abstract：:Blood methylated cell-free DNA (cfDNA) as a minimally invasive cancer biomarker has great importance in cancer management. Guanylate binding protein 2 (GBP2) has been considered as a possible controlling factor in tumor development. GBP2 gene expression and its promoter methylation status in both plasma cfDNA and tumo...

journal_title：Genetics and molecular biology

authors： Rahvar F,Salimi M,Mozdarani H

更新日期：2020-11-17 00:00:00

abstract：:The freshwater family Siluridae occurs in Eurasia and is especially speciose in South and Southeast Asia, representing an important aquaculture and fishery targets. However, despite the restricted cytogenetic data, a high diploid number variation (from 2n=40 to 92) characterizes this fish group. Considering the large ...

journal_title：Genetics and molecular biology

authors： Ditcharoen S,Sassi FMC,Bertollo LAC,Molina WF,Liehr T,Saenjundaeng P,Tanomtong A,Supiwong W,Suwannapoom C,Cioffi MB

更新日期：2020-11-06 00:00:00

abstract：:Rabies is a fatal zoonotic infection of the central nervous system of mammals and has been known to humans for millennia. The etiological agent, is a neurotropic RNA virus in the order Mononegavirales, family Rhabdoviridae, genus Lyssavirus. There are currently accepted to be two cycles for rabies transmission: the ur...

journal_title：Genetics and molecular biology

authors： Oliveira RN,Freire CC,Iamarino A,Zanotto PM,Pessoa R,Sanabani SS,Souza SP,Castilho JG,Batista HBCR,Carnieli P Jr,Macedo CI,Watanabe JT,Brandão PE

更新日期：2020-07-31 00:00:00

abstract：:MicroRNAs are considered as potential biomarkers, agents, or therapeutic targets; few studies have addressed the expression of miRNAs in treatment-naïve patients infected with HIV-1. The aim of this study was to assess plasma relative circulating miRNA expression profiles in treatment-naïve Mexican patients with HIV/A...

journal_title：Genetics and molecular biology

authors： Cárdenas-Bedoya J,Marquez-Pedroza J,Morán-Moguel MC,Escoto-Delgadillo M,Vázquez-Valls E,González-Enríquez GV,Pérez-Ríos AM,Torres-Mendoza BM

更新日期：2020-06-22 00:00:00

abstract：:Tsetse flies are responsible for the transmission of Trypanossoma sp. to vertebrate animals in Africa causing huge health issues and economic loss. The availability of the genome sequence of Glossina morsitans enabled the discovery of several genes related to medically important phenotypes and novel physiological feat...

journal_title：Genetics and molecular biology

authors： Freitas L,Mesquita RD,Schrago CG

更新日期：2020-06-10 00:00:00

abstract：:Population genetics studies the distributions and changes in population allele frequencies in response to processes, such as mutation, natural selection, gene flow, and genetic drift. Researchers daily manage genetic, biological, and environmental data of the samples, storing them in text files or spreadsheets, which ...

journal_title：Genetics and molecular biology

authors： Elias DE,Rueda ECR

更新日期：2020-05-29 00:00:00

abstract：:Phylogenetic species of Paracoccidioides brasiliensis complex (S1a and S1b, PS2, PS3, and PS4) and Paracoccidioides lutzii are agents of paracoccidioidomycosis, an endemic fungal disease in Latin America. P. restrepiensis (PS3 genotype) was classified as monophyletic and geographically restricted to Colombia and neigh...

journal_title：Genetics and molecular biology

authors： Cocio TA,Nascimento E,Kress MRVZ,Bagagli E,Martinez R

更新日期：2020-05-29 00:00:00

abstract：:4-Coumaric acid: coenzyme A ligase (4CL) is a key enzyme in the phenylpropanoid metabolic pathway that regulates the biosynthesis of lignin and flavonoids. Therefore, the study of 4CL is important to explore the accumulation and regulation of metabolites. This study investigated the role that the 4CL2 gene from Dryopt...

journal_title：Genetics and molecular biology

authors： Li SS,Chang Y,Li B,Shao SL,Zhen-Zhu- Z

更新日期：2020-05-20 00:00:00

abstract：:Phylogenetic niche conservatism can be investigated at multiple scales on an explicit geographical context. Haplotype-based comparative analyses of lineages occupying the same region, and thus subjected to similar environmental factors, allow decoupling shared evolutionary and ecological patterns, as well as multiple ...

journal_title：Genetics and molecular biology

authors： Barros MJF,Silva-Arias GA,Segatto ALA,Reck-Kortmann M,Fregonezi JN,Diniz-Filho JAF,Freitas LB

更新日期：2020-04-27 00:00:00

abstract：:Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not only the quantity but also the quality (alternative isoforms) of their transc...

