Abstract：
:Corticotropin-releasing factor (CRF) plays a critical role in the mediation of physiological and behavioral responses to stressors. In the present study, we investigated the role played by the CRF system within the medial amygdala (MeA) in the modulation of anxiety and fear-related responses. Male Wistar rats were bilaterally administered into the MeA with CRF (125 and 250 ng/0.2μl, experiment 1) or with the CRFR1 antagonist antalarmin (25 ng/0.2 μl, experiment 2) and 10 min later tested in the elevated T-maze (ETM) for inhibitory avoidance and escape measurements. In clinical terms, these responses have been respectively related to generalized anxiety and panic disorder. To further verify if the anxiogenic effects of CRF were mediated by CRFR1 activation, we also investigated the effects of the combined treatment with CRF (250 ng/0.2 μl) and antalarmin (25 ng/0.2 μl) (experiment 3). All animals were tested in an open field, immediately after the ETM, for locomotor activity assessment. Results showed that CRF, in the two doses administered, facilitated ETM avoidance, an anxiogenic response. Antalarmin significantly decreased avoidance latencies, an anxiolytic effect, and was able to counteract the anxiogenic effects of CRF. None of the compounds administered altered escape responses or locomotor activity measurements. These results suggest that CRF in the MeA exerts anxiogenic effects by activating type 1 receptors, which might be of relevance to the physiopathology of generalized anxiety disorder.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Vicentini JE,Céspedes IC,Nascimento JO,Bittencourt JC,Viana MBdoi
10.1016/j.yhbeh.2014.01.004subject
Has Abstractpub_date
2014-03-01 00:00:00pages
195-202issue
3eissn
0018-506Xissn
1095-6867pii
S0018-506X(14)00005-1journal_volume
65pub_type
杂志文章abstract：:Exposure of female rats to estradiol during the perinatal period has profound effects on GABAergic neurotransmission that are crucial to establish sexually dimorphic brain characteristics. We previously showed that neonatal β-estradiol 3-benzoate (EB) treatment decreases brain concentrations of the neurosteroid allopr...
journal_title：Hormones and behavior
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doi：10.1016/j.yhbeh.2016.10.005
更新日期：2017-01-01 00:00:00
abstract：:Male Syrian hamsters (Mesocricetus auratus) administered anabolic/androgenic steroids during adolescent development display increased aggression and decreased anxious behavior during the adolescent exposure period. Upon withdrawal from anabolic/androgenic steroids, this neurobehavioral relationship shifts and hamsters...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.104650
更新日期：2020-03-01 00:00:00
abstract：:Female assessment of male attractiveness and how preferred qualities impact reproductive success is central to the study of mate choice. Male attractiveness may depend on traits beneficial to the reproductive success (RS) of any female, termed 'universal quality', and/or on behavioral and biological interactions betwe...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.10.009
更新日期：2012-01-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2008.01.014
更新日期：2008-05-01 00:00:00
abstract：:The adaptive value of social affiliation has been well established. It is unclear, however, what endogenous mechanisms may mediate affiliative behavior. The Australian zebra finch (Taeniopygia guttata) breeds colonially and adults maintain lifelong pair bonds that may be disrupted in the wild due to high mortality rat...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/s0018-506x(02)00012-0
更新日期：2003-01-01 00:00:00
abstract：:Testosterone (T) is often referred to as the "male hormone," but it can influence aggression, parental behavior, and immune function in both males and females. By experimentally relating hormone-induced changes in phenotype to fitness, it is possible to ask whether existing phenotypes perform better or worse than alte...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2013.03.005
更新日期：2013-05-01 00:00:00
abstract：:The present studies assessed the extent to which heterosexual pairmates could buffer marmosets (Wied's black tufted-ear marmoset, Callithrix kuhli) against stress. Six male and six female marmosets from established groups were exposed to two experimental manipulations together with a control condition. Each condition ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1998.1469
更新日期：1998-12-01 00:00:00
abstract：:Sexual behavior in female rats depends on the action of estradiol on estrogen receptors (ERs) found in particular brain regions. While hormonal regulation of female sexual behavior requires ERalpha, the possible functions of ERbeta remain to be clarified. Mating stimulation has several behavioral and physiological con...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/s0018-506x(03)00028-x
更新日期：2003-04-01 00:00:00
abstract：:Adrenal corticosterone secretion of newborn mice rapidly desensitizes to repeated maternal absence. The present study investigated the effects of novelty exposure, maternal care and genotype on this phenomenon. Maternal separation (MS) took place on postnatal days (pnd) 3-5. In Wistar rats, the degree of novelty in th...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.04.003
更新日期：2011-07-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1997.1379
更新日期：1997-06-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2017.07.015
更新日期：2017-09-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2009.04.006
更新日期：2009-06-01 00:00:00
abstract：:Conspicuous sexual swellings in the females of some primate species have been a focus of scientific interest since Darwin first wrote about them in 1871. To understand these visual signals, research focused on exaggerated sexual swellings of Old World primates. However, some primate species develop much smaller sexual...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2006.10.008
更新日期：2007-02-01 00:00:00
abstract：:The first issue of Hormones and Behavior was published 50 years ago in 1969, a time when most of the techniques we currently use in Behavioral Endocrinology were not available. Researchers have during the last 5 decades developed techniques that allow measuring hormones in small volumes of biological samples, identify...
