Abstract：
:A growing body of evidence demonstrates that estrogen and corticosterone (CORT) impact on cognition and emotion. On the one hand, ovarian hormones may have beneficial effects on several neurophysiological processes, including memory. On the other hand, chronic exposure to stressful conditions has negative effects on brain structures related to learning and memory. In the present study, we used the plus-maze discriminative avoidance task (PMDAT) to evaluate the influence of endogenous variations of sex hormones and exposure to different types of prolonged stressors on learning, memory, anxiety-like behavior and locomotion. Female Wistar rats were submitted to seven consecutive days of restraint stress (4 h/day), overcrowding (18 h/day) or social isolation (18 h/day) and tested in different phases of the estrous cycle. The main results showed that: (1) neither stress conditions nor estrous cycle modified PMDAT acquisition; (2) restraint stress and social isolation induced memory impairments; (3) this impairment was observed particularly in females in metestrus/diestrus; (4) stressed females in estrus displayed less risk assessment behavior, suggesting reduced anxiety-like behavior; (5) restraint stress and social isolation, but not overcrowding, elevated corticosterone levels. Taken together, our findings suggest that the phase of the estrous cycle is an important modulatory factor of the cognitive processing disrupted by stress in female rats. Negative effects were observed in metestrus/diestrus, indicating that the peak of sex hormones may protect females against stress-induced memory impairment.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
do Nascimento EB,Dierschnabel AL,de Macêdo Medeiros A,Suchecki D,Silva RH,Ribeiro AMdoi
10.1016/j.yhbeh.2019.104563subject
Has Abstractpub_date
2019-09-01 00:00:00pages
104563eissn
0018-506Xissn
1095-6867pii
S0018-506X(18)30402-1journal_volume
115pub_type
杂志文章abstract：:Aggressive encounters are accompanied by a release of stress hormone, and this corticosterone (CORT) secretion could influence aggressive behavior in subsequent encounters. We investigated the modulating effects of CORT on aggressive behavior in the context of a 5-day social experience in male green anole lizards. In ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/s0018-506x(03)00139-9
更新日期：2003-09-01 00:00:00
abstract：:In rodents, early exposure to adult male is well known to induce an early puberty in females (Vandenbergh effect). This phenomenon has been less studied in other mammals. In goats, despite our extensive knowledge about the "male-effect" phenomenon in adults (i.e. ovulation induced by the introduction of the male durin...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2018.10.004
更新日期：2018-11-01 00:00:00
abstract：:The effects of marijuana's major psychoactive cannabinoid, ∆9-tetrahydrocannibinol (∆9-THC), were examined on memory in female rats by training subjects to respond under a repeated acquisition and delayed-performance procedure. During this task, subjects acquired a different 4-response sequence each session, which was...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2020.104883
更新日期：2021-01-01 00:00:00
abstract：:The present study investigated whether the circadian oscillators controlling rhythms in activity behavior and melatonin secretion shared similar functional relationship with the external environment. We simultaneously measured the effects of varying illuminations on rhythms of movement and melatonin levels in Indian w...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2012.01.015
更新日期：2012-04-01 00:00:00
abstract：:Recent studies have reported that oxytocin ameliorates behavioral abnormalities in both animal models and individuals with autism spectrum disorders (ASD). However, the mechanisms underlying the ameliorating effects of oxytocin remain unclear. In this study, we examined the effects of intranasal oxytocin on impairment...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2017.09.013
更新日期：2017-11-01 00:00:00
abstract：:Stress during pregnancy and the postpartum can influence the well-being of both the mother and her offspring. Prolonged elevated levels of glucocorticoids are associated with depression and we developed an animal model of postpartum depression/stress based on high levels of corticosterone (CORT) during the postpartum....
