VaRank: a simple and powerful tool for ranking genetic variants.

abstract：:Finite Element Analysis (FEA) is a useful method for understanding form and function. However, modelling of fossil taxa invariably involves assumptions as a result of preservation-induced loss of information in the fossil record. To test the validity of predictions from FEA, given such assumptions, these results could...

journal_title：PeerJ

authors： Konietzko-Meier D,Gruntmejer K,Marcé-Nogué J,Bodzioch A,Fortuny J

更新日期：2018-02-26 00:00:00

abstract：Background:Hair follicles in cashmere goats are divided into primary and secondary hair follicles (HFs). HF development, which determines the morphological structure, is regulated by a large number of vital genes; however, the key functional genes and their interaction networks are still unclear. Although the vitamin D...

journal_title：PeerJ

authors： Gao Y,Jin M,Niu Y,Yan H,Zhou G,Chen Y

更新日期：2019-07-03 00:00:00

abstract：Background:Many tilapia species or varieties have been widely introduced and have become an economically important food fish in China. Information on the genetic backgrounds of these populations is deficient and requires more research, especially for red tilapia strains. Methods:In the present study, displacement loop...

journal_title：PeerJ

authors： Jiang B,Fu J,Dong Z,Fang M,Zhu W,Wang L

更新日期：2019-05-29 00:00:00

abstract：Background:This study postulates that underlying environmental conditions and a susceptible population's socio-economic status should be explored simultaneously to adequately understand a vector borne disease infection risk. Here we focus on West Nile Virus (WNV), a mosquito borne pathogen, as a case study for spatial ...

journal_title：PeerJ

authors： Kala AK,Atkinson SF,Tiwari C

更新日期：2020-07-27 00:00:00

abstract：Background:Endometriosis (EMs) is a non-malignant gynecological disease, whose pathogenesis remains to be clarified. Recent studies have found that hypoxia induces epithelial-mesenchymal transition (EMT) as well as epigenetic modification in EMs. However, the relationship between EMT and demethylation modification unde...

journal_title：PeerJ

authors： Wu J,Li X,Huang H,Xia X,Zhang M,Fang X

更新日期：2020-09-15 00:00:00

abstract：:Chronostratigraphic correlation of terrestrial Early Cretaceous biotas in China is highly problematic due to the lack of marine deposits, few absolute dates, and limited number of index fossils. This often leaves vertebrate faunas as one of the few potential tools for a preliminary biostratigraphy. Taxonomic identity ...

journal_title：PeerJ

authors： Li DQ,Zhou CF,Li L,Yang JT,Li L,Rabi M

更新日期：2019-01-15 00:00:00

abstract：:Pseudogymnoascus destructans (Pd), the causative agent of white-nose syndrome in bats (WNS), has led to dramatic declines of bat populations in eastern North America. In the spring of 2016, WNS was first detected at several locations in Washington State, USA, which has prompted the need for large scale surveillance ef...

journal_title：PeerJ

authors： Urbina J,Chestnut T,Schwalm D,Allen J,Levi T

更新日期：2020-01-20 00:00:00

abstract：Background:Ecosystem engineers are species that transform habitats in ways that influence other species.While the impacts of many engineers have been well described, our understanding of how their impact varies along environmental gradients remains limited. Although disentangling the effects of gradients and engineers ...

journal_title：PeerJ

authors： Costa AN,Bruna EM,Vasconcelos HL

更新日期：2018-10-09 00:00:00

abstract：:Irruptions of small consumer populations, driven by pulsed resources, can lead to adverse effects including the decline of indigenous species or increased disease spread. Broad-scale pest management to combat such effects benefits from forecasting of irruptions and an assessment of the optimal control conditions for m...

journal_title：PeerJ

authors： Holland EP,Binny RN,James A

更新日期：2018-12-20 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two late onset neurodegenerative diseases, have been shown to share overlapping cellular pathologies and genetic origins. Studies suggest that a hexanucleotide repeat expansion in the first intron of the C9orf72 gene is the most common cause of fam...