journal_title：Genetics and molecular biology

authors： Botto AEC,Muñoz JC,Giono LE,Nieto-Moreno N,Cuenca C,Kornblihtt AR,Muñoz MJ

更新日期：2020-03-27 00:00:00

abstract：:Despite the richness of species in the Hirudinidae family, little is known about the genome organization of swallows. The Progne tapera species presents genetic and morphological difference when compared to other members of the same genus. Hence, the aims of this study were to analyze the chromosomal evolution of thre...

journal_title：Genetics and molecular biology

authors： Barcellos SA,Kretschmer R,Souza MS,Costa AL,Degrandi TM,Lopes CF,Ferguson-Smith MA,Pereira J,Oliveira EHC,Gunski RJ,Garnero ADV

更新日期：2020-03-09 00:00:00

abstract：:Birth defects (BDs) are functional and structural alterations in embryonic or fetal development. With an incidence of approximately 3-5%, BDs are a leading cause of infant mortality and lifelong disability. A population-based prospective case-control study was conducted for one year with 5204 infants, between March 1s...

journal_title：Genetics and molecular biology

authors： Oliveira-Brancati CIF,Ferrarese VCC,Costa AR,Fett-Conte AC

更新日期：2020-02-10 00:00:00

abstract：:Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present ...

journal_title：Genetics and molecular biology

authors： Hoch NC,Polo LM

更新日期：2019-12-13 00:00:00

abstract：:Autochthonous pig breeds represent an important genetic reserve to be utilized mainly for the production of typical products. To explore its genetic variability, here we present for the first time whole genome sequencing data and SNPs discovered in a male domestic Nero Siciliano pig compared to the last pig reference ...

journal_title：Genetics and molecular biology

authors： D'Alessandro E,Giosa D,Sapienza I,Giuffrè L,Cigliano RA,Romeo O,Zumbo A

更新日期：2019-07-01 00:00:00

abstract：:The aim of this study was to evaluate the impact and mechanism of co-blocking of costimulatory signals CD28-B7-CD40-CD40L during immune allograft rejection. Forty-eight recipient rabbits were prepared as a high-risk corneal allograft model. After surgery, the animals were randomly divided into: control group, MR1 grou...

journal_title：Genetics and molecular biology

authors： Zhao HX,Li XY,Guan WY,Han XT

更新日期：2019-04-01 00:00:00

abstract：:Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs115688...

journal_title：Genetics and molecular biology

authors： Silva RCD,Alves NMP,Pereira JJS,Coelho AVC,Arraes LC,Brandão LAC,Crovella S,Silva JA

更新日期：2019-04-01 00:00:00

abstract：:SPLs are plant-specific transcription factors that play important regulatory roles in plant growth and development. Systematic analysis of the SPL family has been performed in numerous plants, such as Arabidopsis, rice, and Populus. However, no comparative analysis has been performed across different species to examin...

journal_title：Genetics and molecular biology

authors： Peng X,Wang Q,Zhao Y,Li X,Ma Q

更新日期：2019-04-01 00:00:00

abstract：:Oral Lichen Planus (OLP) is an oral inflammatory condition, mediated by host immune system reaction, presenting basal membrane damages with inflammatory lesions in the mouth and/or skin. In this study, the role of functional polymorphisms in the MBL2 gene, encoding for Mannose-Binding Protein C (MBP-C), a member of th...

journal_title：Genetics and molecular biology

authors： Polesello V,Segat L,Biasotto M,Ottaviani G,Gobbo M,Di Lenarda R,Crovella S,Zupin L

更新日期：2019-01-01 00:00:00

abstract：:Treatment of moderate and severe forms of osteogenesis imperfecta (OI) with cyclic pamidronate at the Reference Center for OI Treatment in Southern Brazil was studied. A retrospective cohort study was conducted from 2002 to 2012. Data were obtained during inpatient (drug infusion) and outpatient care. Clinical data, i...

journal_title：Genetics and molecular biology

authors： Pinheiro B,Zambrano MB,Vanz AP,Brizola E,Souza LT,Félix TM

更新日期：2019-01-01 00:00:00

abstract：:Glucose-6-phosphate dehydrogenase deficiency (G6PDd) and Duffy-negative blood group are two red blood cells variants that confer protection against malaria. In this study, the distribution of the most common G6PD variants (G6PD*A-, GGPD*A and G6PD Mediterranean) and the major alleles of the Duffy blood group (FY*A, FY...

journal_title：Genetics and molecular biology

authors： Oliveira HSS,Silva ANLMD,Andrade GB,Gaia KC,Costa GLC,Santos ÂKCRD,Guerreiro JF

