Abstract:
:Making decisions based on choice-outcome history is a crucial, adaptive ability in life. However, the neural circuit mechanisms underlying history-dependent decision-making are poorly understood. In particular, history-related signals have been found in many brain areas during various decision-making tasks, but the causal involvement of these signals in guiding behavior is unclear. Here we addressed this issue utilizing behavioral modeling, two-photon calcium imaging, and optogenetic inactivation in mice. We report that a subset of neurons in the posterior parietal cortex (PPC) closely reflect the choice-outcome history and history-dependent decision biases, and PPC inactivation diminishes the history dependency of choice. Specifically, many PPC neurons show history- and bias-tuning during the inter-trial intervals (ITI), and history dependency of choice is affected by PPC inactivation during ITI and not during trial. These results indicate that PPC is a critical region mediating the subjective use of history in biasing action selection.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Hwang EJ,Dahlen JE,Mukundan M,Komiyama Tdoi
10.1038/s41467-017-01356-zsubject
Has Abstractpub_date
2017-11-01 00:00:00pages
1242issue
1issn
2041-1723pii
10.1038/s41467-017-01356-zjournal_volume
8pub_type
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