Abstract：
:Androgen receptors are expressed in many different neuronal populations in the central nervous system where they often act as transcription factors in the cell nucleus. However, recent studies have detected androgen receptor immunoreactivity in neuronal and glial processes of the adult rat neocortex, hippocampal formation, and amygdala as well as in the telencephalon of eastern fence and green anole lizards. This review discusses previously published findings on extranuclear androgen receptors, as well as new experimental results that begin to establish a possible functional role for androgen receptors in axons within cortical regions. Electron microscopic studies have revealed that androgen receptor immunoreactive processes in the rat brain correspond to axons, dendrites and glial processes. New results show that lesions of the dorsal CA1 region by local administration of ibotenic acid reduce the density of androgen receptor immunoreactive axons in the cerebral cortex and the amygdala, suggesting that these axons may originate in the hippocampus. Androgen receptor immunoreactivity in axons is also decreased by the intracerebroventricular administration of colchicine, suggesting that androgen receptor protein is transported from the perikaryon to the axons by fast axonal transport. Androgen receptors in axons located in the cerebral cortex and amygdala and originating in the hippocampus may play an important role in the rapid behavioral effects of androgens.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Sarkey S,Azcoitia I,Garcia-Segura LM,Garcia-Ovejero D,DonCarlos LLdoi
10.1016/j.yhbeh.2008.02.015subject
Has Abstractpub_date
2008-05-01 00:00:00pages
753-64issue
5eissn
0018-506Xissn
1095-6867pii
S0018-506X(08)00056-1journal_volume
53pub_type
杂志文章,评审abstract：:When rats are mated in a traditional mating chamber (with one male and one female) in which the male dictates the pace of the copulatory sequence, males develop a reward state as evaluated by conditioned place preference (CPP). In this mating situation no reward state is induced in females. However, when female rats a...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.2001.1712
更新日期：2001-12-01 00:00:00
abstract：:Bacteria have had a fundamental impact on vertebrate evolution not only by affecting the evolution of the immune system, but also generating complex interactions with behavior and physiology. Advances in molecular techniques have started to reveal the intricate ways in which bacteria and vertebrates have coevolved. He...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2016.12.003
更新日期：2017-02-01 00:00:00
abstract：:Ghrelin, a hormone produced primarily by the stomach, has been associated with motivational processes that include reward-seeking behaviors. In male laboratory mice, elevation of ghrelin levels enhances some aspects of sexual motivation and behavior, whereas in other experiments with male mice, rats, and other species...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2017.10.012
更新日期：2018-01-01 00:00:00
abstract：:Glucocorticoids are thought to mediate the disruption of parental behavior in response to acute and chronic stress. Previous research supports their role in chronic stress; however, no study has experimentally tested the effects of acute glucocorticoid elevation on paternal behavior. We tested the prediction that acut...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.09.001
更新日期：2011-11-01 00:00:00
abstract：:Patients with thyroid dysfunction (31 hypothyroid, 32 subclinical hypothyroidism, 34 hyperthyroid, and 30 subclinical hyperthyroidism) and 37 euthyroid control subjects were recruited and performed the attention network test (ANT), which can simultaneously examine the alertness, orientation and execution control of th...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2020.104714
更新日期：2020-05-01 00:00:00
abstract：:Three experiments were conducted to test whether testicular hormones secreted during puberty masculinize and defeminize the expression of adult reproductive behavior. Experiment 1 tested the hypothesis that gonadal hormones during puberty masculinize behavioral responses to testosterone (T) in adulthood. Male hamsters...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2003.12.007
更新日期：2004-04-01 00:00:00
abstract：:Previous studies have documented the ability of neural grafts to stimulate the recovery of lordosis from neurochemical deficits. However, it was unclear if grafts also could reverse deficits in lordosis caused by lesions at critical points in the neural circuit controlling this response. To address this question, fema...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1997.1421
更新日期：1997-12-01 00:00:00
