PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.

abstract：:The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories. Here we introduce a machine-learning technique-Subtype and Stage Inference (SuStaIn)-able to uncover data-driven...

journal_title：Nature communications

authors： Young AL,Marinescu RV,Oxtoby NP,Bocchetta M,Yong K,Firth NC,Cash DM,Thomas DL,Dick KM,Cardoso J,van Swieten J,Borroni B,Galimberti D,Masellis M,Tartaglia MC,Rowe JB,Graff C,Tagliavini F,Frisoni GB,Laforce R Jr,Fin

更新日期：2018-10-15 00:00:00

abstract：:The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology, but how proteins localize differentially to these structures within a shared cytoplasm remains unclear. Here, we show that the actin-binding domains of accessory proteins can be sensitive to filament conform...

journal_title：Nature communications

authors： Harris AR,Jreij P,Belardi B,Joffe AM,Bausch AR,Fletcher DA

更新日期：2020-11-25 00:00:00

abstract：:The original HTML version of this Article had an incorrect Published online date of 20 March 2019; it should have been 18 March 2019. This has been corrected in the HTML version of the Article. The PDF version was correct from the time of publication. ...

journal_title：Nature communications

authors： Hu Z,Wessels HJCT,van Alen T,Jetten MSM,Kartal B

更新日期：2019-04-18 00:00:00

abstract：:The dynamics of many natural and artificial systems are well described as random walks on a network: the stochastic behaviour of molecules, traffic patterns on the internet, fluctuations in stock prices and so on. The vast literature on random walks provides many tools for computing properties such as steady-state pro...

journal_title：Nature communications

authors： Perkins TJ,Foxall E,Glass L,Edwards R

更新日期：2014-10-14 00:00:00

abstract：:In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice has given insight into cell behavior, but conflicting models appear consistent with the results. Here, we use an additi...

journal_title：Nature communications

authors： Piedrafita G,Kostiou V,Wabik A,Colom B,Fernandez-Antoran D,Herms A,Murai K,Hall BA,Jones PH

更新日期：2020-03-18 00:00:00

abstract：:Two-dimensional nanomaterials such as MoS2 are of great interest both because of their novel physical properties and their applications potential. Liquid exfoliation, an important production method, is limited by our inability to quickly and easily measure nanosheet size, thickness or concentration. Here we demonstrat...

journal_title：Nature communications

authors： Backes C,Smith RJ,McEvoy N,Berner NC,McCloskey D,Nerl HC,O'Neill A,King PJ,Higgins T,Hanlon D,Scheuschner N,Maultzsch J,Houben L,Duesberg GS,Donegan JF,Nicolosi V,Coleman JN

更新日期：2014-08-07 00:00:00

abstract：:Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for reward and motivation, has been implicated in the pathophysiology of depression; however, the afferent source of this increased glutamate tone is not known. The NAc receives glutamatergic inputs from the medial prefrontal cortex ...

journal_title：Nature communications

authors： Bagot RC,Parise EM,Peña CJ,Zhang HX,Maze I,Chaudhury D,Persaud B,Cachope R,Bolaños-Guzmán CA,Cheer JF,Deisseroth K,Han MH,Nestler EJ

更新日期：2015-05-08 00:00:00

abstract：:Respiration by soil bacteria and fungi is one of the largest fluxes of carbon (C) from the land surface. Although this flux is a direct product of microbial metabolism, controls over metabolism and their responses to global change are a major uncertainty in the global C cycle. Here, we explore an in silico approach to...

journal_title：Nature communications

authors： Saifuddin M,Bhatnagar JM,Segrè D,Finzi AC

更新日期：2019-08-08 00:00:00

abstract：:The efficiencies of perovskite solar cells (PSCs) are now reaching such consistently high levels that scalable manufacturing at low cost is becoming critical. However, this remains challenging due to the expensive hole-transporting materials usually employed, and difficulties associated with the scalable deposition of...

journal_title：Nature communications

authors： Wu WQ,Wang Q,Fang Y,Shao Y,Tang S,Deng Y,Lu H,Liu Y,Li T,Yang Z,Gruverman A,Huang J

更新日期：2018-04-24 00:00:00

abstract：:Application of coherent light-matter interactions has recently been extended to the ultrafast control of magnetization. An important but unrealized technique is the manipulation of magnetization vector motion to make it follow an arbitrarily designed multidimensional trajectory. Here we demonstrate a full manipulation...

journal_title：Nature communications

authors： Kanda N,Higuchi T,Shimizu H,Konishi K,Yoshioka K,Kuwata-Gonokami M

更新日期：2011-06-21 00:00:00

abstract：:The sensitivity of quantum magnetometer is challenged by control errors and, especially in the solid state, by their short coherence times. Refocusing techniques can overcome these limitations and improve the sensitivity to periodic fields, but they come at the cost of reduced bandwidth and cannot be applied to sense ...

