CRISPR/Cas9-mediated VDR knockout plays an essential role in the growth of dermal papilla cells through enhanced relative genes.

abstract：:Protoporphyrin (PP) and biliverdin (BV) give rise to the enormous diversity in avian egg coloration. Egg color serves several ecological purposes, including post-mating signaling and camouflage. Egg camouflage represents a major character of open-nesting birds which accomplish protection of their unhatched offspring a...

journal_title：PeerJ

authors： Wiemann J,Yang TR,Sander PN,Schneider M,Engeser M,Kath-Schorr S,Müller CE,Sander PM

更新日期：2017-08-29 00:00:00

abstract：:The purpose of this study was to investigate the benefits of exercises with different cognitive demands for cognitive functions (Executive and non-Executive) in healthy older adults. A cross-sectional design was adopted. In total, 84 healthy older adults were enrolled in the study. They were categorized into the Tai C...

journal_title：PeerJ

authors： Ji Z,Li A,Feng T,Liu X,You Y,Meng F,Wang R,Lu J,Zhang C

更新日期：2017-10-20 00:00:00

abstract：:Majority legumes in the temperate and arctic zones have water-impermeable seeds (physical dormancy, PY). However, various authors have reported that seeds of some Caragana species are water-permeable and thus non-dormant. We (1) tested seeds of 15 species of Caragana matured in the same site in 2014, 2016 and/or 2017 ...

journal_title：PeerJ

authors： Chen D,Zhang R,Baskin CC,Hu X

更新日期：2019-05-09 00:00:00

abstract：:Coarse-grained (CG) models have been successful in simulating the chemical properties of lipid bilayers, but accurate treatment of membrane proteins and lipid-protein molecular interactions remains a challenge. The CgProt force field, original developed with the multiscale coarse graining method, is assessed by compar...

journal_title：PeerJ

authors： Hills RD Jr

更新日期：2018-01-10 00:00:00

abstract：BACKGROUND:Parasites are essential components of natural communities, but the factors that generate skewed distributions of parasite occurrences and abundances across host populations are not well understood. METHODS:Here, we analyse at a seascape scale the spatiotemporal relationships of parasite exposure and host bo...

journal_title：PeerJ

authors： Rodríguez SM,Valdivia N

更新日期：2017-08-17 00:00:00

abstract：:Type I restriction-modification enzymes are multisubunit, multifunctional molecular machines that recognize specific DNA target sequences, and their multisubunit organization underlies their multifunctionality. EcoR124I is the archetype of Type I restriction-modification family IC and is composed of three subunit type...

journal_title：PeerJ

authors： Bialevich V,Sinha D,Shamayeva K,Guzanova A,Řeha D,Csefalvay E,Carey J,Weiserova M,Ettrich RH

更新日期：2017-01-18 00:00:00

abstract：Background:Health education can benefit people with chronic diseases. However, in previous research those benefits were small, and reinforcement to maintain them was not effective. A possible explanation is that the benefits appeared to be small and reinforcement appeared to be ineffective because those analyses mixed ...

journal_title：PeerJ

authors： Park MJ,Green J,Jung HS,Park YS

更新日期：2019-07-15 00:00:00

abstract：Background:Plums are a kind of stone fruit, a category that includes peaches, cherries, apricots, and almonds. In Korea, Japanese plum trees are usually cultivated as they best suit the climate. To date, there have been few studies in Korea on viruses infecting plum trees compared to those infecting peach trees. Metho...

journal_title：PeerJ

authors： Jo Y,Choi H,Lian S,Cho JK,Chu H,Cho WK

更新日期：2020-07-29 00:00:00

abstract：:The knowledge on the spatial distribution of soil available water capacity at a regional or national extent is essential, as soil water capacity is a component of the water and energy balances in the terrestrial ecosystem. It controls the evapotranspiration rate, and has a major impact on climate. This paper demonstra...

journal_title：PeerJ

authors： Hong SY,Minasny B,Han KH,Kim Y,Lee K

更新日期：2013-04-23 00:00:00

abstract：:In species that live in one-male groups, resident males monopolize access to a group of females and are assumed to have higher reproductive success than bachelors. We tested this assumption using genetic, demographic, and behavioral data from 8 groups of wild blue monkeys observed over 10 years to quantify reproductio...

