Abstract:
:This article is part of a Special Issue "Estradiol and cognition". In addition to their well-studied and crucial effects on brain development and aging, an increasing number of investigations across vertebrate species indicate that estrogens like 17β-estradiol (E2) have pronounced and rapid effects on cognitive function. The incidence and regulation of the E2-synthesizing enzyme aromatase at the synapse in regions of the brain responsible for learning, memory, social communication and other complex cognitive processes suggest that local E2 production and action affect the acute and chronic activity of individual neurons and circuits. Songbirds in particular are excellent models for the study of this "synaptocrine" hormone provision given that aromatase is abundantly expressed in neuronal soma, dendrites, and at the synapse across many brain regions in both sexes. Additionally, songbirds readily acquire and recall memories in laboratory settings, and their stereotyped behaviors may be manipulated and measured with relative ease. This leads to a rather unparalleled advantage in the use of these animals in studies of the role of neural aromatization in cognition. In this review we describe the results of a number of experiments in songbird species with a focus on the influence of synaptic E2 provision on two cognitive processes: auditory discrimination reliant on the caudomedial nidopallium (NCM), a telencephalic region likely homologous to the auditory cortex in mammals, and spatial memory dependent on the hippocampus. Data from these studies are providing evidence that the local and acute provision of E2 modulates the hormonal, electrical, and cognitive outputs of the vertebrate brain and aids in memory acquisition, retention, and perhaps the confluence of memory systems.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Bailey DJ,Saldanha CJdoi
10.1016/j.yhbeh.2015.06.007subject
Has Abstractpub_date
2015-08-01 00:00:00pages
116-24eissn
0018-506Xissn
1095-6867pii
S0018-506X(15)00116-6journal_volume
74pub_type
杂志文章,评审abstract::Female hormonal contraceptive use has been associated with a variety of physical and psychological side effects. Women who use hormonal contraceptives report more intense affective responses to partner infidelity and greater overall sexual jealousy than women not using hormonal contraceptives. Recently, researchers ha...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2011.10.011
更新日期:2012-01-01 00:00:00
abstract::This work tested the hypothesis that gonadal steroid receptor activation was necessary for the restoration of several sociosexual behaviors (such as copulatory behavior, partner preference, 50-kHz vocalizations, and scent marking) in testosterone-treated gonadectomized male rats. Gonadal steroid receptors were blocked...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1998.1445
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abstract::Developmental plasticity of HPA and fear responses in rats has been proposed to be mediated by environment-dependent variation in active maternal care. Here, we review this maternal mediation hypothesis based on the postnatal manipulation literature and on our own recent research in rats. We show that developmental pl...
journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2006.06.015
更新日期:2006-12-01 00:00:00
abstract::Syrian hamsters are photoperiodic and become sexually quiescent when exposed to short "winter-like" photoperiods. In short photoperiods, male hamsters display significantly higher levels of aggression than males housed in long photoperiods. Arginine-vasopressin (AVP) within the anterior hypothalamus (AH) has been repo...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2004.04.006
更新日期:2004-11-01 00:00:00
abstract::As a continuation of the study carried out by Svare more than 15 years ago (Horm. Behav. 22 (1988), 139) and to determine the tendencies of the evolution of behavioral endocrinology since then, our aim was to extend his work until 2000, assuming that the journal Hormones and Behavior would be representative of the fie...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/s0018-506x(03)00008-4
更新日期:2003-03-01 00:00:00
abstract::This article is part of a Special Issue "Puberty and Adolescence". The pubertal period is a time of change in an animal's response to stress, and it is a second period of sexual differentiation of the brain. Recently, it was discovered that particular stressors during the prolonged pubertal period of female mice resul...
journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2013.01.015
更新日期:2013-07-01 00:00:00
abstract::The impact of blood leakage due to microinjury to the oral cavity on the measurement of salivary hormones was examined. Saliva samples were collected before, immediately after, and then every 15 min for 1 h following vigorous tooth brushing. Blood in saliva was quantified by visual inspection of discoloration, Hemasti...
