Early life stress and cortisol: A meta-analysis.

Abstract:

:Given the high prevalence of early life stress (ELS) and the potential physiological dysregulation such experiences can lead to, this meta-analysis tested the relationship between ELS and cortisol. Search terms related to ELS and cortisol were entered in to PsycINFO and PubMed. Effect sizes were extracted for four outcomes variables: cortisol awakening response (CAR), baseline cortisol (cortisol at one time point), non-stressed cortisol over time (cortisol captured at two or more time points), and cortisol reactivity to an acute stressor. The articles were additionally coded for potential confounding variables, population-related, ELS-related and cortisol-related moderators. There was no significant relationship between ELS and the CAR (g=0.19, p=0.268), ELS and baseline cortisol (g=-0.072, p=0.328), ELS and non-stressed cortisol over time (g=0.09, p=0.292) or ELS and cortisol reactivity (g=-0.089, p=0.363). However, there was a significant amount of heterogeneity amongst relationships. Within the ELS-CAR relationship, in those who had experienced ELS that was sexually, physically or emotionally abusive, the CAR was heightened. Within the ELS-Baseline relationship, if blood samples were collected the ELS was associated with a blunting effect of cortisol. The non-significant main effects challenge the commonly held belief in the literature that ELS affects cortisol later in life. However, the high degree of heterogeneity uncovered by this analysis and significant moderators suggest that the literature may benefit from consistent operationalizations of ELS and standardized methods of how cortisol is measured.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Fogelman N,Canli T

doi

10.1016/j.yhbeh.2017.12.014

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

63-76

eissn

0018-506X

issn

1095-6867

pii

S0018-506X(17)30349-5

journal_volume

98

pub_type

杂志文章,meta分析,评审
  • Behavioral and adrenocortical responses to mate separation and reunion in the zebra finch.

    abstract::The adaptive value of social affiliation has been well established. It is unclear, however, what endogenous mechanisms may mediate affiliative behavior. The Australian zebra finch (Taeniopygia guttata) breeds colonially and adults maintain lifelong pair bonds that may be disrupted in the wild due to high mortality rat...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/s0018-506x(02)00012-0

    authors: Remage-Healey L,Adkins-Regan E,Romero LM

    更新日期:2003-01-01 00:00:00

  • Neuroendocrine correlates of behavioral polymorphism in white-throated sparrows.

    abstract::Interspecific differences in the neuropeptide systems of the lateral septum (LS) often parallel differences in social behavior. In rodents, some closely related species that differ in aggressive behavior also differ according to the level of vasopressin (VP) innervation of the LS. In songbirds, the neuropeptides vasot...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2005.03.004

    authors: Maney DL,Erwin KL,Goode CT

    更新日期:2005-08-01 00:00:00

  • Implication of galanin gene rs948854 polymorphism in depressive symptoms in adolescents.

    abstract::Genetic, social, and environmental conditions contribute to the development of depression, but the pathophysiological mechanisms are still unclear. Data accumulated in recent years provide significant evidence for a direct role of galanin (GAL). This study aimed to investigate the relation between SNPs in the galanine...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2017.10.001

    authors: da Conceição Machado F,de Souza LV,Rangel M,Jara ZP,do Carmo Franco M

    更新日期:2018-01-01 00:00:00

  • Interaction effects of corticosterone and experience on aggressive behavior in the green anole lizard.

    abstract::Aggressive encounters are accompanied by a release of stress hormone, and this corticosterone (CORT) secretion could influence aggressive behavior in subsequent encounters. We investigated the modulating effects of CORT on aggressive behavior in the context of a 5-day social experience in male green anole lizards. In ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/s0018-506x(03)00139-9

    authors: Yang EJ,Wilczynski W

    更新日期:2003-09-01 00:00:00

  • In vivo aromatization of [3H]testosterone in high and low mating lines of Japanese quail.

    abstract::Japanese quail selected bidirectionally for adult mating frequency were utilized to study in vivo aromatization of testosterone (T) in relation to masculine copulatory behavior. Functionally castrated high (HM) and low mating (LM) line quail were injected with 75 microCi of [3H]T. One hour after the injection, all rad...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/0018-506x(83)90031-4

    authors: Cohen-Parsons M,Van Krey HP,Siegel PB

    更新日期:1983-09-01 00:00:00

  • A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer' disease.

