HCV core antigen is an alternative marker to HCV RNA for evaluating active HCV infection: implications for improved diagnostic option in an era of affordable DAAs.

abstract：Background:Over the last two decades, there has been a constant increase in prescription rates of antidepressants. In parallel, neuroactive pharmaceuticals are making their way into aquatic environments at increasing concentrations. Among the antidepressants detected in the environment citalopram, a selective serotonin...

journal_title：PeerJ

authors： Ziegler M,Knoll S,Köhler HR,Tisler S,Huhn C,Zwiener C,Triebskorn R

更新日期：2020-03-12 00:00:00

abstract：Introduction:Whole-metagenome sequencing can be a rich source of information about the structure and function of entire metagenomic communities, but getting accurate and reliable results from these datasets can be challenging. Analysis of these datasets is founded on the mapping of sequencing reads onto known genomic r...

journal_title：PeerJ

authors： Greenfield P,Tran-Dinh N,Midgley D

更新日期：2019-01-30 00:00:00

abstract：:Neem (Azadirachta indica A. Juss) is one of the most versatile tropical evergreen tree species known in India since the Vedic period (1500 BC-600 BC). Neem tree is a rich source of limonoids, having a wide spectrum of activity against insect pests and microbial pathogens. Complex tetranortriterpenoids such as azadirac...

journal_title：PeerJ

authors： Kuravadi NA,Yenagi V,Rangiah K,Mahesh HB,Rajamani A,Shirke MD,Russiachand H,Loganathan RM,Shankara Lingu C,Siddappa S,Ramamurthy A,Sathyanarayana BN,Gowda M

更新日期：2015-08-06 00:00:00

abstract：Background:G. boninense is a hemibiotrophic fungus that infects oil palms (Elaeis guineensis Jacq.) causing basal stem rot (BSR) disease and consequent massive economic losses to the oil palm industry. The pathogenicity of this white-rot fungus has been associated with cell wall degrading enzymes (CWDEs) released durin...

journal_title：PeerJ

authors： Ramzi AB,Che Me ML,Ruslan US,Baharum SN,Nor Muhammad NA

更新日期：2019-12-18 00:00:00

abstract：:In this work, we studied the main characteristics of flowering, reproductive system and diversity of pollinators for the biofuel plant Jatropha curcas (L.) in a site of tropical southeastern Mexico, within its center of origin. The plants were monoecious with inflorescences of unisexual flowers. The male flowers produ...

journal_title：PeerJ

authors： Rincón-Rabanales M,Vargas-López LI,Adriano-Anaya L,Vázquez-Ovando A,Salvador-Figueroa M,Ovando-Medina I

更新日期：2016-03-14 00:00:00

abstract：:Sponges are efficient filter feeders, removing significant portions of particulate and dissolved organic matter (POM, DOM) from the water column. While the assimilation and respiration of POM and DOM by sponges and their abundant microbial symbiont communities have received much attention, there is virtually no inform...

journal_title：PeerJ

authors： Fiore CL,Freeman CJ,Kujawinski EB

更新日期：2017-01-11 00:00:00

abstract：:Meniscal tears are a common cause of stifle lameness in dogs. Use of autologous synoviocytes from the affected stifle is an attractive cell source for tissue engineering replacement fibrocartilage. However, the diseased state of these cells may impede in vitro fibrocartilage formation. Synoviocytes from 12 osteoarthri...

journal_title：PeerJ

authors： Warnock JJ,Bobe G,Duesterdieck-Zellmer KF

更新日期：2014-09-30 00:00:00

abstract：:Freshwater food webs are dominated by aquatic invertebrates whose trophic relationships are often poorly known. Here, I used laboratory experiments to study the role of a water bug, Sigara striata, as a potential predator and prey in food webs of stagnant waters. Multiple-choice predation experiment revealed that Siga...

journal_title：PeerJ

authors： Klecka J

更新日期：2014-05-22 00:00:00

abstract：:Prostaglandin E1 (PGE1), known pharmaceutically as alprostadil, has vasodilatory properties and is used widely in various clinical settings. In addition to acute vasodilatory properties, PGE1 may exert beneficial effects by altering protein expression of vascular cells. PGE1 is reported to be a potent stimulator of an...

journal_title：PeerJ

authors： Suzuki K,Nishi K,Takabuchi S,Kai S,Matsuyama T,Kurosawa S,Adachi T,Maruyama T,Fukuda K,Hirota K

