Abstract：
:Controlling the residual glucose concentration is important for improving productivity in L-threonine fermentation. In this study, we developed a procedure to automatically control the feeding quantity of glucose solution as a function of ammonia-water consumption rate. The feeding ratio (RC/N) of glucose and ammonia water was predetermined via a stoichiometric approach, on the basis of glucose-ammonia water consumption rates. In a 5-L fermenter, 102 g/l L-threonine was obtained using our glucose-ammonia water combined feeding strategy, which was then successfully applied in a 500-L fermenter (89 g/l). Therefore, we conclude that an automatic combination feeding strategy is suitable for improving L-threonine production.
journal_name
J Microbiol Biotechnoljournal_title
Journal of microbiology and biotechnologyauthors
Lee HW,Lee HS,Kim CS,Lee JG,Kim WK,Lee EG,Lee HWdoi
10.4014/jmb.1708.08072subject
Has Abstractpub_date
2018-02-28 00:00:00pages
293-297issue
2eissn
1017-7825issn
1738-8872pii
10.4014/jmb.1708.08072journal_volume
28pub_type
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