

journal_title：Stem cells translational medicine

authors： Kastrup J,Haack-Sørensen M,Juhl M,Harary Søndergaard R,Follin B,Drozd Lund L,Mønsted Johansen E,Ali Qayyum A,Bruun Mathiasen A,Jørgensen E,Helqvist S,Jørgen Elberg J,Bruunsgaard H,Ekblond A

更新日期：2017-11-01 00:00:00

abstract：:Animal models show that systemically administered bone marrow-derived mesenchymal stem cells (MSCs) home to sites of primary and metastatic prostate cancer (PC)-making them candidates to selectively deliver cytotoxic agents. To further assess this potential as a cell-based therapeutic vehicle, a phase I study testing ...

journal_title：Stem cells translational medicine

authors： Schweizer MT,Wang H,Bivalacqua TJ,Partin AW,Lim SJ,Chapman C,Abdallah R,Levy O,Bhowmick NA,Karp JM,De Marzo A,Isaacs JT,Brennen WN,Denmeade SR

更新日期：2019-05-01 00:00:00

abstract：:Patients with laryngeal disorders may have severe morbidity relating to swallowing, vocalization, and respiratory function, for which conventional therapies are suboptimal. A tissue-engineered approach would aim to restore the vocal folds and maintain respiratory function while limiting the extent of scarring in the r...

journal_title：Stem cells translational medicine

authors： Ansari T,Lange P,Southgate A,Greco K,Carvalho C,Partington L,Bullock A,MacNeil S,Lowdell MW,Sibbons PD,Birchall MA

更新日期：2017-02-01 00:00:00

abstract：:: Paracrine signaling by bone-marrow-derived mesenchymal stem cells (MSCs) plays a major role in tissue repair. Although the production of regulatory cytokines by MSC transplantation is a critical modulator of tissue regeneration, we focused on exosomes, which are extracellular vesicles that contain proteins and nucle...

journal_title：Stem cells translational medicine

authors： Furuta T,Miyaki S,Ishitobi H,Ogura T,Kato Y,Kamei N,Miyado K,Higashi Y,Ochi M

更新日期：2016-12-01 00:00:00

abstract：:Functional hepatocytes, cardiomyocytes, neurons, and retinal pigment epithelial (RPE) cells derived from human embryonic stem cells (hESCs) or human induced pluripotent stem cells (hiPSCs) could provide a defined and renewable source of human cells relevant for cell replacement therapies, drug discovery, toxicology te...

journal_title：Stem cells translational medicine

authors： Toivonen S,Ojala M,Hyysalo A,Ilmarinen T,Rajala K,Pekkanen-Mattila M,Äänismaa R,Lundin K,Palgi J,Weltner J,Trokovic R,Silvennoinen O,Skottman H,Narkilahti S,Aalto-Setälä K,Otonkoski T

更新日期：2013-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are very attractive candidates in cell-based strategies that target inflammatory diseases. Preclinical animal studies and many clinical trials have demonstrated that human MSCs can be safely administered and that they modify the inflammatory process in the targeted injured tissue. Our lab...

journal_title：Stem cells translational medicine

authors： Waterman RS,Morgenweck J,Nossaman BD,Scandurro AE,Scandurro SA,Betancourt AM

更新日期：2012-07-01 00:00:00

abstract：UNLABELLED:Human placental mesenchymal stromal cells (pMSCs) have never been investigated in intrauterine growth restriction (IUGR). We characterized cells isolated from placental membranes and the basal disc of six IUGR and five physiological placentas. Cell viability and proliferation were assessed every 7 days durin...

journal_title：Stem cells translational medicine

authors： Mandò C,Razini P,Novielli C,Anelli GM,Belicchi M,Erratico S,Banfi S,Meregalli M,Tavelli A,Baccarin M,Rolfo A,Motta S,Torrente Y,Cetin I

更新日期：2016-04-01 00:00:00

abstract：:Tissue regeneration using progenitor cell-based therapy has the potential to aid in the healing of a diverse range of pathologies, ranging from short-gut syndrome to spinal cord lesions. However, there are numerous hurdles to be overcome prior to the widespread application of these cells in the clinical setting. One o...

journal_title：Stem cells translational medicine

authors： Hyun J,Grova M,Nejadnik H,Lo D,Morrison S,Montoro D,Chung M,Zimmermann A,Walmsley GG,Lee M,Daldrup-Link H,Wan DC,Longaker MT

更新日期：2013-09-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) in COVID-19 is associated with high mortality. Mesenchymal stem cells are known to exert immunomodulatory and anti-inflammatory effects and could yield beneficial effects in COVID-19 ARDS. The objective of this study was to determine safety and explore efficacy of umbilical c...

