Long-term continuous allopregnanolone elevation causes memory decline and hippocampus shrinkage, in female wild-type B6 mice.


:Chronic stress in various forms increases the risk for cognitive dysfunction, dementia and Alzheimer's disease. While the pathogenesis behind these findings is unknown, growing evidence suggests that chronic increase in neurosteroid levels, such as allopregnanolone, is part of the mechanism. We treated wild-type C57BL/6J mice with allopregnanolone for 5months, using osmotic pumps. This treatment led to moderately increased levels of allopregnanolone, equivalent to that of mild chronic stress. After an interval of no treatment for 1month, female mice showed impaired learning and memory function in the Morris water maze (MWM) in combination with diminished hippocampus weight and increased cerebellum weight, both correlating to MWM performance. Male mice showed a minor reduction in memory function and no differences in brain structure. We conclude that chronic allopregnanolone elevation can lead to cognitive dysfunction and negative brain alterations. We suggest that allopregnanolone could play a key role in the pathogenesis of stress-induced cognitive disturbances and perhaps dementia.


Horm Behav


Hormones and behavior


Bengtsson SK,Johansson M,Bäckström T




Has Abstract


2016-02-01 00:00:00












  • The role of oxytocin in mating and pregnancy.

    abstract::The hormone oxytocin (OT) is released both centrally and peripherally during and after mating. Although research in humans suggests a central role in sexuality, the most reliable findings to date involve peripheral activation. This review will discuss these results and will particularly focus on understanding the most...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审


    authors: Borrow AP,Cameron NM

    更新日期:2012-03-01 00:00:00

  • Estrogen increases the sensitivity of ovariectomized rats to the disruptive effects produced by antagonism of D2 but not D1 dopamine receptors during performance of a response learning task.

    abstract::Estrogen impairs performance on some striatum-sensitive tasks of learning and memory. Evidence indicates that it may have these impairing effects by creating a bias to use hippocampally based strategies to solve tasks whether or not it is advantageous to do so. Estrogen may also exert direct effects in the striatum to...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Daniel JM,Sulzer JK,Hulst JL

    更新日期:2006-01-01 00:00:00

  • Context-dependent effects of castration and testosterone treatment on song in male European starlings.

    abstract::Most seasonally breeding songbirds display dramatic seasonal fluctuations in plasma testosterone (T) levels and mate attraction behaviors, including song. However, males of some songbird species, such as the European starling (Sturnus vulgaris), continue to sing at high levels after the breeding season, when T levels ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Pinxten R,De Ridder E,Balthazart J,Eens M

    更新日期:2002-11-01 00:00:00

  • Behavioral depression: opposite effects of neonatal dexamethasone and ACTH-(4-9) analogue (ORG 2766) treatments in the rat.

    abstract::Permanent changes in novelty-induced arousal and behavioral depression were studied in adult male Wistar rats having received sc injections of 1 micrograms/g body wt dexamethasone (DEX) or ACTH-(4-9) analogue (ORG 2766), or the combined treatment of these substances at Postnatal Days 1, 3, and 5. Treatment with DEX in...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Felszeghy K,Sasvári M,Nyakas C

    更新日期:1993-09-01 00:00:00

  • Attractivity of male and female rats which are hormonally manipulated during early development and in adulthood.

    abstract::Attractivity is one aspect of female sexuality relevant for the understanding of male-female sexual interactions. In a previous study, it was shown that intact males were equally attracted to early androgenized, gonadally intact females as to normally developed, estrous females. The present study was designed to inves...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: de Jonge FH,Meyerson BJ,van de Poll NE

    更新日期:1986-12-01 00:00:00

  • Melatonin reduces arousal and startle responsiveness without influencing startle habituation or affective startle modulation in young women.

    abstract::Melatonin has been suggested to affect human emotion, but conflicting evidence exists. Therefore, we tested the effect of a single dose of a 4 mg prolonged release formulation of melatonin on a biologically based model of emotional processing. Affective modulation of acoustic white noise startle (103 dB) by emotional ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,随机对照试验


    authors: Schachinger H,Blumenthal TD,Richter S,Savaskan E,Wirz-Justice A,Kräuchi K