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2010.07.012
更新日期：2010-11-01 00:00:00
abstract：:Lordosis responses by estrous hamsters were triggered by brief manual stimulation. Lordosis durations then were timed, as manual stimulation was discontinued, and subjects were exposed to tape-recordings of conspecific vocalizations reproduced at intensities of 0-60 dB SPL. Relative to the durations observed in the pr...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(87)90010-9
更新日期：1987-12-01 00:00:00
abstract：:Transient shifts in testosterone occur during competition and are thought to positively influence dominance behavior aimed at enhancing social status. However, individual differences in testosterone reactivity to status contests have not been well-studied in relation to real-time expressions of competitive behavior am...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.104665
更新日期：2020-07-01 00:00:00
abstract：:Glucocorticoids have wide-ranging effects on animals' behaviour, but many of these effects remain poorly understood because numerous confounding factors have often been neglected in previous studies. Here, we present data from a 2-year study of 7 groups of wild Verreaux's sifakas (Propithecus verreauxi), in which we e...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2020.104760
更新日期：2020-08-01 00:00:00
abstract：:The sources of cues necessary for elicitation of androgen surges and sexual behavior in male golden hamsters (Mesocricetus auratus) were investigated. Circulating androgen levels were measured in males after interactions with other males or several types of estrous females: intact females, vaginectomized females, or v...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(92)90048-z
更新日期：1992-06-01 00:00:00
abstract：:A meta-analysis of the literature shows that in adult male songbirds, brain mass, telencephalon volume and n. rotundus (a thalamic visual nucleus) volume increase from the nonbreeding season (low testosterone) to the breeding season (higher testosterone). These effects can at least partially be mimicked by photoperiod...
journal_title：Hormones and behavior
pub_type： 杂志文章,meta分析
doi：10.1006/hbeh.2001.1748
更新日期：2002-03-01 00:00:00
abstract：:3,4-methylenedioxymethamphetamine (MDMA) is a substituted phenethylamine that is widely abused as the street drug "ecstasy". Racemic MDMA (S,R(+/-)-MDMA) and its stereoisomers elicit complex spectrums of psychobiological, neurochemical, and hormonal effects. In this regard, recent findings demonstrated that S,R(+/-)-M...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.10.012
更新日期：2012-02-01 00:00:00
abstract：:The effects and the mediation of the action of the proenkephalin derivative Met(5)-enkephalin-Arg(6)-Phe(7) (MERF) on the hypothalamo-pituitary-adrenal (HPA) system and open-field behavior were investigated in mice. Intracerebroventricular injection of the heptapeptide increased square crossing, rearing, and plasma co...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/s0018-506x(03)00004-7
更新日期：2003-02-01 00:00:00
abstract：:It is known that the early environment affects the mental development of rodent and human offspring. However, it is not known specifically whether a postpartum depressive state influences the depressive state in offspring. Using learned helplessness (LH) in rats as an animal model of depression, we examined the influe...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2009.03.016
更新日期：2009-06-01 00:00:00
abstract：:Previous research in the zebra finch, a socially monogamous pair-bonding species, suggests that the preference for opposite-sex partners may arise in part through the organizing actions of sex steroids. To further investigate this process, zebra finch eggs were injected with 20 microg fadrozole, a potent estrogen synt...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.2000.1627
更新日期：2001-02-01 00:00:00
abstract：:Many seasonally breeding vertebrate species have an associated reproductive pattern: mating behavior, gonadal activity, and peak circulating androgen levels occur simultaneously. In these species, androgens influence the expression of male mating behavior. Other species have a dissociated reproductive pattern: mating ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2007.02.004
更新日期：2007-04-01 00:00:00
abstract：:Dehydration impairs cognitive performance in humans and rodents, although studies in animal models are limited. Estrogens have both protective effects on fluid regulation and improve performance in certain cognitive tasks. We, therefore, tested whether sex and gonadal hormones influence object recognition memory durin...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.06.011
更新日期：2019-08-01 00:00:00
abstract：:Most work investigating modulation of testosterone (T) levels in birds has focused on northern temperate and Arctic species, and to a lesser degree, tropical species. Studies exploring modulation of T in birds in temperate regions of the Southern Hemisphere are lacking. Here we explore patterns of T secretion across t...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.05.002
更新日期：2011-07-01 00:00:00
abstract：:Previous studies of changes in women's behavior during the menstrual cycle have offered insight into the motivations underpinning women's preferences for social cues associated with possible direct benefits (e.g., investment, low risk of infection) and indirect benefits (e.g., offspring viability). Here we sought to e...