journal_title：Stem cells translational medicine

authors： Lanzoni G,Linetsky E,Correa D,Messinger Cayetano S,Alvarez RA,Kouroupis D,Alvarez Gil A,Poggioli R,Ruiz P,Marttos AC,Hirani K,Bell CA,Kusack H,Rafkin L,Baidal D,Pastewski A,Gawri K,Leñero C,Mantero AMA,Metalonis SW

更新日期：2021-01-05 00:00:00

abstract：:Human-induced pluripotent stem cells (hiPSCs)-based cell therapy holds promise for treating stress urinary incontinence (SUI). However, safety concerns, especially tumorgenic potential of residual undifferentiated cells in hiPSC derivatives, are major barriers for its clinical translation. An efficient, fast and clini...

journal_title：Stem cells translational medicine

authors： Li Y,Green M,Wen Y,Wei Y,Wani P,Wang Z,Reijo Pera R,Chen B

更新日期：2017-04-01 00:00:00

abstract：:The differentiation of human stem cells into insulin secreting beta-like cells holds great promise to treat diabetes. Current protocols drive stem cells through stages of directed differentiation and maturation and produce cells that secrete insulin in response to glucose. Further refinements are now needed to faithfu...

journal_title：Stem cells translational medicine

authors： Singh R,Cottle L,Loudovaris T,Xiao D,Yang P,Thomas HE,Kebede MA,Thorn P

更新日期：2020-11-04 00:00:00

abstract：:Adipose tissue-derived multipotent stromal cells (AT-MSCs) are studied as an alternative to bone marrow-derived multipotent stromal cells (BM-MSCs) for immunomodulatory treatment. In this study, we systematically compared the immunomodulatory capacities of BM-MSCs and AT-MSCs derived from age-matched donors. We found ...

journal_title：Stem cells translational medicine

authors： Melief SM,Zwaginga JJ,Fibbe WE,Roelofs H

更新日期：2013-06-01 00:00:00

abstract：:Osteoarthritic and other types of articular cartilage defects never heal on their own. Medicinal and surgical approaches are often ineffective, and the supply of autologous chondrocytes for tissue engineering is very limited. Bone marrow stromal cells (BMSCs, also known as bone marrow-derived mesenchymal stem cells) h...

journal_title：Stem cells translational medicine

authors： Kuznetsov SA,Hailu-Lazmi A,Cherman N,de Castro LF,Robey PG,Gorodetsky R

更新日期：2019-06-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been investigated as a clinical therapy to promote tissue repair. However, the disappearance of grafted cells soon after engraftment suggests a possible role as initiators of repair rather than effectors. We evaluated the relative contribution of grafted human MSCs and host stem/prog...

journal_title：Stem cells translational medicine

authors： Shin L,Peterson DA

更新日期：2013-01-01 00:00:00

abstract：:Heart diseases (HDs) are the leading cause of morbidity and mortality worldwide. Despite remarkable clinical progress made, current therapies cannot restore the lost myocardium, and the correlation of genotype to phenotype of many HDs is poorly modeled. In the past two decades, with the rapid developments of human plu...

journal_title：Stem cells translational medicine

authors： Li Q,Wang J,Wu Q,Cao N,Yang HT

更新日期：2020-10-01 00:00:00

abstract：:Unfortunately, many patients referred for hematopoietic cell transplant will not have a fully matched related donor, and finding matched unrelated donors through the registry may be difficult, especially if the recipient is not of Northern European descent [N Engl J Med 2014;371:339-348]. Umbilical cord blood (UCB) ha...

journal_title：Stem cells translational medicine

authors： Kindwall-Keller TL,Ballen KK

更新日期：2020-10-01 00:00:00

abstract：:Infection with the SARS-CoV-2 virus has rapidly become a global pandemic for which we were not prepared. Several clinical trials using previously approved drugs and drug combinations are urgently under way to improve the current situation. A vaccine option has only recently become available, but worldwide distribution...

journal_title：Stem cells translational medicine

authors： Esmail S,Danter W

更新日期：2021-02-01 00:00:00

abstract：:Techniques that enable longitudinal tracking of cell fate after myocardial delivery are imperative for optimizing the efficacy of cell-based cardiac therapies. However, these approaches have been underutilized in preclinical models and clinical trials, and there is considerable demand for site-specific strategies achi...

journal_title：Stem cells translational medicine

authors： Ostrominski JW,Yada RC,Sato N,Klein M,Blinova K,Patel D,Valadez R,Palisoc M,Pittaluga S,Peng KW,San H,Lin Y,Basuli F,Zhang X,Swenson RE,Haigney M,Choyke PL,Zou J,Boehm M,Hong SG,Dunbar CE

更新日期：2020-10-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (BMSCs) have been shown to offer a wide variety of cellular functions including the protective effects on damaged hearts. Here we investigated the antiaging properties of BMSCs and the underlying mechanism in a cellular model of cardiomyocyte senescence and a rat model of aging heart...