    更新日期:2008-08-01 00:00:00

  • The relationship between social status, behaviour, growth and steroids in male helpers and breeders of a cooperatively breeding cichlid.

    abstract::We tested whether subordinate helper males of the Lake Tanganyika cooperatively breeding cichlid Neolamprologus pulcher show elevated excretion levels of the stress hormone cortisol and reduced levels of 11-ketotestosterone and testosterone when living in groups with a small breeder male, compared to similar helper ma...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Bender N,Heg D,Hamilton IM,Bachar Z,Taborsky M,Oliveira RF

    更新日期:2006-08-01 00:00:00

  • Hormonal contraceptive use and mate retention behavior in women and their male partners.

    abstract::Female hormonal contraceptive use has been associated with a variety of physical and psychological side effects. Women who use hormonal contraceptives report more intense affective responses to partner infidelity and greater overall sexual jealousy than women not using hormonal contraceptives. Recently, researchers ha...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Welling LL,Puts DA,Roberts SC,Little AC,Burriss RP

    更新日期:2012-01-01 00:00:00

  • GOAT induced ghrelin acylation regulates hedonic feeding.

    abstract::Ghrelin is an orexigenic hormone that regulates homeostatic and reward-related feeding behavior. Recent evidence indicates that acylation of ghrelin by the gut enzyme ghrelin O-acyl transferase (GOAT) is necessary to render ghrelin maximally active within its target tissues. Here we tested the hypothesis that GOAT act...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Davis JF,Perello M,Choi DL,Magrisso IJ,Kirchner H,Pfluger PT,Tschoep M,Zigman JM,Benoit SC

    更新日期:2012-11-01 00:00:00

  • ESR1 polymorphisms, daily hassles, anger expression, and depressive symptoms in adolescent boys and girls.

    abstract::Studies reporting associations between genetic factors and mood-related traits have often been criticized (i) for failing to take into account the role of the social environment in which individuals act and (ii) for not maintaining a 'transparent narrative connection' between genes and outcomes. In a sample of adolesc...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Vermeersch H,T'sjoen G,Kaufman JM,Van Houtte M

    更新日期:2013-03-01 00:00:00

  • Studies on effects of tamoxifen (ICI 46474) on agonistic encounters between pairs of intact mice.

    abstract::The anti-estrogen tamoxifen (Tam), which has been shown to dramatically suppress offensive behavior in male rats without markedly influencing other aspects of the social encounter, was tested for its effectiveness in mice. TO strain albino mice were given control injections or 50 or 100 micrograms of Tam for 4 or 8 da...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Hasan SA,Brain PF,Castano D

    更新日期:1988-06-01 00:00:00

  • Antidepressant agomelatine attenuates behavioral deficits and concomitant pathology observed in streptozotocin-induced model of Alzheimer's disease in male rats.

    abstract::Experimental findings suggest that the melatonin system has a beneficial role in models of Alzheimer's disease (ADs). The aim of the present study was to explore whether the atypical antidepressant agomelatine (Ago), which is a melatonin MT1 and MT2 agonist and 5-HT2C antagonist, is effective against behavioral, bioch...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Ilieva K,Tchekalarova J,Atanasova D,Kortenska L,Atanasova M

    更新日期:2019-01-01 00:00:00

  • Estrogen therapy and brain muscarinic receptor density in healthy females: a SPET study.

    abstract::Estrogen Therapy (ET) may protect against age-related cognitive decline and neuropsychiatric disorders (e.g. Alzheimer's disease). The biological basis for this putative neuroprotective effect is not fully understood, but may include modulation of cholinergic systems. Cholinergic dysfunction has been implicated in age...

    journal_title:Hormones and behavior

    pub_type: 临床试验,杂志文章


    authors: Norbury R,Travis MJ,Erlandsson K,Waddington W,Ell PJ,Murphy DG

    更新日期:2007-02-01 00:00:00

  • Ecoimmunology and microbial ecology: Contributions to avian behavior, physiology, and life history.