journal_title：Nature communications

authors： Aiello CD,Hirose M,Cappellaro P

更新日期：2013-01-01 00:00:00

abstract：:Networks of natural protein nanofibrils, such as cytoskeletal filaments, control the shape and the division of cells, yet mimicking this functionality in a synthetic setting has proved challenging. Here, we demonstrate that artificial networks of protein nanofibrils can induce controlled deformation and division of al...

journal_title：Nature communications

authors： Song Y,Michaels TCT,Ma Q,Liu Z,Yuan H,Takayama S,Knowles TPJ,Shum HC

更新日期：2018-05-29 00:00:00

abstract：:Plant halogenated natural products are rare and harbor various interesting bioactivities, yet the biochemical basis for the involved halogenation chemistry is unknown. While a handful of Fe(II)- and 2-oxoglutarate-dependent halogenases (2ODHs) have been found to catalyze regioselective halogenation of unactivated C-H ...

journal_title：Nature communications

authors： Kim CY,Mitchell AJ,Glinkerman CM,Li FS,Pluskal T,Weng JK

更新日期：2020-04-20 00:00:00

abstract：:The Unc-51 like autophagy activating kinase 1 (ULK1) complex plays a central role in the initiation stage of autophagy. However, the function of ULK1 in the late stage of autophagy is unknown. Here, we report that ULK1, a central kinase of the ULK1 complex involved in autophagy initiation, promotes autophagosome-lysos...

journal_title：Nature communications

authors： Wang C,Wang H,Zhang D,Luo W,Liu R,Xu D,Diao L,Liao L,Liu Z

更新日期：2018-08-28 00:00:00

abstract：:Synapse formation is triggered through trans-synaptic interaction between pairs of pre- and postsynaptic adhesion molecules, the specificity of which depends on splice inserts known as 'splice-insert signaling codes'. Receptor protein tyrosine phosphatase δ (PTPδ) can bidirectionally induce pre- and postsynaptic diffe...

journal_title：Nature communications

authors： Yamagata A,Yoshida T,Sato Y,Goto-Ito S,Uemura T,Maeda A,Shiroshima T,Iwasawa-Okamoto S,Mori H,Mishina M,Fukai S

更新日期：2015-04-24 00:00:00

abstract：:Inelastic collisions involving molecular species are key to energy transfer in gaseous environments. They are commonly governed by an energy gap law, which dictates that transitions are dominated by those between initial and final states with roughly the same ro-vibrational energy. Transitions involving rotational ine...

journal_title：Nature communications

authors： Yang D,Huang J,Hu X,Guo H,Xie D

更新日期：2019-10-11 00:00:00

abstract：:Trafficking of mitochondria into dendrites and axons plays an important role in the physiology and pathophysiology of neurons. Mitochondrial outer membrane protein Miro and adaptor proteins TRAKs/Milton link mitochondria to molecular motors. Here we show that metaxins MTX-1 and MTX-2 contribute to mitochondrial transp...

journal_title：Nature communications

authors： Zhao Y,Song E,Wang W,Hsieh CH,Wang X,Feng W,Wang X,Shen K

更新日期：2021-01-04 00:00:00

abstract：:The Clp protease complex degrades a multitude of substrates, which are engaged by a AAA+ chaperone such as ClpX and subsequently digested by the dynamic, barrel-shaped ClpP protease. Acyldepsipeptides (ADEPs) are natural product-derived antibiotics that activate ClpP for chaperone-independent protein digestion. Here w...

journal_title：Nature communications

authors： Gersch M,Famulla K,Dahmen M,Göbl C,Malik I,Richter K,Korotkov VS,Sass P,Rübsamen-Schaeff H,Madl T,Brötz-Oesterhelt H,Sieber SA

更新日期：2015-02-19 00:00:00

abstract：:Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in the lung. Lung immune sign...

journal_title：Nature communications

authors： Singhania A,Graham CM,Gabryšová L,Moreira-Teixeira L,Stavropoulos E,Pitt JM,Chakravarty P,Warnatsch A,Branchett WJ,Conejero L,Lin JW,Davidson S,Wilson MS,Bancroft G,Langhorne J,Frickel E,Sesay AK,Priestnall SL,Herbert

更新日期：2019-06-28 00:00:00

abstract：:The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs...

journal_title：Nature communications

authors： Miyawaki S,Kawamura Y,Oiwa Y,Shimizu A,Hachiya T,Bono H,Koya I,Okada Y,Kimura T,Tsuchiya Y,Suzuki S,Onishi N,Kuzumaki N,Matsuzaki Y,Narita M,Ikeda E,Okanoya K,Seino K,Saya H,Okano H,Miura K