更新日期：2013-11-28 00:00:00

abstract：:Background.Chinese fir [Cunninghamia lanceolata (Lamb.) Hook.] is one of the most important native tree species for timber production in southern China. An understanding of overall fast growing stage, stem growth stage and senescence stage cambium transcriptome variation is lacking. We used transcriptome sequencing to...

journal_title：PeerJ

authors： Zhang Y,Han X,Sang J,He X,Liu M,Qiao G,Zhuo R,He G,Hu J

更新日期：2016-06-07 00:00:00

abstract：:Background. Most genetic disorders are caused by single nucleotide variations (SNVs) or small insertion/deletions (indels). High throughput sequencing has broadened the catalogue of human variation, including common polymorphisms, rare variations or disease causing mutations. However, identifying one variation among h...

journal_title：PeerJ

authors： Geoffroy V,Pizot C,Redin C,Piton A,Vasli N,Stoetzel C,Blavier A,Laporte J,Muller J

更新日期：2015-03-03 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) pathway shows frequent aberrant alterations and pathological activation in breast cancer cells. While PI3K inhibitors have not achieved expectant therapeutic efficacy in clinical trials, and several studies provide promising combination strategies to substantially maximize therapeu...

journal_title：PeerJ

authors： Qin H,Liu L,Sun S,Zhang D,Sheng J,Li B,Yang W

更新日期：2018-06-19 00:00:00

abstract：:Prior work in our lab has shown that an expanding image on a computer screen elicits a hiding response in the Caribbean terrestrial hermit crab (Coenobita clypeatus). We conducted two experiments to identify what properties of the expanding stimulus contribute to its effectiveness as a visual threat. First we found th...

journal_title：PeerJ

authors： Shragai T,Ping X,Arakaki C,Garlick D,Blumstein DT,Blaisdell AP

更新日期：2017-11-30 00:00:00

abstract：Background:Acute respiratory distress syndrome (ARDS) is associated with significantly increased risk of death, and early risk stratification may help to choose the appropriate treatment. The study aimed to develop a neural network model by using a genetic algorithm (GA) for the prediction of mortality in patients with...

journal_title：PeerJ

authors： Zhang Z

更新日期：2019-09-16 00:00:00

abstract：:Studies on the adverse health effects caused by azo dyes are insufficient and quite contradictory. This work aims to investigate the possible toxic effect of two types of widely used food additives, Sunset Yellow and Allura Red, by assessing the physiological, histopathological and ultrastructural changes in the liver...

journal_title：PeerJ

authors： Khayyat LI,Essawy AE,Sorour JM,Soffar A

更新日期：2018-09-28 00:00:00

abstract：:The genus Nothofagus is the main component of southern South American temperate forests. The 40 Nothofagus species, evergreen and deciduous, and some natural hybrids are spread among Central and Southern Chile, Argentina, New Zealand, Australia, New Guinea and New Caledonia. Nothofagus nervosa, Nothofagus obliqua and ...

journal_title：PeerJ

authors： Solano J,Anabalón L,Encina F,Esse C,Penneckamp D

更新日期：2019-05-09 00:00:00

abstract：:The MYB transcription factor family is one of the largest gene families playing regulatory roles in plant growth and development. The MYB family has been studied in a variety of plant species but has not been reported in Taxus chinensis. Here we identified 72 putative R2R3-MYB genes in T. chinensis using a comprehensi...

journal_title：PeerJ

authors： Hu X,Zhang L,Wilson I,Shao F,Qiu D

更新日期：2020-02-17 00:00:00

abstract：:At the turn of February and March 2020, COVID-19 pandemic reached Europe. Many countries, including Poland imposed lockdown as a method of securing social distance between potentially infected. Stay-at-home orders and movement control within public space not only affected the touristm industry, but also the everyday l...

journal_title：PeerJ

authors： Szczepanek R

更新日期：2020-10-05 00:00:00

abstract：BACKGROUND:Antimicrobial peptides (AMPs) are of great potential as novel antibiotics for the treatment of broad spectrum of pathogenic microorganisms including resistant bacteria. In this study, the mechanisms of action and the therapeutic efficacy of the hybrid peptides were examined. METHODS:TEM, SEM and ATP efflux ...

journal_title：PeerJ

authors： Jindal HM,Zandi K,Ong KC,Velayuthan RD,Rasid SM,Samudi Raju C,Sekaran SD