    abstract::Previous studies have shown that melatonin is implicated in modulating learning and memory processing. Melatonin also exerts neuroprotective activities against Aβ-induced injury in vitro and in vivo. Neu-P11 (piromelatine, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-4-oxo-4H-pyran-2-carboxamide) is a novel melatonin (MT1/MT2...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2013.04.009

    authors: He P,Ouyang X,Zhou S,Yin W,Tang C,Laudon M,Tian S

    更新日期:2013-06-01 00:00:00

  • A hormonal basis for sex differences in the self-grooming of rats.

    abstract::The self-grooming behavior of prepubescent male and female rats is described. Sex differences were observed in components of grooming addressed to the genitals, but not in other aspects of grooming. A hormonal basis for the sex difference was examined in two experiments. When females were injected with testosterone pr...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/0018-506x(86)90014-0

    authors: Moore CL

    更新日期:1986-06-01 00:00:00

  • Estrogen implants in the medial preoptic area stimulate maternal behavior in male rats.

    abstract::The present study investigated whether the medial preoptic area (MPOA) mediates estrogen stimulation of maternal behavior in the male as it does in the female. Previous studies have shown that lesions of the medial preoptic area prevent sensitization of maternal behavior in male rats and that in gonadectomized, hormon...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.1997.1430

    authors: Rosenblatt JS,Ceus K

    更新日期:1998-02-01 00:00:00

  • Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring.

    abstract::It is known that the early environment affects the mental development of rodent and human offspring. However, it is not known specifically whether a postpartum depressive state influences the depressive state in offspring. Using learned helplessness (LH) in rats as an animal model of depression, we examined the influe...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2009.03.016

    authors: Kurata A,Morinobu S,Fuchikami M,Yamamoto S,Yamawaki S

    更新日期:2009-06-01 00:00:00

  • Preferences for masculinity in male bodies change across the menstrual cycle.

    abstract::In human females cyclic shifts in preference have been documented for odour and physical and behavioral male traits. Women prefer the smell of dominant males, more masculine male faces and men behaving more dominantly when at peak fertility than at other times in their menstrual cycle. Here we examine variation in pre...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2007.03.006

    authors: Little AC,Jones BC,Burriss RP

    更新日期:2007-05-01 00:00:00

  • Mating call phonotaxis in female American toad: lesions of anterior preoptic nucleus.

    abstract::Lesions of the preoptic area and immediately adjacent septal area were made in female American toads, Bufo americanus. The ability to show mating call phonotaxis (MCP) was then tested for. The intensity of MCP was found to decrease as the degree of damage to the anterior tip of the anterior preoptic nucleus (APON) inc...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/0018-506x(89)90070-6

    authors: Schmidt RS

    更新日期:1989-03-01 00:00:00

  • Cryptic sexual dimorphism in spatial memory and hippocampal oxytocin receptors in prairie voles (Microtus ochrogaster).

    abstract::Sex differences are well documented and are conventionally associated with intense sex-specific selection. For example, spatial memory is frequently better in males, presumably due to males' tendency to navigate large spaces to find mates. Alternatively, monogamy (in which sex-specific selection is relatively relaxed)...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2017.08.003

    authors: Rice MA,Hobbs LE,Wallace KJ,Ophir AG

    更新日期:2017-09-01 00:00:00

  • Hippocampal anatomy and water maze performance are affected by neonatal cryoanesthesia in rats of both sexes.

    abstract::There is recent evidence that cryoanesthesia, commonly used during neonatal hormone manipulations (e.g., gonadectomy), has deleterious effects on the morphology of the splenium of the corpus callosum and primary visual cortex in adult rats of both sexes. (Nuñez and Juraska, 1998; Nuñez, Kim, and Juraska, 1998). In the...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.2000.1572

    authors: Nuñez JL,Koss WA,Juraska JM

    更新日期:2000-05-01 00:00:00

  • Evidence for cell proliferation in the sheep brain and its down-regulation by parturition and interactions with the young.

