Abstract:
:Endocrine disruptors, chemicals that disturb the actions of endogenous hormones, have been implicated in birth defects associated with hormone-dependent development. Phytoestrogens are a class of endocrine disruptors found in plants. In the current study we examined the effects of exposure at various perinatal time periods to genistein, a soy phytoestrogen, on reproductive development and learning in male rats. Dams were fed genistein-containing (5 mg/kg feed) food during both gestation and lactation, during gestation only, during lactation only, or during neither period. Measures of reproductive development and body mass were taken in the male offspring during postnatal development, and learning and memory performance was assessed in adulthood. Genistein exposure via the maternal diet decreased body mass in the male offspring of dams fed genistein during both gestation and lactation, during lactation only, but not during gestation only. Genistein decreased anogenital distance when exposure was during both gestation and lactation, but there was no effect when exposure was limited to one of these time periods. Similarly, spatial learning in the Morris water maze was impaired in male rats exposed to genistein during both gestation and lactation, but not in rats exposed during only one of these time periods. There was no effect of genistein on cued or contextual fear conditioning. In summary, the data indicate that exposure to genistein through the maternal diet significantly impacts growth in male offspring if exposure is during lactation. The effects of genistein on reproductive development and spatial learning required exposure throughout the pre- and postnatal periods.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Ball ER,Caniglia MK,Wilcox JL,Overton KA,Burr MJ,Wolfe BD,Sanders BJ,Wisniewski AB,Wrenn CCdoi
10.1016/j.yhbeh.2009.12.013subject
Has Abstractpub_date
2010-03-01 00:00:00pages
313-22issue
3eissn
0018-506Xissn
1095-6867pii
S0018-506X(09)00284-0journal_volume
57pub_type
杂志文章abstract::Male and female hamsters differ in the stimulus control of the ultrasounds they produce during courtship and mating. In particular, untreated males show greater increases in ultrasound rate after exposure to stimulus females than after contact with other males. Conversely, estrous females are more responsive to stimul...
journal_title:Hormones and behavior
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doi:10.1016/0018-506x(87)90027-4
更新日期:1987-03-01 00:00:00
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
pub_type: 临床试验,杂志文章
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journal_title:Hormones and behavior
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doi:10.1016/s0018-506x(02)00012-0
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2011.05.002
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2005.03.004
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journal_title:Hormones and behavior
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.yhbeh.2014.06.015
更新日期:2014-08-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2014.02.005
更新日期:2014-06-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.2000.1638
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2014.04.015
更新日期:2014-07-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2013.05.012
更新日期:2013-08-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2018.10.002
更新日期:2018-11-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2013.03.005
更新日期:2013-05-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2006.06.028
更新日期:2006-11-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2004.10.004
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journal_title:Hormones and behavior
pub_type: 临床试验,杂志文章
doi:10.1016/j.yhbeh.2005.03.010
更新日期:2005-09-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/0018-506x(88)90064-5
更新日期:1988-06-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2005.05.016
更新日期:2006-02-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2015.06.007
更新日期:2015-08-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2008.12.004
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2011.04.003
更新日期:2011-07-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1995.1002
更新日期:1995-03-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章,meta分析,评审
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