Abstract:
:Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.
journal_name
Genet Mol Bioljournal_title
Genetics and molecular biologyauthors
Hoch NC,Polo LMdoi
10.1590/1678-4685-GMB-2019-0075subject
Has Abstractpub_date
2019-12-13 00:00:00pages
e20190075issue
1 suppl 1eissn
1415-4757issn
1678-4685pii
S1415-47572020000200304journal_volume
43pub_type
杂志文章abstract::Up-regulation of human endogenous retroviruses (HERVs) is associated with many diseases, including cancer. In this study, an H family HERV (HERV-H)-related gene was identified and characterized. Its spliced transcript lacks protein-coding capacity and may belong to the emerging class of noncoding RNAs (ncRNAs). The 1....
journal_title:Genetics and molecular biology
pub_type: 杂志文章
doi:10.1590/S1415-47572009005000082
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
pub_type: 杂志文章
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更新日期:2020-02-10 00:00:00
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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journal_title:Genetics and molecular biology
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