Abstract:
:Liver fibrosis often appears in chronic liver disease, with extracellular matrix (ECM) deposition as the main feature. Due to the presence of the liver-gut axis, the destruction of intestinal homeostasis is often accompanied by the development of liver fibrosis. The inconsistent ecological environment of different intestinal sites may lead to differences in the microbiota. The traditional Chinese medicine ursolic acid (UA) has been proven to protect the liver from fibrosis. We investigated the changes in the microbiota of different parts of the intestine during liver fibrosis and the effect of UA on these changes based on high-throughput sequencing technology. Sequencing results suggest that the diversity and abundance of intestinal microbiota decline and the composition of the microbiota is disordered, the potentially beneficial Firmicutes bacteria are reduced, and the pathways for functional prediction are changed in the ilea and anal faeces of liver fibrosis mice compared with normal mice. However, in UA-treated liver fibrosis mice, these disorders improved. It is worth noting that the bacterial changes in the ilea and anal faeces are not consistent. In conclusion, in liver fibrosis, the microbiota of different parts of the intestines have different degrees of disorder, and UA can improve this disorder. This may be a potential mechanism for UA to achieve anti-fibrosis. This study provides theoretical guidance for the UA targeting of intestinal microbiota for the treatment of liver fibrosis.
journal_name
PeerJjournal_title
PeerJauthors
Wan S,Huang C,Wang A,Zhu Xdoi
10.7717/peerj.9050subject
Has Abstractpub_date
2020-04-24 00:00:00pages
e9050issn
2167-8359pii
9050journal_volume
8pub_type
杂志文章相关文献
PeerJ文献大全abstract::Since 2014, Stony Coral Tissue Loss Disease (SCTLD) has led to mass mortality of the majority of hard coral species on the Florida Reef Tract. Following the successful treatment of SCTLD lesions on laboratory corals using water dosed with antibiotics, two topical pastes were developed as vehicles to directly apply ant...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9289
更新日期:2020-06-09 00:00:00
abstract::Demand for lumpfish (Cyclopterus lumpus) has increased exponentially over the last decade, both for their roe, which is used as a caviar substitute, and increasingly also as cleaner fish to control sea lice in salmon farming. The species is classified as Near Threatened by the IUCN and there are growing concerns that ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5974
更新日期:2018-11-20 00:00:00
abstract::Arbuscular mycorrhizal fungi (AMF) colonization, sampled at 32-50 days post-inoculation (dpi), was significantly reduced in suppressor of prosystemin-mediated responses2 (spr2) mutant tomato plants impaired in the ω-3 FATTY ACID DESATURASE7 (FAD7) gene that limits the generation of linolenic acid and, consequently, th...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8888
更新日期:2020-04-16 00:00:00
abstract:Background:Autonomous Sensory Meridian Response (ASMR) is a sensory experience elicited by auditory and visual triggers, which so far received little attention from the scientific community. This self-reported phenomenon is described as a relaxing tingling sensation, which typically originates on scalp and spreads thro...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5351
更新日期:2018-08-06 00:00:00
abstract:Purpose:Yes associated protein 1 (YAP1), which is a standout amongst the most essential effectors of the Hippo pathway, assumes a vital part in a few kinds of cancer. However, whether YAP1 is an oncogene in CRC (colorectal cancer) remains controversial, and the association between the subcellular localization of YAP1 a...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10397
更新日期:2020-11-19 00:00:00
abstract:Background:The family of true seals, the Phocidae, is subdivided into two subfamilies: the southern Monachinae, and the northern Phocinae, following the subfamilies' current distribution: extant Monachinae are largely restricted to the (sub-)Antarctic and the eastern Pacific, with historical distributions of the monk s...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5734
更新日期:2018-10-09 00:00:00
abstract::A strong argument can be made that the European Union has the most rigorous regulatory system for pesticides in the world, and that modern pesticide use poses fewer environmental threats than older regimes. Nevertheless, the impacts of pesticides on bees and other non-target organisms are much debated in Europe as els...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5255
更新日期:2018-07-19 00:00:00
abstract::In contrast to dominant mode of ecological transition in the evolution of marine mammals, different lineages of toothed whales (Odontoceti) have repeatedly invaded freshwater ecosystems during the Cenozoic era. The so-called 'river dolphins' are now recognized as independent lineages that converged on similar morpholo...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1227
更新日期:2015-09-01 00:00:00
abstract::Wolbachia is an alpha-proteobacterial symbiont widely distributed in arthropods. Since the identification of Wolbachia in certain animal-parasitic nematodes (the Onchocercidae or filariae), the relationship between arthropod and nematode Wolbachia has attracted great interest. The obligate symbiosis in filariae, which...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1840
更新日期:2016-03-28 00:00:00
abstract::Over the last decades several studies have identified that the directional changes in climate induced by anthropogenic emissions of greenhouse gases are affecting the ecology of desert ecosystems. In the Southwest United States, the impacts of climate change to plant abundance and distribution have already been report...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5623
更新日期:2018-09-19 00:00:00
abstract::Background. The ReproQuestionnaire (ReproQ) measures the client's experience with maternity care, following the WHO responsiveness model. In 2015, the ReproQ was appointed as national client experience questionnaire and will be added to the national list of indicators in maternity care. For using the ReproQ in quality...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2092
更新日期:2016-07-13 00:00:00
abstract::Computerised cognitive assessments are a vital tool in the behavioural sciences, but participants often view them as effortful and unengaging. One potential solution is to add gamelike elements to these tasks in order to make them more intrinsically enjoyable, and some researchers have posited that a more engaging tas...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2184
更新日期:2016-07-06 00:00:00
abstract:Background:The Chinese Natural Forest Protection program has been conducted nationwide and has achieved resounding success. However, timber importation has increased; therefore, producing more domestic timber is critical to meet the demand for raw materials. Fertilization is one of the most effective silviculture pract...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4628
