Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study.

Abstract:

:Exercise is a double-edged sword: when practiced in moderation, it increases the expression of antioxidant enzymes, but when practiced strenuously it causes oxidative stress and cell damage. In this context, polymorphisms in the interleukin (IL)-6 gene should be investigated better because they can influence performance, at least in exercise that generates oxidative stress and leads to muscular injuries with consequent inflammation. In this work, we investigated the influence of IL-6 -174 G/C polymorphism on tissue damage and inflammation markers, lipid peroxidation, hemogram and lipid profile of runners before and after ingestion of 400 mg of pequi oil in capsules supplied daily for 14 consecutive days. The IL-6 genotypes were associated with significant differences in lipid peroxidation, with the CC mutant having lower values. There were also significant differences among these genotypes in the response to supplementation with pequi oil, exercise-induced damage and C-reactive protein (CRP) levels. The best protection against damage was observed with the heterozygous genotype. Although the CC genotype showed an increase in CRP levels after supplementation, the lack of a positive correlation between triglycerides and high-sensitivity CRP in this mutant genotype after supplementation indicated a protective effect of pequi. These findings deserve further investigation, particularly with regard to the quantification of circulating IL-6 concentrations.

journal_name

Genet Mol Biol

authors

Miranda-Vilela AL,Ribeiro IF,Grisolia CK

doi

10.1590/1678-4685-GMB-2015-0299

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

554-566

issue

4

eissn

1415-4757

issn

1678-4685

pii

S1415-47572016005014101

journal_volume

39

pub_type

杂志文章
  • Hereditary cancer risk assessment: insights and perspectives for the Next-Generation Sequencing era.

    abstract::Hereditary cancer risk assessment is a multidisciplinary and dynamic process, with the purpose of estimating probabilities of germline mutations in cancer susceptibility genes and assessing empiric risks of cancer based on personal and family histories, in order to offer clinical and molecular diagnoses and clinical m...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2014-0346

    authors: Gomy I,Diz Mdel P

    更新日期:2016-05-13 00:00:00

  • Alternatively spliced MEFV transcript lacking exon 2 and its protein isoform pyrin-2d implies an epigenetic regulation of the gene in inflammatory cell culture models.

    abstract::The function of gene body DNA methylation in alternative splicing, and its relation to disease pathogenesis is not fully elucidated. The gene for familial Mediterranean fever (MEFV) encodes the pyrin protein and contains a 998 bp CpG island, covering the second exon, which is differentially methylated in FMF patients ...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2016-0234

    authors: Erdem GC,Erdemir S,Abaci I,Aydin AKK,Everest E,Turanli ET

    更新日期:2017-07-01 00:00:00

  • The cytotoxic and growth inhibitory effects of palladium(II) complexes on MDA-MB-435 cells.

    abstract::The antitumorigenic potential of two palladium(II) complexes, [Pd(ca(2)-o-phen)Cl(2)] - C1 and [Pd(dmba)(dppp)Cl] - C2, was evaluated, using MDA-MB-435 cells, a human breast adenocarcinoma cell-line that does not express the estrogen receptor α (ER-). Growth inhibition and induced alterations in cell-morphology were a...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/s1415-47572012005000016

    authors: Campanella NC,da Silva Demartini M,Torres C,de Almeida ET,Gouvêa CM

    更新日期:2012-01-01 00:00:00

  • Whole genome SNPs discovery in Nero Siciliano pig.

    abstract::Autochthonous pig breeds represent an important genetic reserve to be utilized mainly for the production of typical products. To explore its genetic variability, here we present for the first time whole genome sequencing data and SNPs discovered in a male domestic Nero Siciliano pig compared to the last pig reference ...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2018-0169

    authors: D'Alessandro E,Giosa D,Sapienza I,Giuffrè L,Cigliano RA,Romeo O,Zumbo A

    更新日期:2019-07-01 00:00:00

  • Isolation and multiplex genotyping of polymorphic microsatellite DNA markers in the snakehead murrel, Channa striata.