更新日期：2016-05-10 00:00:00

abstract：:Monolayer chalcogenide semiconductors with both luminescent and ferromagnetic properties are dreamed for simultaneous polarization and detection of the valley degree of freedom in valleytronics. However, a conventional chalcogenide monolayer lacks these coexisting properties due to their mutually exclusive origins. He...

journal_title：Nature communications

authors： Duan H,Guo P,Wang C,Tan H,Hu W,Yan W,Ma C,Cai L,Song L,Zhang W,Sun Z,Wang L,Zhao W,Yin Y,Li X,Wei S

更新日期：2019-04-05 00:00:00

abstract：:Ribosomal RNA (rRNA) is most highly expressed in rapidly growing bacteria and is drastically downregulated under stress conditions by the global transcriptional regulator DksA and the alarmone ppGpp. Here, we determined cryo-electron microscopy structures of the Escherichia coli RNA polymerase (RNAP) σ70 holoenzyme du...

journal_title：Nature communications

authors： Shin Y,Qayyum MZ,Pupov D,Esyunina D,Kulbachinskiy A,Murakami KS

更新日期：2021-01-22 00:00:00

abstract：:Samarium hexaboride is a classic three-dimensional mixed valence system with a high-temperature metallic phase that evolves into a paramagnetic charge insulator below 40 K. A number of recent experiments have suggested the possibility that the low-temperature insulating bulk hosts electrically neutral gapless fermioni...

journal_title：Nature communications

authors： Chowdhury D,Sodemann I,Senthil T

更新日期：2018-05-02 00:00:00

abstract：:Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank), we here show that ...

journal_title：Nature communications

authors： Joshi PK,Fischer K,Schraut KE,Campbell H,Esko T,Wilson JF

更新日期：2016-03-31 00:00:00

abstract：:Scattering-type scanning near-field optical microscopy (s-SNOM) allows spectroscopic imaging with spatial resolution below the diffraction limit. With suitable light sources, s-SNOM is instrumental in numerous discoveries at the nanoscale. So far, the light sources have been limited to continuous wave or high-repetiti...

journal_title：Nature communications

authors： Wang H,Wang L,Xu XG

更新日期：2016-10-17 00:00:00

abstract：:The continued convergence of electronics and photonics on the chip scale can benefit from the voltage control of optical polarization for applications in communications, signal processing and sensing. It is challenging, however, to electrically manipulate the polarization state of light in planar optical waveguides. H...

journal_title：Nature communications

authors： Xu Q,Chen L,Wood MG,Sun P,Reano RM

更新日期：2014-11-12 00:00:00

abstract：:Development of sensitive local probes of magnon dynamics is essential to further understand the physical processes that govern magnon generation, propagation, scattering, and relaxation. Quantum spin sensors like the NV center in diamond have long spin lifetimes and their relaxation can be used to sense magnetic field...

journal_title：Nature communications

authors： McCullian BA,Thabt AM,Gray BA,Melendez AL,Wolf MS,Safonov VL,Pelekhov DV,Bhallamudi VP,Page MR,Hammel PC

更新日期：2020-10-16 00:00:00

abstract：:Reliable prediction of seasonal precipitation in the southwestern US (SWUS) remains a challenge with significant implications for the economy, water security and ecosystem management of the region. Winter precipitation in the SWUS has been linked to several climate modes, including the El Niño-Southern Oscillation (EN...

journal_title：Nature communications

authors： Mamalakis A,Yu JY,Randerson JT,AghaKouchak A,Foufoula-Georgiou E

更新日期：2018-06-13 00:00:00

abstract：:The mesopelagic (200-1000 m) separates the productive upper ocean from the deep ocean, yet little is known of its long-term dynamics despite recent research that suggests fishes of this zone likely dominate global fish biomass and contribute to the downward flux of carbon. Here we show that mesopelagic fishes dominate...

journal_title：Nature communications

authors： Jones WA,Checkley DM Jr

更新日期：2019-10-08 00:00:00

abstract：:The emergence of antibiotic resistant bacteria is a major threat to the practice of modern medicine. Photobactericidal agents have obtained significant attention as promising candidates to kill bacteria, and they have been extensively studied. However, to obtain photobactericidal activity, an intense white light sourc...

journal_title：Nature communications

authors： Hwang GB,Huang H,Wu G,Shin J,Kafizas A,Karu K,Toit HD,Alotaibi AM,Mohammad-Hadi L,Allan E,MacRobert AJ,Gavriilidis A,Parkin IP

更新日期：2020-03-05 00:00:00