    abstract::Bacteria have had a fundamental impact on vertebrate evolution not only by affecting the evolution of the immune system, but also generating complex interactions with behavior and physiology. Advances in molecular techniques have started to reveal the intricate ways in which bacteria and vertebrates have coevolved. He...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审


    authors: Evans JK,Buchanan KL,Griffith SC,Klasing KC,Addison B

    更新日期:2017-02-01 00:00:00

  • Hormonal correlates of breeding status, nest construction, and parental care in multiple-brooded northern mockingbirds, Mimus polyglottos.

    abstract::Blood samples were taken from free-living male and female mockingbirds to determine correlations between plasma steroids and breeding behavior. Plasma levels of testosterone (T), estradiol (E2), progesterone (P), and corticosterone (B) were assessed during pre-breeding courtship, while males built nests, while females...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Logan CA,Wingfield JC

    更新日期:1995-03-01 00:00:00

  • Testicular hormone exposure during adolescence organizes flank-marking behavior and vasopressin receptor binding in the lateral septum.

    abstract::Adolescence is a period during which many social behaviors emerge. One such behavior, flank marking, is a testosterone-modulated scent marking behavior that communicates dominance status between adult male Syrian hamsters. Testosterone modulates flank-marking behavior by altering neural transmission of vasopressin wit...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Schulz KM,Menard TA,Smith DA,Albers HE,Sisk CL

    更新日期:2006-09-01 00:00:00

  • The face of female dominance: Women with dominant faces have lower cortisol.

    abstract::The human face displays a wealth of information, including information about dominance and fecundity. Dominance and fecundity are also associated with lower concentrations of the stress hormone cortisol, suggesting that cortisol may negatively predict facial dominance and attractiveness. We digitally photographed 61 w...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Gonzalez-Santoyo I,Wheatley JR,Welling LL,Cárdenas RA,Jimenez-Trejo F,Dawood K,Puts DA

    更新日期:2015-05-01 00:00:00

  • Disruption of seasonality in growth hormone-transgenic coho salmon (Oncorhynchus kisutch) and the role of cholecystokinin in seasonal feeding behavior.

    abstract::Seasonal variation in daily food intake is a well-documented phenomenon in many organisms including wild-type coho salmon where the appetite is noticeably reduced during periods of decreased day length and low water temperature. This reduction may in part be explained by altered production of cholecystokinin (CCK) and...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Lõhmus M,Raven PA,Sundström LF,Devlin RH

    更新日期:2008-09-01 00:00:00

  • Selectivity in the responses of hamsters to conspecific vocalizations.

    abstract::Lordosis responses by estrous hamsters were triggered by brief manual stimulation. Lordosis durations then were timed, as manual stimulation was discontinued, and subjects were exposed to tape-recordings of conspecific vocalizations reproduced at intensities of 0-60 dB SPL. Relative to the durations observed in the pr...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Floody OR,Bauer GB

    更新日期:1987-12-01 00:00:00

  • Systemic ICI 182,780 alters the display of sexual behaviors in the female rat.

    abstract::The present study investigates the effects of the antiestrogen ICI 182,780 (ICI) on the display of sexual behaviors in female rats. ICI 182,780 is a pure anti-estrogen and when given systemically, ICI is thought to act only in the periphery, and is not believed to cross the blood brain barrier. The present study exami...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Gardener HE,Clark AS

    更新日期:2001-03-01 00:00:00

  • Within seasons and among years: when are corticosterone levels repeatable?

    abstract::Hormones play a central role in integrating internal and external cues to help mediate life-history decisions as well as changes in behavior and physiology of individuals. Describing the consistency of endocrine traits within and among individuals is an important step for understanding whether hormonal traits are depe...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Ouyang JQ,Hau M,Bonier F

    更新日期:2011-11-01 00:00:00

  • Sex-dependent effects of social status on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT), and serotonin (5-HT) 1A receptor binding and aggression in Syrian hamsters (Mesocricetus auratus).

    abstract::Dominance status in hamsters is driven by interactions between arginine-vasopressin V1a, oxytocin (OT), and serotonin 1A (5-HT1A) receptors. Activation of V1a and OT receptors in the anterior hypothalamus (AH) increases aggression in males, while decreasing aggression in females. In contrast, activation of 5-HT1A rece...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Grieb ZA,Ross AP,McCann KE,Lee S,Welch M,Gomez MG,Norvelle A,Michopoulos V,Huhman KL,Albers HE

