Enduring influence of pubertal stressors on behavioral response to hormones in female mice.

Abstract:

:This article is part of a Special Issue "Puberty and Adolescence". The pubertal period is a time of change in an animal's response to stress, and it is a second period of sexual differentiation of the brain. Recently, it was discovered that particular stressors during the prolonged pubertal period of female mice result in enduring changes in behavioral responsiveness of the brain to estradiol and progesterone. Depending on the behavior, pubertal immune challenge or shipping from suppliers may decrease, eliminate, or even reverse the effects of estradiol. Pubertal immune challenge results in changes in the number of estrogen receptor-immunoreactive cells in key brain areas suggesting a cellular mechanism for this remodeling of the brain's response to hormones. A hypothesis is put forward that predicts that particular adverse experiences in girls may cause long-term alterations in the brain's response to estradiol and/or progesterone via activation of the immune system. This could lead to mood disorders or altered response to any behavior influenced by estradiol in humans.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Blaustein JD,Ismail N

doi

10.1016/j.yhbeh.2013.01.015

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

390-8

issue

2

eissn

0018-506X

issn

1095-6867

pii

S0018-506X(13)00035-4

journal_volume

64

pub_type

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