更新日期：2017-10-05 00:00:00

abstract：:In functional genomics experiments, researchers often select genes to follow-up or validate from a long list of differentially expressed genes. Typically, sharp thresholds are used to bin genes into groups such as significant/non-significant or fold change above/below a cut-off value, and ad hoc criteria are also used...

journal_title：PeerJ

authors： Lazic SE

更新日期：2015-11-26 00:00:00

abstract：:Populations undergoing rapid climate-driven range expansion experience distinct selection regimes dominated both by increased dispersal at the leading edges and steep environmental gradients. Characterisation of traits associated with such expansions provides insight into the selection pressures and evolutionary const...

journal_title：PeerJ

authors： Taylor-Cox ED,Macgregor CJ,Corthine A,Hill JK,Hodgson JA,Saccheri IJ

更新日期：2020-11-19 00:00:00

abstract：:Mega-journals are a new kind of scholarly journal made possible by electronic publishing. They are open access (OA) and funded by charges, which authors pay for the publishing services. What distinguishes mega-journals from other OA journals is, in particular, a peer review focusing only on scientific trustworthiness....

journal_title：PeerJ

authors： Björk BC

更新日期：2018-02-09 00:00:00

abstract：Background:Bioactive peptides can prevent damage associated with oxidative stress in humans when consumed regularly. Recently, peptides have attracted immense interest because of their beneficial functional properties, safety and little or no side effects when used at high concentration. Most antioxidant peptides are s...

journal_title：PeerJ

authors： Sonklin C,Laohakunjit N,Kerdchoechuen O

更新日期：2018-07-27 00:00:00

abstract：Background:High throughput DNA sequencing of bulk invertebrate samples or metabarcoding is becoming increasingly used to provide profiles of biological communities for environmental monitoring. As metabarcoding becomes more widely applied, new reference DNA barcodes linked to individual specimens identified by taxonomi...

journal_title：PeerJ

authors： Carew ME,Coleman RA,Hoffmann AA

更新日期：2018-06-13 00:00:00

abstract：:The reliability of finite element analysis (FEA) in biomechanical investigations depends upon understanding the influence of model assumptions. In producing finite element models, surface mesh resolution is influenced by the resolution of input geometry, and influences the resolution of the ensuing solid mesh used for...

journal_title：PeerJ

authors： McCurry MR,Evans AR,McHenry CR

更新日期：2015-06-02 00:00:00

abstract：BACKGROUND:Assessing psychological pain has been recommended as an integral part of a comprehensive suicide risk assessment. The Psychache Scale, an established measure of psychological pain, does not specify a time frame for when pain is experienced, which may inadvertently increase the likelihood of identifying indiv...

journal_title：PeerJ

authors： Meerwijk EL,Weiss SJ

更新日期：2017-06-22 00:00:00

abstract：:Bacterial vaginosis (BV) is one of most common vaginal infections. However, its diagnosis by classical methods reveals low specificity. Our goal was to evaluate the accuracy diagnosis of 150 vaginal samples with research gold standard methods and our Peptide Nucleic Acid (PNA) probes by Fluorescence in situ Hybridizat...

journal_title：PeerJ

authors： Machado A,Castro J,Cereija T,Almeida C,Cerca N

更新日期：2015-02-17 00:00:00

abstract：:Rhizoctonia solani causes the disease peanut sheath blight, involving symptoms of maceration and necrosis of infected tissue, mainly caused by cell-wall-degrading enzymes (CWDEs). This study investigated the production of CWDEs including polygalacturonase (PG), polymethyl-galacturonase (PMG), cellulase (Cx) and β-gluc...

journal_title：PeerJ

authors： Xue CY,Zhou RJ,Li YJ,Xiao D,Fu JF

更新日期：2018-09-05 00:00:00

abstract：:The systematic relationships of taxa traditionally referred to as 'basal ornithopods' or 'hypsilophodontids' remain poorly resolved since it was discovered that these taxa are not a monophyletic group, but rather a paraphyletic set of neornithischian taxa. Thus, even as the known diversity of these taxa has dramatical...

journal_title：PeerJ

authors： Boyd CA

更新日期：2015-12-22 00:00:00

abstract：:Amazonian bamboo forests dominated by large woody bamboo plants in the genus Guadua cover approximately 180,000 km2 and represent a key resource for many organisms. In southwestern Amazonia, native bamboo forests differ in structure, biodiversity, and growth dynamics from other forest types in the region. However, wit...

journal_title：PeerJ

authors： Jacobs JM,von May R,Kavanaugh DH,Connor EF

更新日期：2018-07-03 00:00:00