journal_title：Hormones and behavior
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.yhbeh.2020.104682
更新日期：2020-02-01 00:00:00
abstract：:A field experiment was performed implanting female pied flycatchers (Ficedula hypoleuca) during the nest-building period with silastic tubes containing 17 beta-estradiol. Control females were given empty silastic tubes. The pied flycatcher is a polygamous and polyterritorial bird species. During two successive breedin...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(91)90038-j
更新日期：1991-03-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(85)90005-4
更新日期：1985-03-01 00:00:00
abstract：:Testosterone (T) appears to play a role in anxiety and sensorimotor gating in rodents, but whether T acts through the androgen receptor (AR) to influence these behaviors is less clear. We compared adult genetic male mice with the testicular feminization mutation (Tfm), which lack functional ARs, to wild type male litt...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2008.08.004
更新日期：2008-11-01 00:00:00
abstract：:Ovarian steroid hormones, estradiol and progesterone, regulate cellular functions in the central nervous system, resulting in the alterations in physiology and reproductive behavior. One means by which steroid hormones exert their neural effects on reproductive behavior is via their intracellular receptors functioning...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1006/hbeh.2001.1687
更新日期：2001-09-01 00:00:00
abstract：:Tonic immobility (TI) is also known as "immobility response", "immobility reflex", "animal hypnosis", etc. It is an innate antipredatory behavior characterized by an absence of movement, varying degrees of muscular activity, and a relative unresponsiveness to external stimuli. Experimentally, TI is commonly produced b...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.07.013
更新日期：2011-09-01 00:00:00
abstract：:We hypothesize that beneficial effects of estradiol on cognitive performance diminish with age and time following menopause due to a progressive decline in basal forebrain cholinergic function. This study tested whether galanthamine, a cholinesterase inhibitor used to treat memory impairment associated with Alzheimer'...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.08.010
更新日期：2011-11-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2012.11.007
更新日期：2013-01-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2004.07.001
更新日期：2004-12-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(87)90048-1
更新日期：1987-06-01 00:00:00
abstract：:In New World monkeys of the family Callitrichidae (marmosets and tamarins), females frequently give birth to dizygotic twins. Twins share a placental circulation throughout fetal development and are hemopoietic chimeras. Despite this, there is no masculinization (freemartinism) in females which develop next to a male ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1993.1016
更新日期：1993-06-01 00:00:00
abstract：:This study investigated the effect of exogenous 11-ketotestosterone (11KT) and testosterone (T), two important androgens involved in fish reproduction, as well as cyproterone acetate (CYA), an antiandrogen, on behaviors of male bluegill (Lepomis macrochirus) during prespawning and parental care periods. Parental male ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(91)90011-6
更新日期：1991-09-01 00:00:00
abstract：:Infant rats learn to prefer stimuli paired with pain, presumably due to the importance of learning to prefer the caregiver to receive protection and food. With maturity, a more 'adult-like' learning system emerges that includes the amygdala and avoidance/fear learning. The attachment and 'adult-like' systems appear to...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2007.06.004
更新日期：2007-09-01 00:00:00
abstract：:Since Arnold Adolph Berthold established in 1849 the critical role of the testes in the activation of male sexual behavior, intensive research has identified many sophisticated neurochemical and molecular mechanisms mediating this action. Studies in Japanese quail demonstrated the critical role of testosterone action ...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2017.05.017
更新日期：2017-07-01 00:00:00
abstract：:Responses to vibrotactile stimuli were examined in men as a function of chronic exposure to either exogenous or endogenous androgens. Psychophysical techniques were used to evaluate thresholds to stimulus detection and perceived stimulus intensities in response to mild vibration applied to either the finger or the pen...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(91)90050-r
更新日期：1991-06-01 00:00:00
abstract：:Most nonhuman primate research on risk factors underlying vulnerability to stress has focused on early psychosocial experiences in various species of macaques. To test for genetic and experiential effects on emotional vulnerability in randomly bred squirrel monkeys, here we combined a paternal half-sibling analysis wi...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1999.1547
更新日期：1999-12-01 00:00:00
abstract：:The evolutionary processes that result in reliable links between male signals and fighting capacity have received a great deal of attention, but the proximate mechanisms underlying such connections remain understudied. We studied a large sample of male green anole lizards (Anolis carolinensis) to determine whether tes...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2007.05.014
更新日期：2007-09-01 00:00:00
