Chemical structure of corticosteroids and its relationship with their acute induction of lordosis in the female rat.

Abstract:

:The intravenous injection of several corticosteroids in the spayed estrogen-primed rat resulted, 5 min later, in a remarkable induction of lordosis response for deoxycorticosterone and 11-deoxycortisol. A lower but important effect was induced with corticosterone and 17 alpha-hydroxyprogesterone. A chemical structure-biological effect analysis showed that C-21 hydroxylation (e.g., deoxycorticosterone, 11-deoxycortisol, and corticosterone) induces the behavioral effect. However, C-11 or C-17 hydroxylation alone promotes the lordosis response to a lesser degree (corticosterone and 17 alpha-hydroxyprogesterone, respectively). However, the effect of these latter compounds is significant. From the results, it is concluded that deoxycorticosterone and 11-deoxycortisol along with other steroids such as 20 alpha-hydroxyprogesterone are suitable candidates for synergizing the well-known estrogen-progesterone induction of lordotic behavior.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Kubli-Garfias C

doi

10.1016/0018-506x(90)90033-t

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

443-9

issue

4

eissn

0018-506X

issn

1095-6867

journal_volume

24

pub_type

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