Effects of pregnancy on spatial cognition in female Hooded Long-Evans rats.

Abstract:

:Studies examining the roles of estrogens and progestins on spatial cognition have been highly contradictory. To determine if the hormonal environment of pregnancy affects spatial cognition, pregnant (n = 7) and virgin (n = 7) Hooded Long-Evans rats were tested in a Morris water maze throughout the 3 weeks of pregnancy and the second week postpartum. Latency to platform, path length, swim velocity, and time in quadrant were compared over trial-days. To compare water maze performance with changes in hormone levels, serum concentrations of estradiol and progesterone were measured on the first, third, and fifth days of testing during the third week of pregnancy. Subjects learned to find the platform as indicated by decreased time and distance to platform over each trial-week and increased time spent in the quadrant where the platform had been located the previous week. However, there were no differences between treatment groups on time or distance to platform over trial-days. Swim velocity did not differ between or within groups over the 4 weeks of testing. Although primigravid and virgin females were similar in their abilities to learn the novel location of a submerged platform and return to it over time, pregnant animals demonstrated less perseveration to previously learned information and were quicker to locate the platform when it moved to a new location. Thus, reproductive status did not affect reference memory but enhanced working memory in the Morris water maze.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Bodensteiner KJ,Cain P,Ray AS,Hamula LA

doi

10.1016/j.yhbeh.2005.08.002

keywords:

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

303-14

issue

3

eissn

0018-506X

issn

1095-6867

pii

S0018-506X(05)00198-4

journal_volume

49

pub_type

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