Abstract:
:In the present study, water buffalo MHC (Bubu)-DRB cDNA was cloned and characterized. The 1022 base long-amplified cDNA product encompassed a single open reading frame of 801 bases that coded for 266 amino acids. The Bubu-DRB sequence showed maximum homology with the BoLA-DRB3*0101 allele of cattle. A total of seven amino acid residues were found to be unique for the Bubu-DRB sequence. The majority of amino acid substitutions was observed in the β(1) domain. Residues associated with important functions were mostly conserved. Water buffalo DRB was phylogenetically closer to goat DRB*A.
journal_name
Genet Mol Bioljournal_title
Genetics and molecular biologyauthors
Naskar S,Deb SM,Niranjan SK,Kumar S,Sharma D,Sakaram D,Sharma Adoi
10.1590/s1415-47572012005000013subject
Has Abstractpub_date
2012-01-01 00:00:00pages
95-8issue
1eissn
1415-4757issn
1678-4685journal_volume
35pub_type
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