journal_title：PeerJ

authors： Roberts SJ,Cords M

更新日期：2015-06-23 00:00:00

abstract：Background:Oral cancer progresses from hyperplastic epithelial lesions through dysplasia to invasive carcinoma. The critical needs in oral cancer treatment are expanding our knowledge of malignant tumour progression and the development of useful approaches to prevent dysplastic lesions. This study was designed to gain ...

journal_title：PeerJ

authors： Ge S,Zhou H,Zhou Z,Liu L,Lou J

更新日期：2021-01-04 00:00:00

abstract：Background:Circadian genes have been suggested to play an important role in lung pathology. However, it remains unknown whether polymorphisms of these genes are associated with chronic obstructive pulmonary disease (COPD). Here, we aimed to investigate the association of circadian genes polymorphisms with COPD in a cas...

journal_title：PeerJ

authors： Chen G,Zhang J,Zhang L,Xiong X,Yu D,Zhang Y

更新日期：2020-08-27 00:00:00

abstract：:The eukaryotic polypyrimidine tract binding protein (PTB) serves primarily as a regulator of alternative splicing of messenger RNA, but is also co-opted to other roles such as RNA localisation and translation initiation from internal ribosome entry sites. The neuronal paralogue of PTB (nPTB) is 75% identical in amino ...

journal_title：PeerJ

authors： Joshi A,Esteve V,Buckroyd AN,Blatter M,Allain FH,Curry S

更新日期：2014-03-13 00:00:00

abstract：Background:Sacbrood virus (SBV) is one of the most pathogenic honeybee viruses that exhibits host specificity and regional variations. The SBV strains that infect the Chinese honeybee Apis cerana are called Chinese SBVs (CSBVs). Methods:In this study, a CSBV strain named AmCSBV-SDLY-2016 (GenBank accession No. MG73328...

journal_title：PeerJ

authors： Li M,Fei D,Sun L,Ma M

更新日期：2019-11-14 00:00:00

abstract：Background:Human population growth has led to biodiversity declines in tropical cities. While habitat loss and fragmentation have been the main drivers of urban biodiversity loss, man-made interventions to reduce health risks have also emerged as an unintentional threat. For instance, insecticide fogging to control mos...

journal_title：PeerJ

authors： Lee NSM,Clements GR,Ting ASY,Wong ZH,Yek SH

更新日期：2020-10-01 00:00:00

abstract：:We examined whether chemically mediated risk perception by prey and the effects of changes in prey behavior on basal resources vary as a function of the amount of prey biomass consumed by the predator. We studied these issues using a tritrophic system composed of blue crabs, Callinectes sapidus (top predator), mud cra...

journal_title：PeerJ

authors： Weissburg M,Beauvais J

更新日期：2015-11-19 00:00:00

abstract：:Cellulosic waste represents a significant and underutilized carbon source for the biofuel industry. Owing to the recalcitrance of crystalline cellulose to enzymatic degradation, it is necessary to design economical methods of liberating the fermentable sugars required for bioethanol production. One route towards unloc...

journal_title：PeerJ

authors： Hamberg Y,Ruimy-Israeli V,Dassa B,Barak Y,Lamed R,Cameron K,Fontes CM,Bayer EA,Fried DB

更新日期：2014-10-30 00:00:00

abstract：:Ovine footrot is a degenerative disease of sheep feet leading to the separation of hoof-horn from the underlying skin and lameness. This study quantitatively examined histological features of the ovine interdigital skin as well as their relationship with pro-inflammatory cytokine (IL-1β) and virulent Dichelobacter nod...

journal_title：PeerJ

authors： Agbaje M,Rutland CS,Maboni G,Blanchard A,Bexon M,Stewart C,Jones MA,Totemeyer S

更新日期：2018-07-02 00:00:00

abstract：:The ubiquitin-proteasome system targets misfolded proteins for degradation. Since the accumulation of such proteins is potentially harmful for the cell, their prompt removal is important. E3 ubiquitin-protein ligases mediate substrate ubiquitination by bringing together the substrate with an E2 ubiquitin-conjugating e...

journal_title：PeerJ

authors： Boomsma W,Nielsen SV,Lindorff-Larsen K,Hartmann-Petersen R,Ellgaard L

更新日期：2016-02-25 00:00:00

abstract：:Metoposaurids are representatives of the extinct amphibian clade Temnospondyli, found on almost every continent exclusively in the Late Triassic deposits. Osteohistologically, it is one of the best-known temnospondyl groups, analyzed with a wide spectrum of methods, such as morphology, morphometry, bone histology or c...

