Abstract:
:Ghrelin, a hormone produced primarily by the stomach, has been associated with motivational processes that include reward-seeking behaviors. In male laboratory mice, elevation of ghrelin levels enhances some aspects of sexual motivation and behavior, whereas in other experiments with male mice, rats, and other species, ghrelin treatment or food deprivation decreases sexual motivation and/or behavior. The present tested the hypothesis that stimulation of ghrelin receptors in different brain regions have opposite effects on male sexual motivation and behavior. To do this we examined appetitive and consummatory sex behaviors of male rats with a truncated ghrelin receptor (FHH-GHSRm1/Mcwi), and that of their WT (FHH) littermates. We also examined the effects of ghrelin or the ghrelin antagonist D-Lys-GHRP6 delivered into the VTA or the MPOA on appetitive and consummatory sex behaviors in male Long Evans rats. Results demonstrate that rats with a truncated ghrelin receptor, or rats that are food deprived, show deficits in anticipatory sex. Furthermore, although ghrelin does not further stimulate sex anticipation in rats when infused into the VTA, intra-VTA infusions of D-Lys-GHRP6 into the VTA further decreases in sex anticipation in food deprived rats. In contrast, ghrelin delivery into the mPOA decreased sex anticipation compared to saline or D-Lys-GHRP6 infused rats. Overall, these data suggest that ghrelin receptor signalling is important for full expression of appetitive sex behaviors. Within the VTA, ghrelin may act to enhance sex motivation, while acting on the mPOA to decrease sex motivation and promote foraging.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Hyland L,Rosenbaum S,Edwards A,Palacios D,Graham MD,Pfaus JG,Woodside B,Abizaid Adoi
10.1016/j.yhbeh.2017.10.012subject
Has Abstractpub_date
2018-01-01 00:00:00pages
56-66eissn
0018-506Xissn
1095-6867pii
S0018-506X(17)30270-2journal_volume
97pub_type
杂志文章abstract::Aggressive encounters are accompanied by a release of stress hormone, and this corticosterone (CORT) secretion could influence aggressive behavior in subsequent encounters. We investigated the modulating effects of CORT on aggressive behavior in the context of a 5-day social experience in male green anole lizards. In ...
journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
pub_type: 杂志文章,随机对照试验
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journal_title:Hormones and behavior
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abstract::Responses to vibrotactile stimuli were examined in men as a function of chronic exposure to either exogenous or endogenous androgens. Psychophysical techniques were used to evaluate thresholds to stimulus detection and perceived stimulus intensities in response to mild vibration applied to either the finger or the pen...
journal_title:Hormones and behavior
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journal_title:Hormones and behavior
pub_type: 杂志文章,评审
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.2000.1572
更新日期:2000-05-01 00:00:00
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2013.05.008
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2016.07.005
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journal_title:Hormones and behavior
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doi:10.1016/j.yhbeh.2009.09.018
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2006.06.009
更新日期:2007-01-01 00:00:00
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
pub_type: 临床试验,杂志文章
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journal_title:Hormones and behavior
pub_type: 杂志文章,评审
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更新日期:1994-12-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2009.06.003
更新日期:2010-01-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2008.01.014
更新日期:2008-05-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 历史文章,杂志文章,评审
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
pub_type: 杂志文章
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更新日期:1983-06-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
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更新日期:1988-03-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2006.06.006
更新日期:2006-09-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2009.08.007
更新日期:2009-10-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2004.07.001
更新日期:2004-12-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1997.1421
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journal_title:Hormones and behavior
pub_type: 杂志文章
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/s0018-506x(03)00119-3
更新日期:2003-08-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00