journal_title：Stem cells translational medicine

authors： Zhang M,Liu D,Li S,Chang L,Zhang Y,Liu R,Sun F,Duan W,Du W,Wu Y,Zhao T,Xu C,Lu Y

更新日期：2015-05-01 00:00:00

abstract：UNLABELLED:Studies in hypertension (HTN) pharmacogenomics seek to identify genetic sources of variable antihypertensive drug response. Genetic association studies have detected single-nucleotide polymorphisms (SNPs) that link to drug responses; however, to understand mechanisms underlying how genetic traits alter drug ...

journal_title：Stem cells translational medicine

authors： Biel NM,Santostefano KE,DiVita BB,El Rouby N,Carrasquilla SD,Simmons C,Nakanishi M,Cooper-DeHoff RM,Johnson JA,Terada N

更新日期：2015-12-01 00:00:00

abstract：:Breast cancer-related lymphedema (BCRL) is a debilitating late complication with a lack of treatment opportunities. Recent studies have suggested that mesenchymal stromal cells can alleviate lymphedema. Herein, we report the results from the first human pilot study with freshly isolated adipose-derived regenerative ce...

journal_title：Stem cells translational medicine

authors： Toyserkani NM,Jensen CH,Andersen DC,Sheikh SP,Sørensen JA

更新日期：2017-08-01 00:00:00

abstract：:The specific cell surface markers on mesenchymal stem/progenitor cells (MSCs) have been poorly defined in vivo, but in one recent study, an MSC subpopulation was directly isolated from a CD271-positive fraction of human bone marrow cells. The aim of this study was to identify circulating CD271(+) MSCs in human periphe...

journal_title：Stem cells translational medicine

authors： Iso Y,Yamaya S,Sato T,Poole CN,Isoyama K,Mimura M,Koba S,Kobayashi Y,Takeyama Y,Spees JL,Suzuki H

更新日期：2012-06-01 00:00:00

abstract：:The kidney is a specialized low-regenerative organ with several different types of cellular lineages; however, the identity of renal stem/progenitor cells with nephrogenic potential and their preferred niche(s) are largely unknown and debated. Most of the therapeutic approaches to kidney regeneration are based on admi...

journal_title：Stem cells translational medicine

authors： Aggarwal S,Moggio A,Bussolati B

更新日期：2013-12-01 00:00:00

abstract：UNLABELLED:Cell secretion is an important mechanism for stem cell-based therapeutic angiogenesis, along with cell differentiation to vascular endothelial cells or smooth muscle cells. Cell-released microvesicles (MVs) have been recently implicated to play an essential role in intercellular communication. The purpose of...

journal_title：Stem cells translational medicine

authors： Kang T,Jones TM,Naddell C,Bacanamwo M,Calvert JW,Thompson WE,Bond VC,Chen YE,Liu D

更新日期：2016-04-01 00:00:00

abstract：:Standardization guidelines for human pluripotent stem cells are still very broadly defined, despite ongoing clinical trials in the U.S., U.K., and Japan. The requirements for validation of human embryonic (hESCs) and induced pluripotent stem cells (iPSCs) in general follow the regulations for other clinically complian...

journal_title：Stem cells translational medicine

authors： Devito L,Petrova A,Miere C,Codognotto S,Blakely N,Lovatt A,Ogilvie C,Khalaf Y,Ilic D

更新日期：2014-10-01 00:00:00

abstract：:Adipose-derived stem cell (ADSC)-based therapy is promising for critical limb ischemia (CLI) treatment, especially in patients with diabetes. However, the therapeutic effects of diabetic ADSCs (D-ADSCs) are impaired by the diabetes, possibly through intracellular reactive oxygen species (ROS) accumulation. The objecti...

journal_title：Stem cells translational medicine

authors： Peng Z,Yang X,Qin J,Ye K,Wang X,Shi H,Jiang M,Liu X,Lu X

更新日期：2017-01-01 00:00:00

abstract：:Multipotent mesenchymal stromal cell (MSC) therapy and costimulation blockade are two immunomodulatory strategies being developed concomitantly for the treatment of immunological diseases. Both of these strategies have the capacity to inhibit immune responses and induce regulatory T cells; however, their ability to sy...

journal_title：Stem cells translational medicine

authors： Takahashi T,Tibell A,Ljung K,Saito Y,Gronlund A,Osterholm C,Holgersson J,Lundgren T,Ericzon BG,Corbascio M,Kumagai-Braesch M

更新日期：2014-12-01 00:00:00

abstract：:Cancer stem cells play a critical role in disease initiation and insensitivity to chemotherapy in numerous hematologic malignancies and some solid tumors, and these stem cells need to be eradicated to achieve a cure. Key to successful targeting of cancer stem cells is to identify and functionally test critical target ...

journal_title：Stem cells translational medicine

authors： Zhang H,Li S

更新日期：2019-08-01 00:00:00