更新日期：2018-10-01 00:00:00

abstract：:The goal of this research was to investigate the linkage disequilibrium between rs9263726 and HLA-B*58:01 in different Chinese ethnic groups (Han, Tibet, and Hui) and to study the feasibility of rs9263726 replacing HLA-B*58:01 as an efficient indicator of potential allopurinol hypersensitivity syndrome. In this study,...

journal_title：Genetics and molecular biology

authors： Zhang X,Jin L,Wu Z,Ma W,Chen Y,Chen G,Wang L,Guan M

更新日期：2018-07-01 00:00:00

abstract：:DNA barcoding helps to identify species, especially when identification is based on parts of organisms or life stages such as seeds, pollen, wood, roots or juveniles. However, the implementation of this approach strongly depends on the existence of complete reference libraries of DNA sequences. If such a library is in...

journal_title：Genetics and molecular biology

authors： Lima RAF,Oliveira AA,Colletta GD,Flores TB,Coelho RLG,Dias P,Frey GP,Iribar A,Rodrigues RR,Souza VC,Chave J

更新日期：2018-07-01 00:00:00

abstract：:Lupinus albescens is a resistant cover plant that establishes symbiotic relationships with bacteria belonging to the Bradyrhizobium genus. This symbiosis helps the development of these plants in adverse environmental conditions, such as the ones found in arenized areas of Southern Brazil. This work studied three Brady...

journal_title：Genetics and molecular biology

authors： Granada CE,Vargas LK,Sant'Anna FH,Balsanelli E,Baura VA,Oliveira Pedrosa F,Souza EM,Falcon T,Passaglia LMP

更新日期：2018-04-01 00:00:00

abstract：:The importance of glutathione (GSH) in alternative cellular roles to the canonically proposed, were analyzed in a model unable to synthesize GSH. Gene expression analysis shows that the regulation of the actin cytoskeleton pathway is strongly impacted by the absence of GSH. To test this hypothesis, we evaluate the eff...

journal_title：Genetics and molecular biology

authors： Zepeta-Flores N,Valverde M,Lopez-Saavedra A,Rojas E

更新日期：2018-04-01 00:00:00

abstract：:Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the associ...

journal_title：Genetics and molecular biology

authors： Silva-Sena GG,Camporez D,Santos LRD,Silva ASD,Sagrillo Pimassoni LH,Tieppo A,Pimentel Batitucci MDC,Morelato RL,Paula F

更新日期：2018-04-01 00:00:00

abstract：:Alcohol dehydrogenases belong to the large superfamily of medium-chain dehydrogenases/reductases, which occur throughout the biological world and are involved with many important metabolic routes. We considered the phylogeny of 190 ADH sequences of animals, fungi, and plants. Non-class III Caenorhabditis elegans ADHs ...

journal_title：Genetics and molecular biology

authors： Thompson CE,Freitas LB,Salzano FM

更新日期：2018-01-01 00:00:00

abstract：:This study aimed to use gene chips to investigate differential gene expression profiles in the occurrence and development of acute myocardial infarction (AMI). The study included 12 AMI patients and 12 healthy individuals. Total mRNA of peripheral bloodwas extracted and reversed-transcribed to cDNA for microarray anal...

journal_title：Genetics and molecular biology

authors： Fan L,Meng H,Guo X,Li X,Meng F

更新日期：2018-01-01 00:00:00

abstract：:This study shows that sampling maternal DNA from hatched and abandoned eggshells is a viable noninvasive strategy for studying the genetics of rare or endangered tropical birds, as exemplified here by the Brazilian Merganser (Mergus octosetaceus). Eighteen microsatellites were isolated from enriched libraries and nine...

journal_title：Genetics and molecular biology

authors： Maia TA,Vilaça ST,Silva LRD,Santos FR,Dantas GPM

更新日期：2017-10-01 00:00:00

abstract：:The development of conventional, silicon-based computers has several limitations, including some related to the Heisenberg uncertainty principle and the von Neumann "bottleneck". Biomolecular computers based on DNA and proteins are largely free of these disadvantages and, along with quantum computers, are reasonable a...

journal_title：Genetics and molecular biology

authors： Sakowski S,Krasinski T,Waldmajer J,Sarnik J,Blasiak J,Poplawski T

更新日期：2017-10-01 00:00:00

abstract：:Metachromatic leukodystrophy disorder (MLD) is an autosomal recessive and lysosomal storage disease. The disease is caused by the deficiency of the enzyme arylsulfatase A (ARSA) which is encoded by the ARSA gene. Different mutations have been reported in different populations. The present study was aimed to detect the...