    abstract::Production of new neurons continues throughout life in the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus and is influenced by both endocrine and social factors. In sheep parturition is associated with the establishment of a selective bond with the young based on an olfactory learning. The pos...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2010.07.006

    authors: Brus M,Meurisse M,Franceschini I,Keller M,Lévy F

    更新日期:2010-11-01 00:00:00

  • Postnatal experiences and genetic effects on squirrel monkey social affinities and emotional distress.

    abstract::Most nonhuman primate research on risk factors underlying vulnerability to stress has focused on early psychosocial experiences in various species of macaques. To test for genetic and experiential effects on emotional vulnerability in randomly bred squirrel monkeys, here we combined a paternal half-sibling analysis wi...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.1999.1547

    authors: Lyons DM,Martel FL,Levine S,Risch NJ,Schatzberg AF

    更新日期:1999-12-01 00:00:00

  • Corticosterone and time-activity budget: an experiment with Black-legged kittiwakes.

    abstract::In vertebrates, the well established increase in plasma corticosterone in response to food shortage is thought to mediate adjustments of foraging behavior and energy allocation to environmental conditions. However, investigating the functional role of corticosterone is often constrained by the difficulty to track time...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2007.07.003

    authors: Angelier F,Clément-Chastel C,Gabrielsen GW,Chastel O

    更新日期:2007-11-01 00:00:00

  • Tectal CRFR1 receptors modulate food intake and feeding behavior in the South African clawed frog Xenopus laevis.

    abstract::The optic tectum and superior colliculus rapidly inhibit food intake when a visual threat is present. Previous work indicates that CRF, acting on CRFR1 receptors, may play a role in tectal inhibition of feeding behavior and food intake. Here we test the hypothesis that tectal CRFR1 receptors modulate food intake and f...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2018.07.013

    authors: Prater CM,Harris BN,Carr JA

    更新日期:2018-09-01 00:00:00

  • Enduring influence of pubertal stressors on behavioral response to hormones in female mice.

    abstract::This article is part of a Special Issue "Puberty and Adolescence". The pubertal period is a time of change in an animal's response to stress, and it is a second period of sexual differentiation of the brain. Recently, it was discovered that particular stressors during the prolonged pubertal period of female mice resul...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.yhbeh.2013.01.015

    authors: Blaustein JD,Ismail N

    更新日期:2013-07-01 00:00:00

  • The importance of neural aromatization in the acquisition, recall, and integration of song and spatial memories in passerines.

    abstract::This article is part of a Special Issue "Estradiol and cognition". In addition to their well-studied and crucial effects on brain development and aging, an increasing number of investigations across vertebrate species indicate that estrogens like 17β-estradiol (E2) have pronounced and rapid effects on cognitive functi...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.yhbeh.2015.06.007

    authors: Bailey DJ,Saldanha CJ

    更新日期:2015-08-01 00:00:00

  • A phylogenetically controlled test of hypotheses for behavioral insensitivity to testosterone in birds.

    abstract::In most male birds that exhibit paternal care, extending the spring testosterone (T) peak throughout the breeding season reduces nestling provisioning. However, in some species, this trade-off between high T and expression of paternal care is absent. For example, during some or all of the nestling period, T did not af...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2004.10.004

    authors: Lynn SE,Walker BG,Wingfield JC

    更新日期:2005-02-01 00:00:00

  • Localized and discrete changes in neuropeptide (LHRH and TRH) and neurotransmitter (NE and DA) concentrations within the olfactory bulbs of male mice as a function of social interaction.

    abstract::Individually housed male mice were exposed to either an intact male or an ovariectomized female mouse for 1 min and decapitated at 5, 15, or 60 min to examine the hypothesis whether discrete changes in olfactory bulb neuropeptide (LHRH and TRH) and neurotransmitter (NE and DA) concentrations would occur following onse...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/0018-506x(83)90001-6

    authors: Dluzen DE,Ramirez VD

    更新日期:1983-06-01 00:00:00

  • Behavioral profiles and stress-induced corticosteroid secretion in male Wistar rats subjected to short and prolonged periods of maternal separation.

    abstract::Early life experiences are important for the development of neurobiobehavioral mechanisms and subsequent establishment of mental functions. In experimental animals, early life experiences can be studied using the maternal separation model. Maternal separation has been described to induce neurobiological changes and th...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2006.06.016

    authors: Roman E,Gustafsson L,Berg M,Nylander I

    更新日期:2006-12-01 00:00:00

  • Effects of multiparity on recognition memory, monoaminergic neurotransmitters, and brain-derived neurotrophic factor (BDNF).

