Abstract：
:After proposing the organizational hypothesis from research in prenatally androgenized guinea pigs (Phoenix, C.H., Goy, R.W., Gerall, A.A., Young, W.C., 1959. Organizational action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 65, 369-382.), the same authors almost immediately extended the hypothesis to a nonhuman primate model, the rhesus monkey. Studies over the last 50 years have verified that prenatal androgens have permanent effects in rhesus monkeys on the neural circuits that underlie sexually dimorphic behaviors. These behaviors include both sexual and social behaviors, all of which are also influenced by social experience. Many juvenile behaviors such as play, mounting, and vocal behaviors are masculinized and/or defeminized, and aspects of adult sexual behavior are both masculinized (e.g. approaches, sex contacts, and mounts) and defeminized (e.g. sexual solicits). Different behavioral endpoints have different periods of maximal susceptibility to the organizing actions of prenatal androgens. Aromatization is not important, as both testosterone and dihydrotestosterone are equally effective in rhesus monkeys. Although the full story of the effects of prenatal androgens on sexual and social behaviors in the rhesus monkey has not yet completely unfolded, much progress has been made. Amazingly, a large number of the inferences drawn from the original 1959 study have proved applicable to this nonhuman primate model.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Thornton J,Zehr JL,Loose MDdoi
10.1016/j.yhbeh.2009.03.015subject
Has Abstractpub_date
2009-05-01 00:00:00pages
633-45issue
5eissn
0018-506Xissn
1095-6867pii
S0018-506X(09)00065-8journal_volume
55pub_type
杂志文章,评审abstract：:A number of studies have shown that chronic stress can negatively impact both physiology and behavior in a variety of organisms. What has yet to be extensively explored is whether these changes permanently alter an animal's functioning, or if they can be reversed. In this study, we used wild-caught house sparrows (Pas...
journal_title：Hormones and behavior
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journal_title：Hormones and behavior
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1996.0049
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journal_title：Hormones and behavior
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2007.03.029
更新日期：2007-08-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2014.03.017
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journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2010.04.005
更新日期：2011-03-01 00:00:00
abstract：:Behavioral studies of an XY gonadal dysgenetic chacma baboon under estradiol benzoate treatment were carried out. The dysgenetic individual and two ovariectomized conspecific control females were given a total of three testing series. The dysgenetic individual showed progressive success in her sexual interactions with...
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pub_type： 杂志文章
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更新日期：1984-06-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2016.05.021
更新日期：2016-08-01 00:00:00
abstract：:Perinatal treatment of female rats with androgen decreases the nuclear volume of the anteroventral periventricular nucleus of the preoptic area (AVPvN-POA). In order to examine the effect of androgen on neurogenesis, bromodeoxyuridine (BrdU) was given once on Day 15 of gestation (= E15) to pregnant rats that also rece...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1994.1027
更新日期：1994-12-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.07.013
更新日期：2011-09-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.05.002
更新日期：2011-07-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2013.08.006
更新日期：2013-09-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2013.05.008
更新日期：2013-06-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2014.03.005
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2007.07.001
更新日期：2007-11-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2008.02.015
更新日期：2008-05-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2016.12.015
更新日期：2017-03-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.2001.1661
更新日期：2001-08-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2017.03.004
更新日期：2017-05-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2013.10.011
更新日期：2014-01-01 00:00:00
abstract：:Testosterone is thought to be positively associated with "mating effort", or the initiation and establishment of sexual relationships (Wingfield et al., 1990). Yet, because testosterone is negatively associated with nurturance (van Anders et al., 2011), high levels of testosterone may be incompatible with relationship...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2014.03.003
更新日期：2014-04-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.2002.1824
更新日期：2002-11-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2013.02.007
更新日期：2013-04-01 00:00:00
abstract：:Chronic stress in various forms increases the risk for cognitive dysfunction, dementia and Alzheimer's disease. While the pathogenesis behind these findings is unknown, growing evidence suggests that chronic increase in neurosteroid levels, such as allopregnanolone, is part of the mechanism. We treated wild-type C57BL...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2015.10.010
更新日期：2016-02-01 00:00:00
abstract：:Women are 60% more likely to suffer from an anxiety disorder than men. One hypothesis for this difference may be that females exhibit increased rates of fear generalization. Females generalize fear to a neutral context faster than males, a process driven, in part, by estrogens. In the current study, ovariectomized adu...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2014.06.017
更新日期：2014-07-01 00:00:00