    abstract::Seven polymorphic microsatellite loci were isolated and characterized for the snakehead murrel, Channa striata (Channidae), a valuable tropical freshwater fish species. Among 25 specimens collected from Kedah state in Malaysia, the number of alleles per locus ranged from 2 to 7. Observed and expected heterozygosities ...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:

    authors: Jamsari AF,Min-Pau T,Siti-Azizah MN

    更新日期:2011-04-01 00:00:00

  • Sensitivity of RT-PCR method in samples shown to be positive for Zika virus by RT-qPCR in vector competence studies.

    abstract::Tissue samples from mosquitoes artificially infected with Zika virus and shown to be positive by RT-qPCR were reexamined by RT-PCR. Using these samples we compared the two methods employed in virus RNA detection for vector competence studies. Results demonstrated that, albeit useful, RT-PCR gave false negatives with l...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2016-0312

    authors: Paiva MHS,Guedes DRD,Leal WS,Ayres CFJ

    更新日期:2017-07-01 00:00:00

  • Electroacupuncture inhibits apoptosis in annulus fibrosis cells through suppression of the mitochondria-dependent pathway in a rat model of cervical intervertebral disc degradation.

    abstract::The purpose of this study was to investigate whether treatment with electroacupuncture (EA) inhibited mitochondria-dependent apoptosis in annulus fibrosis (AF) cells in a rat model of cervical intervertebral disc degradation induced by unbalanced dynamic and static forces. Forty Sprague-Dawley rats were used in this s...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/S1415-47572012005000046

    authors: Liao J,Ke M,Xu T,Lin L

    更新日期:2012-07-01 00:00:00

  • Allelic frequencies and statistical data obtained from 12 codis STR loci in an admixed population of the Brazilian Amazon.

    abstract::The allelic frequencies of 12 short tandem repeat loci were obtained from a sample of 307 unrelated individuals living in Macapá, a city in the northern Amazon region, Brazil. These loci are the most commonly used in forensics and paternity testing. Based on the allele frequency obtained for the population of Macapá, ...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/S1415-47572011000100007

    authors: da Costa Francez PA,Rodrigues EM,Frazão GF,Dos Reis Borges ND,Dos Santos SE

    更新日期:2011-01-01 00:00:00

  • Overall picture of expressed Heat Shock Factors in Glycine max, Lotus japonicus and Medicago truncatula.

    abstract::Heat shock (HS) leads to the activation of molecular mechanisms, known as HS-response, that prevent damage and enhance survival under stress. Plants have a flexible and specialized network of Heat Shock Factors (HSFs), which are transcription factors that induce the expression of heat shock proteins. The present work ...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/S1415-47572012000200006

    authors: Soares-Cavalcanti NM,Belarmino LC,Kido EA,Pandolfi V,Marcelino-Guimarães FC,Rodrigues FA,Pereira GA,Benko-Iseppon AM

    更新日期:2012-06-01 00:00:00

  • Comparison of the effectiveness of microsatellites and SNP panels for genetic identification, traceability and assessment of parentage in an inbred Angus herd.

    abstract::During the last decade, microsatellites (short tandem repeats or STRs) have been successfully used for animal genetic identification, traceability and paternity, although in recent year single nucleotide polymorphisms (SNPs) have been increasingly used for this purpose. An efficient SNP identification system requires ...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/S1415-47572013000200008

    authors: Fernández ME,Goszczynski DE,Lirón JP,Villegas-Castagnasso EE,Carino MH,Ripoli MV,Rogberg-Muñoz A,Posik DM,Peral-García P,Giovambattista G

    更新日期:2013-07-01 00:00:00

  • Association between human papillomavirus (HPV) DNA and micronuclei in normal cervical cytology.