    abstract::Recognition memory and anxiety were examined in nulliparous (NP: 0 litters) and multiparous (MP: 5-6 litters) middle-aged female rats (12 months old) to assess possible enduring effects of multiparity at least 3 months after the last litter was weaned. MP females performed significantly better than NP females on the n...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2007.08.011

    authors: Macbeth AH,Scharfman HE,Maclusky NJ,Gautreaux C,Luine VN

    更新日期:2008-06-01 00:00:00

  • Hormonal correlates of breeding status, nest construction, and parental care in multiple-brooded northern mockingbirds, Mimus polyglottos.

    abstract::Blood samples were taken from free-living male and female mockingbirds to determine correlations between plasma steroids and breeding behavior. Plasma levels of testosterone (T), estradiol (E2), progesterone (P), and corticosterone (B) were assessed during pre-breeding courtship, while males built nests, while females...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.1995.1002

    authors: Logan CA,Wingfield JC

    更新日期:1995-03-01 00:00:00

  • Somatic correlates of adrenergic activity during aggression in the lizard, Anolis carolinensis.

    abstract::Aggressive interactions in Anolis carolinensis result in increased circulating levels of epinephrine (Epi) and norepinephrine (NE) and conspicuous color changes. This activation of the adrenergic component of an acute stress response is externally represented by the darkening of the postorbital eyespot of A. carolinen...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.1994.1003

    authors: Summers CH,Greenberg N

    更新日期:1994-03-01 00:00:00

  • Photoperiodic regulation of the orexigenic effects of ghrelin in Siberian hamsters.

    abstract::Animals living in temperate climates with predictable seasonal changes in food availability may use seasonal information to engage different metabolic strategies. Siberian hamsters decrease costs of thermoregulation during winter by reducing food intake and body mass in response to decreasing or short-day lengths (SD)...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2010.06.009

    authors: Bradley SP,Pattullo LM,Patel PN,Prendergast BJ

    更新日期:2010-09-01 00:00:00

  • The effects of estradiol and progesterone on pain sensitivity and brain opioid receptors in ovariectomized rats.

    abstract::Previous studies in our laboratory have shown that estradiol and progesterone affect beta-endorphin and Met-enkephalin levels in specific brain regions and that these effects are diurnally controlled. The present investigation was conducted to evaluate the effects of estradiol and progesterone on pain latency and brai...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.1996.0029

    authors: Gordon FT,Soliman MR

    更新日期:1996-09-01 00:00:00

  • Fraternal birth order and the maternal immune hypothesis of male homosexuality.

    abstract::In men, sexual orientation correlates with an individual's number of older brothers, each additional older brother increasing the odds of homosexuality by approximately 33%. It has been hypothesized that this fraternal birth order effect reflects the progressive immunization of some mothers to Y-linked minor histocomp...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审

    doi:10.1006/hbeh.2001.1681

    authors: Blanchard R

    更新日期:2001-09-01 00:00:00

  • The effects of oral micronized progesterone on smoked cocaine self-administration in women.

    abstract::There are currently no FDA-approved pharmacotherapies for cocaine abuse. Converging preclinical and clinical evidence indicates that progesterone may have potential as a treatment for cocaine-abusing women, who represent a growing portion of cocaine users. We have previously shown that oral progesterone reduced the po...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.yhbeh.2010.12.009

    authors: Reed SC,Evans SM,Bedi G,Rubin E,Foltin RW

    更新日期:2011-02-01 00:00:00

  • First evidence on the role of palmitoylethanolamide in energy homeostasis in fish.

    abstract::The objective of this study was to investigate the role of palmitoylethanolamide (PEA) in the regulation of energy homeostasis in goldfish (Carassius auratus). We examined the effects of acute or chronic intraperitoneal treatment with PEA (20 μg·g-1 body weight) on parameters related to food intake and its regulatory ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2019.104609

    authors: Gómez-Boronat M,Isorna E,Conde-Sieira M,Delgado MJ,Soengas JL,de Pedro N

    更新日期:2020-01-01 00:00:00