Abstract:
:Metachromatic leukodystrophy disorder (MLD) is an autosomal recessive and lysosomal storage disease. The disease is caused by the deficiency of the enzyme arylsulfatase A (ARSA) which is encoded by the ARSA gene. Different mutations have been reported in different populations. The present study was aimed to detect the mutation type of the ARSA gene in three relative Iranian patients. We found a novel homozygous missense mutation c.1070 G > T (p.Gly357Val) in exon 6 of these patients. The mutation was found to be reported for the first time in MLD patients. The data can update the mutation profile and contribute toward improved clinical management and counseling of MLD patients.
journal_name
Genet Mol Bioljournal_title
Genetics and molecular biologyauthors
Golchin N,Hajjari M,Malamiri RA,Aminzadeh M,Mohammadi-Asl Jdoi
10.1590/1678-4685-GMB-2016-0110subject
Has Abstractpub_date
2017-10-01 00:00:00pages
759-762issue
4eissn
1415-4757issn
1678-4685pii
S1415-47572017005027101journal_volume
40pub_type
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