Abstract:
:The intravenous injection of several corticosteroids in the spayed estrogen-primed rat resulted, 5 min later, in a remarkable induction of lordosis response for deoxycorticosterone and 11-deoxycortisol. A lower but important effect was induced with corticosterone and 17 alpha-hydroxyprogesterone. A chemical structure-biological effect analysis showed that C-21 hydroxylation (e.g., deoxycorticosterone, 11-deoxycortisol, and corticosterone) induces the behavioral effect. However, C-11 or C-17 hydroxylation alone promotes the lordosis response to a lesser degree (corticosterone and 17 alpha-hydroxyprogesterone, respectively). However, the effect of these latter compounds is significant. From the results, it is concluded that deoxycorticosterone and 11-deoxycortisol along with other steroids such as 20 alpha-hydroxyprogesterone are suitable candidates for synergizing the well-known estrogen-progesterone induction of lordotic behavior.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Kubli-Garfias Cdoi
10.1016/0018-506x(90)90033-tsubject
Has Abstractpub_date
1990-12-01 00:00:00pages
443-9issue
4eissn
0018-506Xissn
1095-6867journal_volume
24pub_type
杂志文章abstract::Experimental findings suggest that the melatonin system has a beneficial role in models of Alzheimer's disease (ADs). The aim of the present study was to explore whether the atypical antidepressant agomelatine (Ago), which is a melatonin MT1 and MT2 agonist and 5-HT2C antagonist, is effective against behavioral, bioch...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2018.11.007
更新日期:2019-01-01 00:00:00
abstract::Individually housed male mice were exposed to either an intact male or an ovariectomized female mouse for 1 min and decapitated at 5, 15, or 60 min to examine the hypothesis whether discrete changes in olfactory bulb neuropeptide (LHRH and TRH) and neurotransmitter (NE and DA) concentrations would occur following onse...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/0018-506x(83)90001-6
更新日期:1983-06-01 00:00:00
abstract::This confirmatory work is aimed to test that the hypothesis that the gastrin releasing peptide (GRP) receptor - the BB2 receptor - is necessary for reduction of meal size (MS) and prolongation of the intermeal interval (IMI) by the small and the large forms of GRP in the rat, GRP-10 and GRP-29, and to confirm the site...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2016.06.012
更新日期:2016-09-01 00:00:00
abstract::Since Arnold Adolph Berthold established in 1849 the critical role of the testes in the activation of male sexual behavior, intensive research has identified many sophisticated neurochemical and molecular mechanisms mediating this action. Studies in Japanese quail demonstrated the critical role of testosterone action ...
journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2017.05.017
更新日期:2017-07-01 00:00:00
abstract::A spawning pheromone in the milt (semen) and testes of the Pacific herring, Clupea harengus pallasi, is thought to facilitate school spawning of this species. We found that responsiveness to the spawning pheromone was variable among ripe fish (milt-producing or ovulated). Measurement of five principle reproductive ste...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1997.1379
更新日期:1997-06-01 00:00:00
abstract::In many anthropoid primates, mating activity is not restricted to the ovarian cycle but also occurs during pregnancy. Although it has been suggested that the main function of this post-conception mating is to confuse paternity, studies showing whether or not male primates can distinguish between the fertile phase of t...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2006.06.009
更新日期:2007-01-01 00:00:00
abstract::Testosterone (T) appears to play a role in anxiety and sensorimotor gating in rodents, but whether T acts through the androgen receptor (AR) to influence these behaviors is less clear. We compared adult genetic male mice with the testicular feminization mutation (Tfm), which lack functional ARs, to wild type male litt...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2008.08.004
更新日期:2008-11-01 00:00:00
abstract::Previous studies from our laboratory indicate that somatosensory inputs to the snout and ventral trunk, but not visual or auditory stimuli, play critical roles in the elicitation and maintenance of maternal aggression by lactating Norway rats toward a strange male intruder. There are conflicting reports on the influen...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1995.1285
更新日期:1995-12-01 00:00:00
abstract::Transient shifts in testosterone occur during competition and are thought to positively influence dominance behavior aimed at enhancing social status. However, individual differences in testosterone reactivity to status contests have not been well-studied in relation to real-time expressions of competitive behavior am...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2019.104665
更新日期:2020-07-01 00:00:00
abstract::Sex differences in incidence and severity of some stress-related, neuropsychiatric disorders are often reported to favor men, suggesting that women may be more vulnerable to aberrant hypothalamic-pituitary-adrenal (HPA) axis responses to stress. In this review, we discuss several investigations that we, and others, ha...
journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2009.06.003
更新日期:2010-01-01 00:00:00
abstract::Chronic stress in various forms increases the risk for cognitive dysfunction, dementia and Alzheimer's disease. While the pathogenesis behind these findings is unknown, growing evidence suggests that chronic increase in neurosteroid levels, such as allopregnanolone, is part of the mechanism. We treated wild-type C57BL...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2015.10.010
更新日期:2016-02-01 00:00:00
abstract::We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5-9years of age in birth cohorts from Greenland and Ukraine. P...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2017.11.007
更新日期:2018-05-01 00:00:00
abstract::Androgens act on the CNS to affect motor function through interaction with a widespread distribution of intracellular androgen receptors (AR). This review highlights our work on androgens and process outgrowth in motoneurons, both in vitro and in vivo. The actions of androgens on motoneurons involve the generation of ...
journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2008.01.014
更新日期:2008-05-01 00:00:00
abstract::Estrogens have been shown to be protective agents against neurodegeneration and associated cognitive decline in aging females. However, clinical data have been equivocal as to the benefits to the brain and cognition of estrogen therapy in postmenopausal women. One factor that is proposed to be critical in determining ...
journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2012.05.003
更新日期:2013-02-01 00:00:00
abstract::The gonadal hormone testosterone (T) regulates aggression across a wide range of vertebrate species. Recent evidence suggests that the adrenal prohormone dehydroepiandrosterone (DHEA) may also play an important role in regulating aggression. DHEA can be converted into active sex steroids, such as T and estradiol (E(2)...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2009.07.004
更新日期:2009-10-01 00:00:00
abstract::In most male birds that exhibit paternal care, extending the spring testosterone (T) peak throughout the breeding season reduces nestling provisioning. However, in some species, this trade-off between high T and expression of paternal care is absent. For example, during some or all of the nestling period, T did not af...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2004.10.004
更新日期:2005-02-01 00:00:00
abstract::Research was undertaken to study the role of central angiotensin in the modulation of male sexual behavior, testing the effect of angiotensin II (Ang II) injections into the medial amygdaloid nucleus (MeA). The sexual behavior of adult male Wistar rats was evaluated, 15 min after bilateral intra-amygdaloid microinject...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.2002.1771
更新日期:2002-05-01 00:00:00
abstract::Despite decades of laboratory research and clinical trials, a safe and effective treatment for traumatic brain injury (TBI) has yet to be put into successful clinical use. I suggest that much of the problem can be attributed to a reductionist perspective and attendant research strategy directed to finding or designing...
journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2012.05.004
更新日期:2013-02-01 00:00:00
abstract::There is broad acceptance for the idea that during development estradiol 'organizes' many aspects of reproductive behavior including partner preferences in the laboratory rat. With respect to partner preference, this idea is drawn from studies where estrogen action was in someway blocked, either through aromatase or e...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2008.08.009
更新日期:2009-01-01 00:00:00
abstract::To determine across-year patterns in plasma testosterone (T) and corticosterone (B) levels in free-living birds, we took blood samples in the same 2-week breeding period during 4 consecutive years from territorial male red-winged blackbirds. We used our data to test predictions of the "challenge hypothesis" of T secre...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/0018-506x(92)90011-j
更新日期:1992-09-01 00:00:00
abstract::Children exhibit gender-typical preferences in play, toys, activities and interests, and playmates. Several studies suggest that high concentrations of pre- and postnatal androgens contribute to male-typical behavior development, whereas female-typical behavior develops in the absence of high androgens levels. This st...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2007.01.001
更新日期:2007-03-01 00:00:00
abstract::The present study was carried out in order to assess the time course of action of progesterone (P) in the facilitation of complete feminine sexual behavior. Female rats (estrogen primed via 5% E2 Silastic capsules) were given 200 micrograms of P either intravenously (iv) or subcutaneously (sc), and tested for estrous ...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/0018-506x(83)90012-0
更新日期:1983-03-01 00:00:00
abstract::On any given day, about 35% of 80- to 85-day-old socially naïve male (SNM) lobster cockroaches (Nauphoeta cinerea) spontaneously adopted an aggressive posture (AP) without encountering another male [spontaneous AP (SAP)]. Although SAP SNMs showed significantly higher release of the pheromone 3-hydroxy-2-butanone (3H-2...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2007.04.013
更新日期:2007-08-01 00:00:00
abstract::Male Syrian hamsters (Mesocricetus auratus) administered anabolic/androgenic steroids during adolescent development display increased aggression and decreased anxious behavior during the adolescent exposure period. Upon withdrawal from anabolic/androgenic steroids, this neurobehavioral relationship shifts and hamsters...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2019.104650
更新日期:2020-03-01 00:00:00
abstract::Rodent alarm chemosignals elicit various behavioral and physiological responses in conspecifics. This study employed a bioassay method, using a modification of the forced swim test, to demonstrate that the pituitary mediates production and/or secretion of an alarm chemosignal in rats subjected to stress. This was show...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1994.1011
更新日期:1994-06-01 00:00:00
abstract::Relationships between testosterone plasma levels and evoked vocal responses of males of the leptodactylid frog Batrachyla taeniata from southern Chile were studied. Evoked vocal responses were elicited in the field with playbacks of a synthetic imitation of the conspecific advertisement call and variants of this signa...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1997.1366
更新日期:1997-04-01 00:00:00
abstract::Previous studies have shown that melatonin is implicated in modulating learning and memory processing. Melatonin also exerts neuroprotective activities against Aβ-induced injury in vitro and in vivo. Neu-P11 (piromelatine, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-4-oxo-4H-pyran-2-carboxamide) is a novel melatonin (MT1/MT2...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2013.04.009
更新日期:2013-06-01 00:00:00
abstract::In New World monkeys of the family Callitrichidae (marmosets and tamarins), females frequently give birth to dizygotic twins. Twins share a placental circulation throughout fetal development and are hemopoietic chimeras. Despite this, there is no masculinization (freemartinism) in females which develop next to a male ...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1993.1016
更新日期:1993-06-01 00:00:00
abstract::Previous studies have documented the ability of neural grafts to stimulate the recovery of lordosis from neurochemical deficits. However, it was unclear if grafts also could reverse deficits in lordosis caused by lesions at critical points in the neural circuit controlling this response. To address this question, fema...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1006/hbeh.1997.1421
更新日期:1997-12-01 00:00:00
abstract::This article is part of a Special Issue "Puberty and Adolescence". This paper examines consistency of effects of pubertal timing (going through puberty earlier, later or at the same time one's cohort of peers) on the development of psychopathology during adolescence as well as the persistence of effects into adulthood...
journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2013.04.003
更新日期:2013-07-01 00:00:00