journal_title：Genetics and molecular biology

authors： Golchin N,Hajjari M,Malamiri RA,Aminzadeh M,Mohammadi-Asl J

更新日期：2017-10-01 00:00:00

abstract：:The function of gene body DNA methylation in alternative splicing, and its relation to disease pathogenesis is not fully elucidated. The gene for familial Mediterranean fever (MEFV) encodes the pyrin protein and contains a 998 bp CpG island, covering the second exon, which is differentially methylated in FMF patients ...

journal_title：Genetics and molecular biology

authors： Erdem GC,Erdemir S,Abaci I,Aydin AKK,Everest E,Turanli ET

更新日期：2017-07-01 00:00:00

abstract：:Tissue samples from mosquitoes artificially infected with Zika virus and shown to be positive by RT-qPCR were reexamined by RT-PCR. Using these samples we compared the two methods employed in virus RNA detection for vector competence studies. Results demonstrated that, albeit useful, RT-PCR gave false negatives with l...

journal_title：Genetics and molecular biology

authors： Paiva MHS,Guedes DRD,Leal WS,Ayres CFJ

更新日期：2017-07-01 00:00:00

abstract：:The Morato's Digger Toad, Proceratophrys moratoi, is a critically endangered toad species with a marked population decline in southern Brazilian Cerrado. Despite this, new populations are being discovered, primarily in the northern part of the distribution range, which raises a number of questions with regard to the c...

journal_title：Genetics and molecular biology

authors： Arruda MP,Costa WP,Recco-Pimentel SM

更新日期：2017-04-01 00:00:00

abstract：:Oryza sativa, the common cultivated rice, is one of the most important crops for human consumption, but production is increasingly threatened by abiotic stresses. Although many efforts have resulted in breeding rice cultivars that are relatively tolerant to their local environments, climate changes and population incr...

journal_title：Genetics and molecular biology

authors： Menguer PK,Sperotto RA,Ricachenevsky FK

更新日期：2017-01-01 00:00:00

abstract：:Since the first diacylglycerol acyltransferase (DGAT) gene was characterized in plants, a number of studies have focused on understanding the role of DGAT activity in plant triacylglycerol (TAG) biosynthesis. DGAT enzyme is essential in controlling TAGs synthesis and is encoded by different genes. DGAT1 and DGAT2 are ...

journal_title：Genetics and molecular biology

authors： Turchetto-Zolet AC,Christoff AP,Kulcheski FR,Loss-Morais G,Margis R,Margis-Pinheiro M

更新日期：2016-10-01 00:00:00

abstract：:Exercise is a double-edged sword: when practiced in moderation, it increases the expression of antioxidant enzymes, but when practiced strenuously it causes oxidative stress and cell damage. In this context, polymorphisms in the interleukin (IL)-6 gene should be investigated better because they can influence performan...

journal_title：Genetics and molecular biology

authors： Miranda-Vilela AL,Ribeiro IF,Grisolia CK

更新日期：2016-10-01 00:00:00

abstract：:Hereditary Sensory and Autonomic Neuropathies (HSANs) compose a heterogeneous group of genetic disorders characterized by sensory and autonomic dysfunctions. Familial Dysautonomia (FD), also known as HSAN III, is an autosomal recessive disorder that affects 1/3,600 live births in the Ashkenazi Jewish population. The m...

journal_title：Genetics and molecular biology

authors： Dietrich P,Dragatsis I

更新日期：2016-10-01 00:00:00

abstract：:The D-genome progenitor of wheat (Triticum aestivum), Aegilops tauschii, possesses numerous genes for resistance to abiotic stresses, including drought. Therefore, information on the genetic architecture of A. tauschii can aid the development of drought-resistant wheat varieties. Here, we evaluated 13 traits in 373 A....

journal_title：Genetics and molecular biology

authors： Qin P,Lin Y,Hu Y,Liu K,Mao S,Li Z,Wang J,Liu Y,Wei Y,Zheng Y

更新日期：2016-07-01 00:00:00

abstract：:Catalase (CAT) is a common antioxidant enzyme in almost all living organisms. Currently, detailed reports on cucumber (Cucumis sativus L.) CAT (CsCAT) genes and tissue expression profiling are limited. In the present study, four candidate CsCAT genes were identified in cucumber. Phylogenetic analysis indicated that Cs...

journal_title：Genetics and molecular biology

authors： Hu L,Yang Y,Jiang L,Liu S

更新日期：2016-07-01 00:00:00

abstract：:Hereditary cancer risk assessment is a multidisciplinary and dynamic process, with the purpose of estimating probabilities of germline mutations in cancer susceptibility genes and assessing empiric risks of cancer based on personal and family histories, in order to offer clinical and molecular diagnoses and clinical m...

journal_title：Genetics and molecular biology

authors： Gomy I,Diz Mdel P

更新日期：2016-05-13 00:00:00