abstract：:This article is part of a Special Issue "Puberty and Adolescence". This paper examines consistency of effects of pubertal timing (going through puberty earlier, later or at the same time one's cohort of peers) on the development of psychopathology during adolescence as well as the persistence of effects into adulthood...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2013.04.003
更新日期：2013-07-01 00:00:00
abstract：:Male Syrian hamsters (Mesocricetus auratus) administered anabolic/androgenic steroids during adolescent development display increased aggression and decreased anxious behavior during the adolescent exposure period. Upon withdrawal from anabolic/androgenic steroids, this neurobehavioral relationship shifts and hamsters...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.104650
更新日期：2020-03-01 00:00:00
abstract：:Most nonhuman primate research on risk factors underlying vulnerability to stress has focused on early psychosocial experiences in various species of macaques. To test for genetic and experiential effects on emotional vulnerability in randomly bred squirrel monkeys, here we combined a paternal half-sibling analysis wi...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1999.1547
更新日期：1999-12-01 00:00:00
abstract：:A contribution to a special issue on Hormones and Human Competition. A stress perspective is used to illuminate how competitive defeat and victory shape biology and behavior. We report a field study examining how change in cortisol following perceived defeat (vs. victory) in a competition-in this case, a dog agility c...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2016.12.005
更新日期：2017-06-01 00:00:00
abstract：:Previous studies in our laboratory have shown that estradiol and progesterone affect beta-endorphin and Met-enkephalin levels in specific brain regions and that these effects are diurnally controlled. The present investigation was conducted to evaluate the effects of estradiol and progesterone on pain latency and brai...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1996.0029
更新日期：1996-09-01 00:00:00
abstract：:Studies examining the roles of estrogens and progestins on spatial cognition have been highly contradictory. To determine if the hormonal environment of pregnancy affects spatial cognition, pregnant (n = 7) and virgin (n = 7) Hooded Long-Evans rats were tested in a Morris water maze throughout the 3 weeks of pregnancy...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2005.08.002
更新日期：2006-03-01 00:00:00
abstract：:Selective breeding of rats exhibiting differences in novelty-induced locomotion revealed that this trait predicts several differences in emotional behavior. Bred High Responders (bHRs) show exaggerated novelty-induced locomotion, aggression, and psychostimulant self-administration, compared to bred Low Responders (bLR...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2010.02.004
更新日期：2010-04-01 00:00:00
abstract：:Sex hormones are significant regulators of stress reactivity, however, little is known about how genetic variation in hormone receptors contributes to this process. Here we report interactions between biological sex and repeat polymorphisms in genes encoding sex hormone receptors, and their effects on salivary cortiso...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2018.10.002
更新日期：2018-11-01 00:00:00
abstract：:Interspecific differences in the neuropeptide systems of the lateral septum (LS) often parallel differences in social behavior. In rodents, some closely related species that differ in aggressive behavior also differ according to the level of vasopressin (VP) innervation of the LS. In songbirds, the neuropeptides vasot...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2005.03.004
更新日期：2005-08-01 00:00:00
abstract：:Aggressive interactions in Anolis carolinensis result in increased circulating levels of epinephrine (Epi) and norepinephrine (NE) and conspicuous color changes. This activation of the adrenergic component of an acute stress response is externally represented by the darkening of the postorbital eyespot of A. carolinen...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1994.1003
更新日期：1994-03-01 00:00:00
abstract：:This article is part of a Special Issue "Puberty and Adolescence". The pubertal period is a time of change in an animal's response to stress, and it is a second period of sexual differentiation of the brain. Recently, it was discovered that particular stressors during the prolonged pubertal period of female mice resul...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2013.01.015
更新日期：2013-07-01 00:00:00
abstract：:Conspicuous sexual swellings in the females of some primate species have been a focus of scientific interest since Darwin first wrote about them in 1871. To understand these visual signals, research focused on exaggerated sexual swellings of Old World primates. However, some primate species develop much smaller sexual...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2006.10.008