journal_title：PeerJ

authors： Iyer S,Subramanian V,Acharya KR

更新日期：2018-10-17 00:00:00

abstract：Background:Geographic variation in body size and condition can reveal differential local adaptation to resource availability or climatic factors. Body size and condition are related to fitness in garter snakes (Thamnophis), thus good body condition may increase survival, fecundity in females, and mating success in male...

journal_title：PeerJ

authors： Valencia-Flores E,Venegas-Barrera CS,Fajardo V,Manjarrez J

更新日期：2019-03-13 00:00:00

abstract：:Background. Two non-tuberculous mycobacterial strains, UM_3 and UM_11, were isolated from the trunk wash of captive elephants in Malaysia. As they appeared to be identical phenotypes, they were investigated further by conventional and whole genome sequence-based methods of strain differentiation. Methods. Multiphasic ...

journal_title：PeerJ

authors： Chan KG,Loke MF,Ong BL,Wong YL,Hong KW,Tan KH,Kaur S,Ng HF,Abdul Razak M,Ngeow YF

更新日期：2015-11-10 00:00:00

abstract：:Automatic species classification of birds from their sound is a computational tool of increasing importance in ecology, conservation monitoring and vocal communication studies. To make classification useful in practice, it is crucial to improve its accuracy while ensuring that it can run at big data scales. Many appro...

journal_title：PeerJ

authors： Stowell D,Plumbley MD

更新日期：2014-07-17 00:00:00

abstract：:Liver fibrosis often appears in chronic liver disease, with extracellular matrix (ECM) deposition as the main feature. Due to the presence of the liver-gut axis, the destruction of intestinal homeostasis is often accompanied by the development of liver fibrosis. The inconsistent ecological environment of different int...

journal_title：PeerJ

authors： Wan S,Huang C,Wang A,Zhu X

更新日期：2020-04-24 00:00:00

abstract：:The culture of pelagic marine invertebrates, especially the ctenophore Mnemiopsis leidyi, has been demonstrated in past studies dating back to the 1960s; however, the mass culture of delicate pelagic invertebrates has remained elusive. By using a pair of acrylic tubes and enabling water diffusion between them, we have...

journal_title：PeerJ

authors： Patry WL,Bubel M,Hansen C,Knowles T

更新日期：2020-04-07 00:00:00

abstract：:In recent years, a massive mortality event has killed millions of sea stars, of many different species, along the Pacific coast of North America. This disease event, known as 'sea star wasting disease' (SSWD), is linked to viral infection. In one affected sea star (Pisaster ochraceus), previous work had identified tha...

journal_title：PeerJ

authors： Wares JP,Schiebelhut LM

更新日期：2016-03-29 00:00:00

abstract：BACKGROUND:Aspergillus niger, along with many other lignocellulolytic fungi, has been widely used as a commercial workhorse for cellulase production. A fungal cellulase system generally includes three major classes of enzymes i.e., β-glucosidases, endoglucanases and cellobiohydrolases. Cellobiohydrolases (CBH) are vita...

journal_title：PeerJ

authors： Woon JS,Mackeen MM,Illias RM,Mahadi NM,Broughton WJ,Murad AMA,Abu Bakar FD

更新日期：2017-10-12 00:00:00

abstract：Background:The association between asthma (AS), allergic rhinitis (AR) and oral diseases remains inconclusive in adults. AS and AR often coexist. However, studies that investigate AS, AR together and their association with oral diseases are scarce. Methods:Data from 22,898 men and 28,541 women, aged 21 to 25 years, we...

journal_title：PeerJ

authors： Ho SW,Lue KH,Ku MS

更新日期：2019-09-10 00:00:00

abstract：:Background. The ReproQuestionnaire (ReproQ) measures the client's experience with maternity care, following the WHO responsiveness model. In 2015, the ReproQ was appointed as national client experience questionnaire and will be added to the national list of indicators in maternity care. For using the ReproQ in quality...

journal_title：PeerJ

authors： Scheerhagen M,van Stel HF,Tholhuijsen DJ,Birnie E,Franx A,Bonsel GJ

更新日期：2016-07-13 00:00:00

abstract：:Current research posits that all multicellular organisms live in symbioses with associated microorganisms and form so-called metaorganisms or holobionts. Cnidarian metaorganisms are of specific interest given that stony corals provide the foundation of the globally threatened coral reef ecosystems. To gain first insig...