journal_title：PeerJ

authors： Teschner EM,Chakravorti S,Sengupta DP,Konietzko-Meier D

更新日期：2020-09-08 00:00:00

abstract：:Development of mobile sensors brings new opportunities to medical research. In particular, mobile electroencephalography (EEG) devices can be potentially used in low cost screening for epilepsy and other neurological and psychiatric disorders. The necessary condition for such applications is thoughtful validation in t...

journal_title：PeerJ

authors： Kutafina E,Brenner A,Titgemeyer Y,Surges R,Jonas S

更新日期：2020-05-01 00:00:00

abstract：:Wolbachia is an alpha-proteobacterial symbiont widely distributed in arthropods. Since the identification of Wolbachia in certain animal-parasitic nematodes (the Onchocercidae or filariae), the relationship between arthropod and nematode Wolbachia has attracted great interest. The obligate symbiosis in filariae, which...

journal_title：PeerJ

authors： Lefoulon E,Bain O,Makepeace BL,d'Haese C,Uni S,Martin C,Gavotte L

更新日期：2016-03-28 00:00:00

abstract：:Abnormal behaviors in captive animals are generally defined as behaviors that are atypical for the species and are often considered to be indicators of poor welfare. Although some abnormal behaviors have been empirically linked to conditions related to elevated stress and compromised welfare in primates, others have l...

journal_title：PeerJ

authors： Jacobson SL,Ross SR,Bloomsmith MA

更新日期：2016-07-13 00:00:00

abstract：:Background. Neonatal hyperbilirubinemia (HB) may cause severe neurological damage, but serious consequences are effectively controlled by phototherapy and blood exchange transfusion. HB is still a serious health problem in economically compromised parts of the world. The long term outcome has been regarded favorable b...

journal_title：PeerJ

authors： Hokkanen L,Launes J,Michelsson K

更新日期：2014-03-04 00:00:00

abstract：:Recent upperward migration of plants and animals along altitudinal gradients and poleward movement of animal range boundaries have been confirmed by many studies. This phenomenon is considered to be part of the fingerprint of recent climate change on the biosphere. Here I examine whether poleward movement is occurring...

journal_title：PeerJ

authors： Groom QJ

更新日期：2013-05-28 00:00:00

abstract：Background:Supplemental feeding of free-roaming animals, including wildlife and feral or stray animals, is well known to have a substantial impact on various aspects of animal ecology including habitat use, activity patterns, and host-pathogen interactions. Among them, an increased population density (PD) of animals re...

journal_title：PeerJ

authors： Hwang J,Gottdenker NL,Oh DH,Nam HW,Lee H,Chun MS

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:The primary objective of this cross-sectional study was to estimate the crude, seasonal and cull-reason stratified prevalence of Salmonella fecal shedding in cull dairy cattle on seven California dairies. A secondary objective was to estimate and compare the relative sensitivity (Se) and specificity (Sp) for...

journal_title：PeerJ

authors： Abu Aboud OA,Adaska JM,Williams DR,Rossitto PV,Champagne JD,Lehenbauer TW,Atwill R,Li X,Aly SS

更新日期：2016-08-30 00:00:00

abstract：:We describe a new iguanodontian ornithopod, Choyrodon barsboldi gen. et sp. nov. from the Albian-aged Khuren Dukh Formation of Mongolia based on several partial skeletons interpreted to represent a subadult growth stage based on osteohistological features. This new taxon is diagnosed by many autapomorphies of the maxi...

journal_title：PeerJ

authors： Gates TA,Tsogtbaatar K,Zanno LE,Chinzorig T,Watabe M

更新日期：2018-08-03 00:00:00

abstract：:Background. Most genetic disorders are caused by single nucleotide variations (SNVs) or small insertion/deletions (indels). High throughput sequencing has broadened the catalogue of human variation, including common polymorphisms, rare variations or disease causing mutations. However, identifying one variation among h...

journal_title：PeerJ

authors： Geoffroy V,Pizot C,Redin C,Piton A,Vasli N,Stoetzel C,Blavier A,Laporte J,Muller J

更新日期：2015-03-03 00:00:00

abstract：:With rising environmental concerns on potable water safety and eutrophication, increased media attention and tighter environmental regulations, managing animal waste in an environmentally responsible and economically feasible way can be a challenge. In this study, the possibility of using granular anammox process for ...

journal_title：PeerJ

authors： Ni SQ,Yang N

更新日期：2014-04-08 00:00:00