journal_title:Hormones and behavior
pub_type: 临床试验,杂志文章
doi:10.1016/j.yhbeh.2004.01.006
更新日期:2004-06-01 00:00:00
abstract::Male wild house mice, selected for short (SAL) and long (LAL) attack latency, show distinctly different behavioral strategies in coping with environmental challenges. In this study, we tested the hypothesis that this difference in coping style is associated with a differential stress responsiveness of the hypothalamic...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/s0018-506x(02)00013-2
更新日期:2003-01-01 00:00:00
abstract::The first issue of Hormones and Behavior was published 50 years ago in 1969, a time when most of the techniques we currently use in Behavioral Endocrinology were not available. Researchers have during the last 5 decades developed techniques that allow measuring hormones in small volumes of biological samples, identify...
journal_title:Hormones and behavior
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.yhbeh.2020.104682
更新日期:2020-02-01 00:00:00
abstract::Dehydration impairs cognitive performance in humans and rodents, although studies in animal models are limited. Estrogens have both protective effects on fluid regulation and improve performance in certain cognitive tasks. We, therefore, tested whether sex and gonadal hormones influence object recognition memory durin...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2019.06.011
更新日期:2019-08-01 00:00:00
abstract::Research was undertaken to study the role of central angiotensin in the modulation of male sexual behavior, testing the effect of angiotensin II (Ang II) injections into the medial amygdaloid nucleus (MeA). The sexual behavior of adult male Wistar rats was evaluated, 15 min after bilateral intra-amygdaloid microinject...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.2002.1771
更新日期:2002-05-01 00:00:00
abstract::It has been hypothesized that in avian social groups subordinate individuals should maintain more energy reserves than dominants, as an insurance against increased perceived risk of starvation. Subordinates might also have elevated baseline corticosterone levels because corticosterone is known to facilitate fattening ...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/s0018-506x(03)00119-3
更新日期:2003-08-01 00:00:00
abstract::Recognition memory and anxiety were examined in nulliparous (NP: 0 litters) and multiparous (MP: 5-6 litters) middle-aged female rats (12 months old) to assess possible enduring effects of multiparity at least 3 months after the last litter was weaned. MP females performed significantly better than NP females on the n...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2007.08.011
更新日期:2008-06-01 00:00:00
abstract::There is growing evidence from preclinical studies for an involvement of orexins (ORX) in the regulation of stress, affectivity and addictive behavior. The aim of our study was to gather corresponding clinical data and to elucidate the relationships between alcohol withdrawal stress, ORX plasma concentration and psych...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2011.08.017
更新日期:2011-11-01 00:00:00
abstract::The evolutionary processes that result in reliable links between male signals and fighting capacity have received a great deal of attention, but the proximate mechanisms underlying such connections remain understudied. We studied a large sample of male green anole lizards (Anolis carolinensis) to determine whether tes...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2007.05.014
更新日期:2007-09-01 00:00:00
abstract::In many species, females are more sexually attractive to males near ovulation. Some evidence suggests a similar pattern in humans, but methodological limitations prohibit firm conclusions at present, and information on physiological mechanisms underlying any such pattern is lacking. In 202 normally-cycling women, we e...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2012.11.007
更新日期:2013-01-01 00:00:00
abstract::Exposure of female rats to estradiol during the perinatal period has profound effects on GABAergic neurotransmission that are crucial to establish sexually dimorphic brain characteristics. We previously showed that neonatal β-estradiol 3-benzoate (EB) treatment decreases brain concentrations of the neurosteroid allopr...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2016.10.005
更新日期:2017-01-01 00:00:00
abstract::Two experiments examined the properties of vaginal, facial, salivary, and urinary odors from female house mice to elicit ultrasonic vocalizations from male mice. Experiment 1 demonstrated that facial and salivary secretions from hypophysectomized females were significantly less effective in eliciting ultrasonic vocali...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/0018-506x(86)90029-2
更新日期:1986-03-01 00:00:00
abstract::Environmental stress conditions are important factors in human health and should be considered in the development of appropriate health policies, since they have been associated with psychological disorders and even with death. A link between stress and changes in 3alpha,5alpha-reduced neurosteroids has been reported....