    abstract::The aim of the present study was to investigate the association between HPV-DNA and micronucleus (MN) frequency in women with normal cervical cytology. A total of 158 normal cervical smears were analyzed cytologically. The HPV genome was amplified using the GP5+/bioGP6+ consensus primers. HPV-DNA of high-risk types 16...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/s1415-47572014005000010

    authors: Cassel AP,Barcellos RB,da Silva CM,de Matos Almeida SE,Rossetti ML

    更新日期:2014-06-01 00:00:00

  • bFGF promotes adipocyte differentiation in human mesenchymal stem cells derived from embryonic stem cells.

    abstract::In this work we describe the establishment of mesenchymal stem cells (MSCs) derived from embryonic stem cells (ESCs) and the role of bFGF in adipocyte differentiation. The totipotency of ESCs and MSCs was assessed by immunofluorescence staining and RT-PCR of totipotency factors. MSCs were successfully used to induce o...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/s1415-47572014000100019

    authors: Song X,Li Y,Chen X,Yin G,Huang Q,Chen Y,Xu G,Wang L

    更新日期:2014-03-01 00:00:00

  • Molecular evolution and functional divergence of alcohol dehydrogenases in animals, fungi and plants.

    abstract::Alcohol dehydrogenases belong to the large superfamily of medium-chain dehydrogenases/reductases, which occur throughout the biological world and are involved with many important metabolic routes. We considered the phylogeny of 190 ADH sequences of animals, fungi, and plants. Non-class III Caenorhabditis elegans ADHs ...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2017-0047

    authors: Thompson CE,Freitas LB,Salzano FM

    更新日期:2018-01-01 00:00:00

  • Frequency and origin of haplotypes associated with the beta-globin gene cluster in individuals with trait and sickle cell anemia in the Atlantic and Pacific coastal regions of Colombia.

    abstract::Sickle cell anemia is a genetic disease with high prevalence in people of African descent. There are five typical haplotypes associated with this disease and the haplotypes associated with the beta-globin gene cluster have been used to establish the origin of African-descendant people in America. In this work, we dete...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/S1415-47572013000400005

    authors: Fong C,Lizarralde-Iragorri MA,Rojas-Gallardo D,Barreto G

    更新日期:2013-12-01 00:00:00

  • Survey for positively selected coding regions in the genome of the hematophagous tsetse fly Glossina morsitans identifies candidate genes associated with feeding habits and embryonic development.

    abstract::Tsetse flies are responsible for the transmission of Trypanossoma sp. to vertebrate animals in Africa causing huge health issues and economic loss. The availability of the genome sequence of Glossina morsitans enabled the discovery of several genes related to medically important phenotypes and novel physiological feat...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2018-0311

    authors: Freitas L,Mesquita RD,Schrago CG

    更新日期:2020-06-10 00:00:00

  • Evidence of two lineages of the dengue vector Aedes aegypti in the Brazilian Amazon, based on mitochondrial DNA ND4 gene sequences.

    abstract::Genetic variation was estimated in ten samples populations of Aedes aegypti from the Brazilian Amazon, by using a 380 bp fragment of the mitochocondrial NADH dehydrogenase subunit 4 (ND4) gene. A total of 123 individuals were analyzed, whereby 13 haplotypes were found. Mean genetic diversity was slightly high (h = 0.6...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/S1415-47572009005000036

    authors: Lima RS Jr,Scarpassa VM

    更新日期:2009-04-01 00:00:00

  • Description of the karyotype of Rhagomys rufescens Thomas, 1886 (Rodentia, Sigmodontinae) from Southern Brazil Atlantic forest.

    abstract::Rhagomys rufescens (Rodentia: Sigmodontinae) is an endemic species of the Atlantic forest from Southern and Southeastern Brazil. Some authors consider Rhagomys as part of the tribe Thomasomyini; but its phylogenetic relationships remain unclear. Chromosomal studies on eight specimens of Rhagomys rufescens revealed a d...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/S1415-47572010005000071

    authors: Testoni AF,Althoff SL,Nascimento AP,Steiner-Souza F,Sbalqueiro IJ

    更新日期:2010-07-01 00:00:00

  • DNA sampling from eggshells and microsatellite genotyping in rare tropical birds: Case study on Brazilian Merganser.