更新日期:2018-04-13 00:00:00
abstract::Convergent evolution can provide insights into the predictability of, and constraints on, the evolution of biodiversity. One striking example of convergence is seen in the 'river dolphins'. The four dolphin genera that make up the 'river dolphins' (Inia geoffrensis, Pontoporia blainvillei, Platanista gangetica and Lip...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4090
更新日期:2017-11-21 00:00:00
abstract:Background:Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors in the world, and it has become the leading cause of death of malignant tumors. However, its mechanisms are not fully clear. The aim of this study is to investigate the key genes and explore their potential mechanisms involving in ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8215
更新日期:2019-12-12 00:00:00
abstract:INTRODUCTION:Early detection of social anxiety and loneliness might be useful to prevent substantial impairment in personal relationships. Understanding the way people use smartphones can be beneficial for implementing an early detection of social anxiety and loneliness. This paper examines different types of smartphon...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2197
更新日期:2016-07-12 00:00:00
abstract::In group-living animals, heterogeneity in individuals' social connections may mediate the sharing of microbial infectious agents. In this regard, the genetic relatedness of individuals' commensal gut bacterium Escherichia coli may be ideal to assess the potential for pathogen transmission through animal social network...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4271
更新日期:2018-01-17 00:00:00
abstract::Background. Physical, visual, chemical, and auditory cues signalling fighting ability have independently evolved in many animal taxa as a means to resolve conflicts without escalating to physical aggression. Facial width-to-height ratio (fWHR, i.e., the relative width to height of the face) has been associated with do...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1775
更新日期:2016-03-21 00:00:00
abstract:Background:Sexual development in Flammulina velutipes is controlled by two different mating type loci (HD and PR). The HD locus contains homeodomain (Hd) genes on two separate HD subloci: HD-a and HD-b. While the functionality of the HD-b sublocus has been largely confirmed, the status and content of the HD-a sublocus ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6292
更新日期:2019-02-22 00:00:00
abstract::Afrotheria is a strongly supported clade within placental mammals, but morphological synapomorphies for the entire group have only recently come to light. Soft tissue characters represent an underutilized source of data for phylogenetic analysis, but nonetheless provide features shared by some or all members of Afroth...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1906
更新日期:2016-04-12 00:00:00
abstract:Background:Lysyl oxidases (LOX) have been extensively studied in mammals, whereas properties and functions of recently found homologues in prokaryotic genomes remain enigmatic. Methods:LOX open reading frame was cloned from Haloterrigena turkmenica in an E. coli expression vector. Recombinant Haloterrigena turkmenica ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6691
更新日期:2019-04-05 00:00:00
abstract::Chemical immobilisation is an integral component for the conservation of wild animals and can be stressful if proper protocols are not administered. References on the immobilisation of Arabian striped hyaena (Hyaena hyaena sultana) are scarce. The current study was designed to evaluate the physiological and clinical r...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7326
更新日期:2019-07-26 00:00:00
abstract::Gammaherpesviruses (GHVs) are host specific DNA viruses that infect a large range of mammalian species. These viruses preferentially target host lymphocyte cell populations and infection may lead to morbidity or mortality in immunocompromised, co-infected, or non-adapted hosts. In this study, we tested for the presenc...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4982
更新日期:2018-06-22 00:00:00
abstract:Background:Several heart malformations are associated with mutations in the regulatory regions of cardiac genes. Troponin I type 1b (tnni1b) is important for the formation of the atrioventricular canal in zebrafish hearts; however, the regulation of tnni1b is poorly understand. We aimed to identify a small but function...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10289
更新日期:2020-11-04 00:00:00
abstract::In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having the properties of recognizing specific carbohydrate m...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3784
更新日期:2017-09-07 00:00:00
abstract:Background:Caseinolytic protease P (ClpP), which is located on the inner mitochondrial membrane, degrades mitochondrial proteins damaged by oxidative stress. The role of ClpP varies among tumor types. However, the expression pattern and biological functions of ClpP in breast cancer (BC) have not yet been investigated. ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8754
更新日期:2020-03-10 00:00:00
abstract::I used radio-telemetry to track the movements of Mangrove Cuckoos (Coccyzus minor) captured in southwest Florida. Relatively little is known about the natural history of Mangrove Cuckoos, and my goal was to provide an initial description of how individuals use space, with a focus on the size and placement of home rang...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3534
更新日期:2017-06-30 00:00:00
abstract:Background:Nurses are often the first to activate the chain of survival when a cardiorespiratory arrest happens. That is why it is crucial that they keep their knowledge and skills up-to-date and their attitudes to resuscitation are very important. The main aim of this study was to analyse whether the level of theoreti...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6410
更新日期:2019-02-07 00:00:00
abstract:Background:Reward seeking and avoidance of punishment are key motivational processes. Brain-imaging studies often use the Monetary Incentive Delay Task (MIDT) to evaluate motivational processes involved in maladaptive behavior. Although the bulk of research has been done on the MIDT reward events, little is known about...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4749
更新日期:2018-05-10 00:00:00
abstract::For the past several centuries, millipede taxonomists have used the morphology of male copulatory structures (modified legs called gonopods), which are strongly variable and suggestive of species-level differences, as a source to understand taxon relationships. Millipedes in the family Xystodesmidae are blind, dispers...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3854
更新日期:2017-10-12 00:00:00