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2009.07.001
更新日期:2009-09-01 00:00:00
abstract::Systemic administration of ovine prolactin (PRL) has been previously reported to stimulate parental feeding behavior toward 7-day-old foster squabs by nonbreeding ring doves with previous breeding experience. The first of the present experiments reexamined this claim in experienced, nonbreeding birds given test squabs...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/0018-506x(91)90012-7
更新日期:1991-09-01 00:00:00
abstract::The brain of the adult teleost fish exhibits intense neurogenic activity and an outstanding capability for brain repair. Remarkably, the brain estrogen-synthesizing enzyme, aromatase B, is strongly expressed, particularly in adult fishes, in radial glial cells, which act as progenitors. Using zebrafish, we tested the ...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2012.04.003
更新日期:2013-02-01 00:00:00
abstract::In most male birds that exhibit paternal care, extending the spring testosterone (T) peak throughout the breeding season reduces nestling provisioning. However, in some species, this trade-off between high T and expression of paternal care is absent. For example, during some or all of the nestling period, T did not af...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2004.10.004
更新日期:2005-02-01 00:00:00
abstract::Recent studies have reported that oxytocin ameliorates behavioral abnormalities in both animal models and individuals with autism spectrum disorders (ASD). However, the mechanisms underlying the ameliorating effects of oxytocin remain unclear. In this study, we examined the effects of intranasal oxytocin on impairment...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2017.09.013
更新日期:2017-11-01 00:00:00
abstract::In this study we tested the hypothesis that in a passerine bird (great tit, Parus major) individuals differing for coping strategies differ in the magnitude of the adrenocortical response to social stress as well. Furthermore, we aimed at characterizing daily rhythms in corticosteroid release before and after social s...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/s0018-506x(03)00065-5
更新日期:2003-05-01 00:00:00
abstract::Aggressive interactions in Anolis carolinensis result in increased circulating levels of epinephrine (Epi) and norepinephrine (NE) and conspicuous color changes. This activation of the adrenergic component of an acute stress response is externally represented by the darkening of the postorbital eyespot of A. carolinen...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1994.1003
更新日期:1994-03-01 00:00:00
abstract::Testosterone (T) is often referred to as the "male hormone," but it can influence aggression, parental behavior, and immune function in both males and females. By experimentally relating hormone-induced changes in phenotype to fitness, it is possible to ask whether existing phenotypes perform better or worse than alte...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2013.03.005
更新日期:2013-05-01 00:00:00
abstract::We examined effects of a wide range of doses of three man-made estrogenic chemicals during fetal life on neurobehavioral changes during early postnatal life in mice. Pregnant mice were fed a 4-log range of o,p'DDT, methoxychlor (MXC), and the drug diethystilbestrol (DES) from gestation days 11 to 17. Offspring were ex...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.2001.1697
更新日期:2001-09-01 00:00:00
abstract::This article is part of a Special Issue "Energy Balance". Energy homeostasis is achieved through neuroendocrine and metabolic control of energy intake, storage, and expenditure. Traditionally, these controls have been studied in an unrealistic and narrow context. The appetite for food, for example, is most often assum...
journal_title:Hormones and behavior
pub_type: 社论
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abstract::Depression is one of the most common mental disorders and a primary cause of disability. To better treat patients suffering this illness, elucidation of the underlying psychopathological and neurobiological mechanisms is urgently needed. Based on the above-mentioned evidence, we sought to investigate the effects of ne...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2015.05.018
更新日期:2015-07-01 00:00:00
abstract::Most nonhuman primate research on risk factors underlying vulnerability to stress has focused on early psychosocial experiences in various species of macaques. To test for genetic and experiential effects on emotional vulnerability in randomly bred squirrel monkeys, here we combined a paternal half-sibling analysis wi...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1999.1547
更新日期:1999-12-01 00:00:00