Abstract:
:Hereditary cancer risk assessment is a multidisciplinary and dynamic process, with the purpose of estimating probabilities of germline mutations in cancer susceptibility genes and assessing empiric risks of cancer based on personal and family histories, in order to offer clinical and molecular diagnoses and clinical management based on these risks. Genetic tests are available and most of them are reimbursed by insurance companies, although they are generally not covered by the public health systems of developing countries. More recently, molecular diagnosis of hereditary cancer is feasible through next-generation sequencing (NGS) panels. Here we review the benefits and limitations of NGS technologies in the clinical practice.
journal_name
Genet Mol Bioljournal_title
Genetics and molecular biologyauthors
Gomy I,Diz Mdel Pdoi
10.1590/1678-4685-GMB-2014-0346subject
Has Abstractpub_date
2016-05-13 00:00:00pages
184-8issue
2eissn
1415-4757issn
1678-4685pii
S1415-47572016005001102journal_volume
39pub_type
杂志文章abstract::Up-regulation of human endogenous retroviruses (HERVs) is associated with many diseases, including cancer. In this study, an H family HERV (HERV-H)-related gene was identified and characterized. Its spliced transcript lacks protein-coding capacity and may belong to the emerging class of noncoding RNAs (ncRNAs). The 1....
journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
pub_type: 杂志文章
doi:10.1590/1678-4685-GMB-2015-0192
更新日期:2016-07-01 00:00:00
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
pub_type: 杂志文章
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journal_title:Genetics and molecular biology
pub_type: 杂志文章
doi:10.1590/S1415-47572012000300007
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journal_title:Genetics and molecular biology
pub_type: 杂志文章
doi:10.1590/S1415-47572013000400015
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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更新日期:2019-01-01 00:00:00
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
pub_type: 杂志文章
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journal_title:Genetics and molecular biology
pub_type: 杂志文章
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journal_title:Genetics and molecular biology
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更新日期:2011-04-01 00:00:00
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
pub_type: 杂志文章
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