    abstract::This study shows that sampling maternal DNA from hatched and abandoned eggshells is a viable noninvasive strategy for studying the genetics of rare or endangered tropical birds, as exemplified here by the Brazilian Merganser (Mergus octosetaceus). Eighteen microsatellites were isolated from enriched libraries and nine...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2016-0297

    authors: Maia TA,Vilaça ST,Silva LRD,Santos FR,Dantas GPM

    更新日期:2017-10-01 00:00:00

  • Xylella fastidiosa gene expression analysis by DNA microarrays.

    abstract::Xylella fastidiosa genome sequencing has generated valuable data by identifying genes acting either on metabolic pathways or in associated pathogenicity and virulence. Based on available information on these genes, new strategies for studying their expression patterns, such as microarray technology, were employed. A t...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/S1415-47572009005000038

    authors: Travensolo RF,Carareto-Alves LM,Costa MV,Lopes TJ,Carrilho E,Lemos EG

    更新日期:2009-04-01 00:00:00

  • Genetic structure of red-handed howler monkey populations in the fragmented landscape of Eastern Brazilian Amazonia.

    abstract::We genotyped 15 microsatellite loci in order to evaluate the effects of habitat fragmentation, caused by flooding of the Tucuruí reservoir, on the genetic structure of Alouatta belzebul in eastern Amazonia. The analysis included two populations sampled in 1984, representing both margins of the Tocantins river, and thr...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/s1415-47572010000400027

    authors: Bastos HB,Gonçalves EC,Ferrari SF,Silva A,Schneider MP

    更新日期:2010-10-01 00:00:00

  • Colombian Creole horse breeds: Same origin but different diversity.

    abstract::In order to understand the genetic ancestry and mitochondrial DNA (mtDNA) diversity of current Colombian horse breeds we sequenced a 364-bp fragment of the mitocondrial DNA D-loop in 116 animals belonging to five Spanish horse breeds and the Colombian Paso Fino and Colombian Creole cattle horse breeds. Among Colombian...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/S1415-47572012005000064

    authors: Jimenez LM,Mendez S,Dunner S,Cañón J,Cortés O

    更新日期:2012-12-01 00:00:00

  • Mannose-Binding Lectin 2 (MBL2) combined genotypes deficiency is associated with susceptibility for Oral Lichen Planus.

    abstract::Oral Lichen Planus (OLP) is an oral inflammatory condition, mediated by host immune system reaction, presenting basal membrane damages with inflammatory lesions in the mouth and/or skin. In this study, the role of functional polymorphisms in the MBL2 gene, encoding for Mannose-Binding Protein C (MBP-C), a member of th...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2018-0015

    authors: Polesello V,Segat L,Biasotto M,Ottaviani G,Gobbo M,Di Lenarda R,Crovella S,Zupin L

    更新日期:2019-01-01 00:00:00

  • Phylogenetic analysis, based on EPIYA repeats in the cagA gene of Indian Helicobacter pylori, and the implications of sequence variation in tyrosine phosphorylation motifs on determining the clinical outcome.

    abstract::The population of India harbors one of the world's most highly diverse gene pools, owing to the influx of successive waves of immigrants over regular periods in time. Several phylogenetic studies involving mitochondrial DNA and Y chromosomal variation have demonstrated Europeans to have been the first settlers in Indi...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/s1415-47572011005000003

    authors: Tiwari SK,Sharma V,Sharma VK,Gopi M,Saikant R,Nandan A,Bardia A,Gunisetty S,Katikala P,Habeeb MA,Khan AA,Habibullah CM

    更新日期:2011-04-01 00:00:00

  • The catalase gene family in cucumber: genome-wide identification and organization.

    abstract::Catalase (CAT) is a common antioxidant enzyme in almost all living organisms. Currently, detailed reports on cucumber (Cucumis sativus L.) CAT (CsCAT) genes and tissue expression profiling are limited. In the present study, four candidate CsCAT genes were identified in cucumber. Phylogenetic analysis indicated that Cs...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2015-0192

    authors: Hu L,Yang Y,Jiang L,Liu S

    更新日期:2016-07-01 00:00:00

  • Genome-wide association study of drought-related resistance traits in Aegilops tauschii.

    abstract::The D-genome progenitor of wheat (Triticum aestivum), Aegilops tauschii, possesses numerous genes for resistance to abiotic stresses, including drought. Therefore, information on the genetic architecture of A. tauschii can aid the development of drought-resistant wheat varieties. Here, we evaluated 13 traits in 373 A....

