Abstract：
:Pregnancy and the postpartum period are times of profound behavioral change including alterations in cognitive function. This has been most often studied using hippocampal-dependent tasks assessing spatial learning and memory. However, less is known about the cognitive effects of motherhood for tasks that rely on areas other than the hippocampus. We have previously shown that postpartum females perform better on the extradimensional phase of an attentional set shifting task, a measure of cognitive flexibility which is dependent on the medial prefrontal cortex (mPFC). The present experiments aimed to extend this work by examining the importance of postpartum stage as well as offspring and parity in driving improved mPFC cognitive function during motherhood. We also examined whether the neuropeptide oxytocin, which plays a role in regulating numerous maternal functions, mediates enhanced cognitive flexibility during motherhood. Our results demonstrate that compared to virgin females, cognitive flexibility is enhanced in mothers regardless of postpartum stage and is not affected by parity since both first (primiparous) and second (biparous) time mothers showed the enhancement. Moreover, we found that improved cognitive flexibility in mothers requires the presence of offspring, as removal of the pups abolished the cognitive enhancement in postpartum females. Lastly, using an oxytocin receptor antagonist, we demonstrate that oxytocin signaling in the mPFC is necessary for the beneficial effects of motherhood on cognitive flexibility. Together, these data provide insights into the temporal, experiential and hormonal factors which regulate mPFC-dependent cognitive function during the postpartum period.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Albin-Brooks C,Nealer C,Sabihi S,Haim A,Leuner Bdoi
10.1016/j.yhbeh.2016.12.015subject
Has Abstractpub_date
2017-03-01 00:00:00pages
130-136eissn
0018-506Xissn
1095-6867pii
S0018-506X(16)30325-7journal_volume
89pub_type
杂志文章abstract：:This article is part of a Special Issue "Chemosignals and Reproduction". Chemical cues were probably the first cues ever used to communicate and are still ubiquitous among living organisms. Birds have long been considered an exception: it was believed that birds were anosmic and relied on their acute visual and acoust...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
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journal_title：Hormones and behavior
pub_type： 杂志文章
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journal_title：Hormones and behavior
pub_type： 杂志文章,评审
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2004.10.004
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journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2015.06.007
更新日期：2015-08-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2008.12.008
更新日期：2009-03-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2007.07.001
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2009.04.006
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journal_title：Hormones and behavior
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doi：10.1016/j.yhbeh.2010.06.009
更新日期：2010-09-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.2001.1702
更新日期：2001-11-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.yhbeh.2008.03.013
更新日期：2008-08-01 00:00:00
abstract：:Behavioral studies of an XY gonadal dysgenetic chacma baboon under estradiol benzoate treatment were carried out. The dysgenetic individual and two ovariectomized conspecific control females were given a total of three testing series. The dysgenetic individual showed progressive success in her sexual interactions with...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(84)90042-4
更新日期：1984-06-01 00:00:00
abstract：:A total of 54 ovariectomized female guinea pigs were divided into three groups and tested six times at 2-week intervals for their responsiveness to exogenous ovarian hormones (3 days of 4 micrograms/kg estradiol benzoate plus 1 day of 0.4 mg/kg progesterone) or control injections (0.2 ml oil vehicle). Two weeks after ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(85)90005-4
更新日期：1985-03-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.104577
更新日期：2019-11-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 临床试验,杂志文章
doi：10.1016/j.yhbeh.2004.01.006
更新日期：2004-06-01 00:00:00
abstract：:Japanese quail selected bidirectionally for adult mating frequency were utilized to study in vivo aromatization of testosterone (T) in relation to masculine copulatory behavior. Functionally castrated high (HM) and low mating (LM) line quail were injected with 75 microCi of [3H]T. One hour after the injection, all rad...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(83)90031-4
更新日期：1983-09-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.104665
更新日期：2020-07-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2013.10.011
更新日期：2014-01-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2018.07.013
更新日期：2018-09-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章,收录出版
doi：10.1016/j.yhbeh.2018.12.014
更新日期：2019-02-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2008.09.011
更新日期：2009-01-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2008.02.015
更新日期：2008-05-01 00:00:00
abstract：:We administered the synthetic estrogen, diethylstilbestrol (DES), or the antiestrogen, tamoxifen, to pregnant guinea pigs and observed the consequences for sexual differentiation of their female offspring. Hormones were administered during the period when treatment of fetuses with testosterone influences the developme...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(87)90024-9
更新日期：1987-09-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2008.08.009
更新日期：2009-01-01 00:00:00
abstract：:This study examined the effects of long-term estrogen treatment (sc 17 beta-estradiol minipellets) on learning in C57BL/6J female and male mice using a position discrimination task in the T-maze and a win-stay task (1/8 arms baited) in the radial arm maze (RAM). In addition, hippocampal monoamines and ChAT activity we...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.2001.1738
更新日期：2002-02-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2010.07.006
更新日期：2010-11-01 00:00:00
abstract：:A growing body of research indicates that testosterone influences spatial cognition in male rats; however, the overwhelming majority of studies have been conducted on tasks motivated by either food deprivation or water escape. The hippocampus-dependent version of the Y-maze task, which characterizes spatial recognitio...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2013.02.007
更新日期：2013-04-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2012.08.009
更新日期：2012-11-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1006/hbeh.2001.1681
更新日期：2001-09-01 00:00:00
abstract：:Recent reports support higher than expected rates of binge alcohol consumption among women and girls. Unfortunately, few studies have assessed the mechanisms underlying this pattern of intake in females. Studies in males suggest that alcohol concentrations relevant to the beginning stages of binge intoxication may sel...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2017.07.015
更新日期：2017-09-01 00:00:00