更新日期：2007-02-01 00:00:00
abstract：:Environmental perturbations increase adrenal activity in several vertebrates. Increases in corticosterone may serve as a proximate trigger whereby organisms can rapidly adapt their behavior to survive environmental fluctuations. In food-caching songbirds, inclement weather may present the need to alter caching and/or ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.2000.1571
更新日期：2000-03-01 00:00:00
abstract：:The gonadal hormone testosterone (T) regulates aggression across a wide range of vertebrate species. Recent evidence suggests that the adrenal prohormone dehydroepiandrosterone (DHEA) may also play an important role in regulating aggression. DHEA can be converted into active sex steroids, such as T and estradiol (E(2)...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2009.07.004
更新日期：2009-10-01 00:00:00
abstract：:The aim of this study was to examine changes in rat emotional behavior and determine differences in the expression of GABA-A receptor alpha-2 subunits in brain structures of low- (LR) and high-anxiety (HR) rats after the repeated corticosterone administration. The animals were divided into LR and HR groups based on th...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2013.10.011
更新日期：2014-01-01 00:00:00
abstract：:In estradiol-primed nonreceptive ovariectomized rats, activation of G protein-coupled estrogen receptor 1 (GPER) in the arcuate nucleus of the hypothalamus (ARH) rapidly facilitates sexual receptivity (lordosis). Estradiol priming activates ARH β-endorphin (β-END) neurons that then activate medial preoptic (MPN) μ-opi...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.04.004
更新日期：2019-06-01 00:00:00
abstract：:Sex differences are well documented and are conventionally associated with intense sex-specific selection. For example, spatial memory is frequently better in males, presumably due to males' tendency to navigate large spaces to find mates. Alternatively, monogamy (in which sex-specific selection is relatively relaxed)...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2017.08.003
更新日期：2017-09-01 00:00:00
abstract：:In a previous study we found that mother rats show more drinking responses than virgins in the punished drinking paradigm, an animal model for anxiety. The present investigation was carried out to determine the possible mechanisms underlying this naturally occurring anticonflict effect. In Experiment 1, we investigate...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(90)90004-h
更新日期：1990-06-01 00:00:00
abstract：:Ovarian steroid hormones, estradiol and progesterone, regulate cellular functions in the central nervous system, resulting in the alterations in physiology and reproductive behavior. One means by which steroid hormones exert their neural effects on reproductive behavior is via their intracellular receptors functioning...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1006/hbeh.2001.1687
更新日期：2001-09-01 00:00:00
abstract：:Melatonin has been suggested to affect human emotion, but conflicting evidence exists. Therefore, we tested the effect of a single dose of a 4 mg prolonged release formulation of melatonin on a biologically based model of emotional processing. Affective modulation of acoustic white noise startle (103 dB) by emotional ...
journal_title：Hormones and behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.yhbeh.2008.03.013
更新日期：2008-08-01 00:00:00
abstract：:Social interactions are important factors determining and regulating individual behaviors. Testosterone has been related to agonistic interactions, while glucocorticoids have been related to social stress, especially during interactions of dominance. We compared testosterone and cortisol concentrations in male degus (...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2004.11.010
更新日期：2005-03-01 00:00:00
abstract：:We administered the synthetic estrogen, diethylstilbestrol (DES), or the antiestrogen, tamoxifen, to pregnant guinea pigs and observed the consequences for sexual differentiation of their female offspring. Hormones were administered during the period when treatment of fetuses with testosterone influences the developme...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(87)90024-9
更新日期：1987-09-01 00:00:00
abstract：:This article is part of a Special Issue "Chemosignals and Reproduction". Chemical cues were probably the first cues ever used to communicate and are still ubiquitous among living organisms. Birds have long been considered an exception: it was believed that birds were anosmic and relied on their acute visual and acoust...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2014.06.001
更新日期：2015-02-01 00:00:00