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2015-0232

    authors: Qin P,Lin Y,Hu Y,Liu K,Mao S,Li Z,Wang J,Liu Y,Wei Y,Zheng Y

    更新日期:2016-07-01 00:00:00

  • Can plant DNA barcoding be implemented in species-rich tropical regions? A perspective from São Paulo State, Brazil.

    abstract::DNA barcoding helps to identify species, especially when identification is based on parts of organisms or life stages such as seeds, pollen, wood, roots or juveniles. However, the implementation of this approach strongly depends on the existence of complete reference libraries of DNA sequences. If such a library is in...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2017-0282

    authors: Lima RAF,Oliveira AA,Colletta GD,Flores TB,Coelho RLG,Dias P,Frey GP,Iribar A,Rodrigues RR,Souza VC,Chave J

    更新日期:2018-07-01 00:00:00

  • MicroRNA-296-5p is differentially expressed in individuals with and without HIV-1 infection.

    abstract::MicroRNAs are considered as potential biomarkers, agents, or therapeutic targets; few studies have addressed the expression of miRNAs in treatment-naïve patients infected with HIV-1. The aim of this study was to assess plasma relative circulating miRNA expression profiles in treatment-naïve Mexican patients with HIV/A...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2020-0017

    authors: Cárdenas-Bedoya J,Marquez-Pedroza J,Morán-Moguel MC,Escoto-Delgadillo M,Vázquez-Valls E,González-Enríquez GV,Pérez-Ríos AM,Torres-Mendoza BM

    更新日期:2020-06-22 00:00:00

  • Gender-dependent association of HSD11B1 single nucleotide polymorphisms with glucose and HDL-C levels.

    abstract::In this study, we investigated the influence of two SNPs (rs846910 and rs12086634) of the HSD11B1 gene that encodes 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1), the enzyme that catalyzes the conversion of cortisol to cortisone, on variables associated with obesity and metabolic syndrome in 215 individuals of bot...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/s1415-47572014000400003

    authors: Turek LV,Leite N,Rodrigues Souza RL,Lima JK,Milano GE,Timossi Lda S,Osiecki AC,Osiecki R,Alle LF

    更新日期:2014-09-01 00:00:00

  • A walk on the wild side: Oryza species as source for rice abiotic stress tolerance.

    abstract::Oryza sativa, the common cultivated rice, is one of the most important crops for human consumption, but production is increasingly threatened by abiotic stresses. Although many efforts have resulted in breeding rice cultivars that are relatively tolerant to their local environments, climate changes and population incr...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2016-0093

    authors: Menguer PK,Sperotto RA,Ricachenevsky FK

    更新日期:2017-01-01 00:00:00

  • The genomes of three Bradyrhizobium sp. isolated from root nodules of Lupinus albescens grown in extremely poor soils display important genes for resistance to environmental stress.

    abstract::Lupinus albescens is a resistant cover plant that establishes symbiotic relationships with bacteria belonging to the Bradyrhizobium genus. This symbiosis helps the development of these plants in adverse environmental conditions, such as the ones found in arenized areas of Southern Brazil. This work studied three Brady...

    journal_title:Genetics and molecular biology

    pub_type: 杂志文章

    doi:10.1590/1678-4685-GMB-2017-0098

    authors: Granada CE,Vargas LK,Sant'Anna FH,Balsanelli E,Baura VA,Oliveira Pedrosa F,Souza EM,Falcon T,Passaglia LMP

    更新日期:2018-04-01 00:00:00