History-based action selection bias in posterior parietal cortex.

Abstract:

:Making decisions based on choice-outcome history is a crucial, adaptive ability in life. However, the neural circuit mechanisms underlying history-dependent decision-making are poorly understood. In particular, history-related signals have been found in many brain areas during various decision-making tasks, but the causal involvement of these signals in guiding behavior is unclear. Here we addressed this issue utilizing behavioral modeling, two-photon calcium imaging, and optogenetic inactivation in mice. We report that a subset of neurons in the posterior parietal cortex (PPC) closely reflect the choice-outcome history and history-dependent decision biases, and PPC inactivation diminishes the history dependency of choice. Specifically, many PPC neurons show history- and bias-tuning during the inter-trial intervals (ITI), and history dependency of choice is affected by PPC inactivation during ITI and not during trial. These results indicate that PPC is a critical region mediating the subjective use of history in biasing action selection.

journal_name

Nat Commun

journal_title

Nature communications

authors

Hwang EJ,Dahlen JE,Mukundan M,Komiyama T

doi

10.1038/s41467-017-01356-z

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1242

issue

1

issn

2041-1723

pii

10.1038/s41467-017-01356-z

journal_volume

8

pub_type

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