journal_title：Hormones and behavior
pub_type： 临床试验,杂志文章
doi：10.1016/j.yhbeh.2005.03.010
更新日期：2005-09-01 00:00:00
abstract：:Sex steroids were initially defined by their actions shaping sexually dimorphic behavioral patterns. More recently scientists have begun exploring the role of steroids in determining sex differences in behavioral plasticity. We investigated the role of androgens in potentiating circadian, pharmacological, and socially...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2009.05.005
更新日期：2009-08-01 00:00:00
abstract：:Findings from previous studies of hormone-mediated behavior in women suggest that raised progesterone level increases the probability of behaviors that will reduce the likelihood of disruption to fetal development during pregnancy (e.g. increased avoidance of sources of contagion). Here, we tested women's (N=52) sensi...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2006.10.002
更新日期：2007-02-01 00:00:00
abstract：:The hormone oxytocin (OT) is released both centrally and peripherally during and after mating. Although research in humans suggests a central role in sexuality, the most reliable findings to date involve peripheral activation. This review will discuss these results and will particularly focus on understanding the most...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2011.11.001
更新日期：2012-03-01 00:00:00
abstract：:When ovariectomized/adrenalectomized female rats, injected with subthreshold doses of estradiol are given copulatory stimulation by a male rat at half hour intervals, the level of lordosis gradually increases over the course of a few hours. We tested the hypothesis that paracopulatory behaviors (behaviors that occur r...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2008.12.008
更新日期：2009-03-01 00:00:00
abstract：:Women's ovulation is perceivable with different senses. Already subtle face shape differences are enough to trigger men's preference for the ovulatory female. The aim of the present study is to investigate if men's testosterone level can be linked to their preference for the ovulatory female. Thirty-nine heterosexual ...
journal_title：Hormones and behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.yhbeh.2014.06.015
更新日期：2014-08-01 00:00:00
abstract：:After proposing the organizational hypothesis from research in prenatally androgenized guinea pigs (Phoenix, C.H., Goy, R.W., Gerall, A.A., Young, W.C., 1959. Organizational action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 65, 36...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2009.03.015
更新日期：2009-05-01 00:00:00
abstract：:A total of 54 ovariectomized female guinea pigs were divided into three groups and tested six times at 2-week intervals for their responsiveness to exogenous ovarian hormones (3 days of 4 micrograms/kg estradiol benzoate plus 1 day of 0.4 mg/kg progesterone) or control injections (0.2 ml oil vehicle). Two weeks after ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(85)90005-4
更新日期：1985-03-01 00:00:00
abstract：:The vertebrate hippocampus (HP) plays a critical role in the organization of memory. Estrogens alter synaptic morphology and function in the mammalian HP and may potentiate memory performance. Previous studies suggest that the songbird HP itself is a site of significant aromatase expression, intimating that local estr...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1998.1447
更新日期：1998-10-01 00:00:00
abstract：:Based on a wide variety of data, it is now clear that birds and teleost (bony) fish possess a core "social behavior network" within the basal forebrain and midbrain that is homologous to the social behavior network of mammals. The nodes of this network are reciprocally connected, contain receptors for sex steroid horm...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2005.02.003
更新日期：2005-06-01 00:00:00
abstract：:In a previous study we found that mother rats show more drinking responses than virgins in the punished drinking paradigm, an animal model for anxiety. The present investigation was carried out to determine the possible mechanisms underlying this naturally occurring anticonflict effect. In Experiment 1, we investigate...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(90)90004-h
更新日期：1990-06-01 00:00:00
abstract：:It has been suggested that male achievement in sports and athletics is correlated with a putative measure of prenatal testosterone the 2nd to 4th digit ratio (2D:4D). It is not known whether this association also extends to females, or whether the association results from an effect of testosterone on behavior (such as...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2005.11.006
更新日期：2006-04-01 00:00:00