journal_title：PeerJ

authors： Brüwer JD,Voolstra CR

更新日期：2018-03-01 00:00:00

abstract：:The mammalian pelvis is thought to exhibit adaptations to the functional demands of locomotor behaviors. Previous work in primates has identified form-function relationships between pelvic shape and locomotor behavior; few studies have documented such relationships in carnivorans, instead focusing on long bones. Most ...

journal_title：PeerJ

authors： Lewton KL,Brankovic R,Byrd WA,Cruz D,Morales J,Shin S

更新日期：2020-02-20 00:00:00

abstract：:Pseudoterranovosis is a well-known human disease caused by anisakid larvae belonging to the genus Pseudoterranova. Human infection occurs after consuming infected fish. Hence the presence of Pseudoterranova larvae in the flesh of the fish can cause serious losses and problems for the seafood, fishing and fisheries ind...

journal_title：PeerJ

authors： Shamsi S,Suthar J

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Amoebiasis is the third most common parasitic cause of morbidity and mortality, particularly in countries with poor hygienic settings. There exists an ambiguity in the diagnosis of amoebiasis, and hence there arises a necessity for a better diagnostic approach. Serine-rich Entamoeba histolyticaprotein (SREHP...

journal_title：PeerJ

authors： Manochitra K,Parija SC

更新日期：2017-06-28 00:00:00

abstract：:The consumption of raw fish has increased considerably in the West, since it is said to be potentially healthier than processed fish (for containing omega 3 and 6, essential amino acids and vitamins). However this potential benefit, as well as the taste, value and even the risk of extinction are not the same for all s...

journal_title：PeerJ

authors： Staffen CF,Staffen MD,Becker ML,Löfgren SE,Muniz YCN,de Freitas RHA,Marrero AR

更新日期：2017-11-29 00:00:00

abstract：:Triple negative breast cancer (TNBC) is a belligerent carcinoma that is unresponsive to targeted receptor therapies. Development of new treatment strategies would benefit from an expanded repertoire of in vitro cell culture systems, such as those that support tridimensional growth in the presence of hydrogel scaffolds...

journal_title：PeerJ

authors： Jogalekar MP,Serrano EE

更新日期：2018-02-16 00:00:00

abstract：:The maximum likelihood estimation (MLE) method, typically used for polytomous logistic regression, is prone to bias due to both misclassification in outcome and contamination in the design matrix. Hence, robust estimators are needed. In this study, we propose such a method for nominal response data with continuous cov...

journal_title：PeerJ

authors： Wang X

更新日期：2014-07-01 00:00:00

abstract：:The antimicrobial additive triclosan has been used in personal care products widely across the globe for decades. Triclosan resistance has been noted among Vibrio spp., but reports have been anecdotal and the extent of phenotypic triclosan resistance across the Vibrionaceae family has not been established. Here, tricl...

journal_title：PeerJ

authors： Lydon KA,Robertson MJ,Lipp EK

更新日期：2018-07-12 00:00:00

abstract：:According to the intelligence-creativity threshold hypothesis, there should be a positive association between intelligence and creative potential up to a certain point, the threshold, after which a further increase in intelligence should have no association with creativity. In the present simulation study, the measure...

journal_title：PeerJ

authors： Sorjonen K,Ingre M,Melin B

更新日期：2019-10-21 00:00:00

abstract：:The Clarkia lagerstätte (Latah Formation) of Idaho is well known for its beautifully preserved plant fossils as well as a fauna of insects and fish. Here we present the first known tetrapod fossil from these deposits. This specimen, recovered from the lower anoxic zone of the beds, is preserved as a carbonaceous film ...

journal_title：PeerJ

authors： Calede JJM,Orcutt JD,Kehl WA,Richards BD

更新日期：2018-06-08 00:00:00

abstract：:The Eocene history of cetacean evolution is now represented by the expansive fossil record of archaeocetes elucidating major morphofunctional shifts relating to the land to sea transition, but the change from archaeocetes to modern cetaceans is poorly established. New fossil material of the recently recognized family ...

journal_title：PeerJ

authors： Boessenecker RW,Fordyce RE

更新日期：2015-09-10 00:00:00