Abstract:
:Recent reports support higher than expected rates of binge alcohol consumption among women and girls. Unfortunately, few studies have assessed the mechanisms underlying this pattern of intake in females. Studies in males suggest that alcohol concentrations relevant to the beginning stages of binge intoxication may selectively target tonic GABAergic inhibition mediated by GABAA receptor subtypes expressing the δ-subunit protein (δ-GABAARs). Indeed, administration of agonists that interact with these δ-GABAARs prior to alcohol access can abolish binge drinking behavior in male mice. These δ-GABAARs have also been shown to exhibit estrous-dependent plasticity in regions relevant to drug taking behavior, like the hippocampus and periaqueductal gray. The present experiments were designed to determine whether the estrous cycle would alter binge drinking, or our ability to modulate this pattern of alcohol use with THIP, an agonist with high selectivity and efficacy at δ-GABAARs. Using the Drinking-in-the-Dark (DID) binge-drinking model, regularly cycling female mice were given 2h of daily access to alcohol (20%v/v). Vaginal cytology or vaginal impedance was assessed after drinking sessions to track estrous status. There was no fluctuation in binge drinking associated with the estrous cycle. Both Intra-posterior-VTA administration of THIP and systemic administration of the drug was also associated with an estrous cycle dependent reduction in drinking behavior. Pre-treatment with finasteride to inhibit synthesis of 5α-reduced neurosteroids did not disrupt THIP's effects. Analysis of δ-subunit mRNA from posterior-VTA enriched tissue samples revealed that expression of this GABAA receptor subunit is elevated during diestrus in this region. Taken together, these studies demonstrate that δGABAARs in the VTA are an important target for binge drinking in females and confirm that the estrous cycle is an important moderator of the pharmacology of this GABAA receptor subtype.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Melón LC,Nolan ZT,Colar D,Moore EM,Boehm SL 2nddoi
10.1016/j.yhbeh.2017.07.015subject
Has Abstractpub_date
2017-09-01 00:00:00pages
65-75eissn
0018-506Xissn
1095-6867pii
S0018-506X(16)30276-8journal_volume
95pub_type
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
pub_type: 杂志文章
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更新日期:1998-12-01 00:00:00
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
pub_type: 杂志文章,评审
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1993.1007
更新日期:1993-03-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2012.11.017
更新日期:2013-03-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2016.06.012
更新日期:2016-09-01 00:00:00
abstract::Behavioral studies of an XY gonadal dysgenetic chacma baboon under estradiol benzoate treatment were carried out. The dysgenetic individual and two ovariectomized conspecific control females were given a total of three testing series. The dysgenetic individual showed progressive success in her sexual interactions with...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/0018-506x(84)90042-4
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abstract::Fathering behavior is critical for offspring survival in many species across diverse taxa, but our understanding of the neuroendocrine mechanisms regulating paternal care is limited in part because of the few primarily paternal species among the common animal models. However, many teleosts display primarily paternal c...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2018.06.006
更新日期:2018-07-01 00:00:00
abstract::Previous studies in our laboratory have shown that estradiol and progesterone affect beta-endorphin and Met-enkephalin levels in specific brain regions and that these effects are diurnally controlled. The present investigation was conducted to evaluate the effects of estradiol and progesterone on pain latency and brai...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1996.0029
更新日期:1996-09-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.2000.1572
更新日期:2000-05-01 00:00:00
abstract::Rodent alarm chemosignals elicit various behavioral and physiological responses in conspecifics. This study employed a bioassay method, using a modification of the forced swim test, to demonstrate that the pituitary mediates production and/or secretion of an alarm chemosignal in rats subjected to stress. This was show...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1994.1011
更新日期:1994-06-01 00:00:00
abstract::Social competence - the ability of animals to dynamically adjust their social behavior dependent on the current social context - is fundamental to the successful establishment and maintenance of social relationships in group-living species. The social opportunity paradigm, where animals rapidly ascend a social hierarc...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2016.11.001
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2004.04.006
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
pub_type: 杂志文章
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更新日期:1999-12-01 00:00:00
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journal_title:Hormones and behavior
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更新日期:2003-03-01 00:00:00
abstract::The intravenous injection of several corticosteroids in the spayed estrogen-primed rat resulted, 5 min later, in a remarkable induction of lordosis response for deoxycorticosterone and 11-deoxycortisol. A lower but important effect was induced with corticosterone and 17 alpha-hydroxyprogesterone. A chemical structure-...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/0018-506x(90)90033-t
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journal_title:Hormones and behavior
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abstract::Early life experiences are important for the development of neurobiobehavioral mechanisms and subsequent establishment of mental functions. In experimental animals, early life experiences can be studied using the maternal separation model. Maternal separation has been described to induce neurobiological changes and th...
journal_title:Hormones and behavior
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doi:10.1016/j.yhbeh.2006.06.016
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abstract::Corticotropin-releasing factor (CRF) plays a critical role in the mediation of physiological and behavioral responses to stressors. In the present study, we investigated the role played by the CRF system within the medial amygdala (MeA) in the modulation of anxiety and fear-related responses. Male Wistar rats were bil...
journal_title:Hormones and behavior
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更新日期:2014-03-01 00:00:00
abstract::In men, sexual orientation correlates with an individual's number of older brothers, each additional older brother increasing the odds of homosexuality by approximately 33%. It has been hypothesized that this fraternal birth order effect reflects the progressive immunization of some mothers to Y-linked minor histocomp...
journal_title:Hormones and behavior
pub_type: 杂志文章,评审
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2008.08.004
更新日期:2008-11-01 00:00:00
abstract::Although previous research has indicated that hormone replacement therapy benefits memory in menopausal women, several recent studies have shown either detrimental or no effects of treatment. These inconsistencies emphasize the need to evaluate the role of ovarian hormones in protecting against age-related cognitive d...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2010.03.018
更新日期:2010-07-01 00:00:00