    更新日期:2021-01-01 00:00:00

  • Recovery periods during repeated stress impact corticosterone and behavioral responses differently in house sparrows.

    abstract::A number of studies have shown that chronic stress can negatively impact both physiology and behavior in a variety of organisms. What has yet to be extensively explored is whether these changes permanently alter an animal's functioning, or if they can be reversed. In this study, we used wild-caught house sparrows (Pas...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Gormally BMG,Ramos S,Yin H,Romero LM

    更新日期:2019-06-01 00:00:00

  • Androgen receptors are required for full masculinization of nitric oxide synthase system in rat limbic-hypothalamic region.

    abstract::The neuronal nitric oxide synthase (nNOS) is involved in the control of male and female sexual behavior and its distribution in several regions of the limbic-hypothalamic system, as well as its coexistence with gonadal hormones' receptors, suggests that these hormones may play a significant role in controlling its exp...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Martini M,Di Sante G,Collado P,Pinos H,Guillamon A,Panzica GC

    更新日期:2008-09-01 00:00:00

  • Progestins can have a membrane-mediated action in rat midbrain for facilitation of sexual receptivity.

    abstract::In rats, progesterone (P) facilitates sexual receptivity by interacting with intracellular progestin receptors in the ventromedial hypothalamus (VMH). This experiment concerns whether P can also facilitate receptivity in rats by acting extragenomically within the ventral tegmental area (VTA). Ovariectomized rats (n = ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Frye CA,Gardiner SG

    更新日期:1996-12-01 00:00:00

  • Plasma membrane G protein-coupled estrogen receptor 1 (GPER) mediates rapid estradiol facilitation of sexual receptivity through the orphanin-FQ-ORL-1 system in estradiol primed female rats.

    abstract::In estradiol-primed nonreceptive ovariectomized rats, activation of G protein-coupled estrogen receptor 1 (GPER) in the arcuate nucleus of the hypothalamus (ARH) rapidly facilitates sexual receptivity (lordosis). Estradiol priming activates ARH β-endorphin (β-END) neurons that then activate medial preoptic (MPN) μ-opi...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Tominna R,Chokr S,Feri M,Chuon T,Sinchak K

    更新日期:2019-06-01 00:00:00

  • Effects of long-term treatment with 17 beta-estradiol and medroxyprogesterone acetate on water maze performance in middle aged female rats.

    abstract::Although previous research has indicated that hormone replacement therapy benefits memory in menopausal women, several recent studies have shown either detrimental or no effects of treatment. These inconsistencies emphasize the need to evaluate the role of ovarian hormones in protecting against age-related cognitive d...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Lowry NC,Pardon LP,Yates MA,Juraska JM

    更新日期:2010-07-01 00:00:00

  • Is preference for ovulatory female's faces associated with men's testosterone levels?

    abstract::Women's ovulation is perceivable with different senses. Already subtle face shape differences are enough to trigger men's preference for the ovulatory female. The aim of the present study is to investigate if men's testosterone level can be linked to their preference for the ovulatory female. Thirty-nine heterosexual ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,随机对照试验


    authors: Bobst C,Lobmaier JS

    更新日期:2014-08-01 00:00:00

  • Activation of ERβ modulates fear generalization through an effect on memory retrieval.

    abstract::Women are 60% more likely to suffer from an anxiety disorder than men. One hypothesis for this difference may be that females exhibit increased rates of fear generalization. Females generalize fear to a neutral context faster than males, a process driven, in part, by estrogens. In the current study, ovariectomized adu...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Lynch JF 3rd,Dejanovic D,Winiecki P,Mulvany J,Ortiz S,Riccio DC,Jasnow AM

    更新日期:2014-07-01 00:00:00

  • Divorce in the socially monogamous zebra finch: Hormonal mechanisms and reproductive consequences.

    abstract::Up to 80% of all bird species are socially monogamous. Divorce (switching partners) or pair disruption (due to the death of a partner) has been associated with decreased reproductive success, suggesting social monogamy is a strategy that may maximize fitness via coordination between partners. Previous studies have dem...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Crino OL,Buchanan KL,Fanson BG,Hurley LL,Smiley KO,Griffith SC

    更新日期:2017-01-01 00:00:00