Long-term continuous allopregnanolone elevation causes memory decline and hippocampus shrinkage, in female wild-type B6 mice.


:Chronic stress in various forms increases the risk for cognitive dysfunction, dementia and Alzheimer's disease. While the pathogenesis behind these findings is unknown, growing evidence suggests that chronic increase in neurosteroid levels, such as allopregnanolone, is part of the mechanism. We treated wild-type C57BL/6J mice with allopregnanolone for 5months, using osmotic pumps. This treatment led to moderately increased levels of allopregnanolone, equivalent to that of mild chronic stress. After an interval of no treatment for 1month, female mice showed impaired learning and memory function in the Morris water maze (MWM) in combination with diminished hippocampus weight and increased cerebellum weight, both correlating to MWM performance. Male mice showed a minor reduction in memory function and no differences in brain structure. We conclude that chronic allopregnanolone elevation can lead to cognitive dysfunction and negative brain alterations. We suggest that allopregnanolone could play a key role in the pathogenesis of stress-induced cognitive disturbances and perhaps dementia.


Horm Behav


Hormones and behavior


Bengtsson SK,Johansson M,Bäckström T




Has Abstract


2016-02-01 00:00:00












  • Behavioral and neuroendocrine actions of the Met-enkephalin-related peptide MERF.

    abstract::The effects and the mediation of the action of the proenkephalin derivative Met(5)-enkephalin-Arg(6)-Phe(7) (MERF) on the hypothalamo-pituitary-adrenal (HPA) system and open-field behavior were investigated in mice. Intracerebroventricular injection of the heptapeptide increased square crossing, rearing, and plasma co...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Bujdosó E,Jászberényi M,Farkas J,Tóth G,Wollemann M,Telegdy G

    更新日期:2003-02-01 00:00:00

  • Energy balance but not competitive environment corresponds with allostatic load during development in an Old World monkey.

    abstract::Primates develop slowly relative to their body size, a pattern posited to result from ecological risk aversion. Little is known, however, about how energy balance contributes to allostatic load in juveniles. Using data collected over 8 consecutive months, we examined variation in energy balance (as measured by urinary...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,收录出版


    authors: Thompson NA,Higham JP,Heistermann M,Vogel E,Cords M

    更新日期:2019-02-01 00:00:00

  • Testosterone, endurance, and Darwinian fitness: natural and sexual selection on the physiological bases of alternative male behaviors in side-blotched lizards.

    abstract::The mechanistic bases of natural and sexual selection on physiological and behavioral traits were examined in male morphs of three colors of the side-blotched lizard, Uta stansburiana. Orange-throated males are aggressive and defend large territories with many females. Blue-throated males defend smaller territories wi...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Sinervo B,Miles DB,Frankino WA,Klukowski M,DeNardo DF

    更新日期:2000-12-01 00:00:00

  • Local glucocorticoid production in lymphoid organs of mice and birds: Functions in lymphocyte development.

    abstract::Circulating glucocorticoids (GCs) are powerful regulators of immunity. Stress-induced GC secretion by the adrenal glands initially enhances and later suppresses the immune response. GC targets include lymphocytes of the adaptive immune system, which are well known for their sensitivity to GCs. Less appreciated, howeve...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审


    authors: Taves MD,Hamden JE,Soma KK

    更新日期:2017-02-01 00:00:00

  • The role of vocal self-stimulation in female responses to males: implications for state-reading.

    abstract::As research neurobiologists, we pursue specific questions, and the answers rendered are also correspondingly specific. Our goal, however, is to understand an entire system or the whole organism. To that end, it is not only useful, but sometimes also necessary, that we periodically reappraise a body of specific data in...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审


    authors: Cheng MF

    更新日期:2008-01-01 00:00:00

  • Acute stress impairs recall after interference in older people, but not in young people.

    abstract::Stress has been associated with negative changes observed during the aging process. However, very little research has been carried out on the role of age in acute stress effects on memory. We aimed to explore the role of age and sex in the relationship between hypothalamus-pituitary-adrenal axis (HPA-axis) and sympath...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Hidalgo V,Almela M,Villada C,Salvador A

    更新日期:2014-03-01 00:00:00

  • Light as a modulator of emotion and cognition: Lessons learned from studying a diurnal rodent.

    abstract::Light profoundly affects the behavior and physiology of almost all animals, including humans. One such effect in humans is that the level of illumination during the day positively contributes to affective well-being and cognitive function. However, the neural mechanisms underlying the effects of daytime light intensit...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审


    authors: Yan L,Lonstein JS,Nunez AA

    更新日期:2019-05-01 00:00:00

  • Systemic ICI 182,780 alters the display of sexual behaviors in the female rat.

    abstract::The present study investigates the effects of the antiestrogen ICI 182,780 (ICI) on the display of sexual behaviors in female rats. ICI 182,780 is a pure anti-estrogen and when given systemically, ICI is thought to act only in the periphery, and is not believed to cross the blood brain barrier. The present study exami...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Gardener HE,Clark AS

    更新日期:2001-03-01 00:00:00

  • Regulation of social behaviors by p-Stat3 via oxytocin and its receptor in the nucleus accumbens of male Brandt's voles (Lasiopodomys brandtii).

    abstract::Social behavior plays a significant role in the formation of social structure and population regulation in both animals and humans. Oxytocin (OXT) and its receptor (OXTR) are well known for regulating social behaviors, but their upstream regulating factors are rarely investigated. We hypothesized that the phosphorylat...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Yan L,Sun X,Wang Z,Song M,Zhang Z

    更新日期:2020-03-01 00:00:00

  • Does the interaction between partnership status and average progesterone level predict women's preferences for facial masculinity?

    abstract::Many studies have attempted to identify biological factors that reliably predict individual differences in women's preferences for masculine male faces. Marcinkowska et al. (2018, Hormones & Behavior) recently reported that women's (N = 102) preferences for facial masculinity were predicted by the interaction between ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: DeBruine LM,Hahn AC,Jones BC

    更新日期:2019-01-01 00:00:00

  • Further evidence for masculinization of female rats by males located caudally in utero.

    abstract::The morphology and behavior of female rodents is partially masculinized as a result of residence near males in the same uterine horn (Clemens effect). Two hypothetical mechanisms have been proposed to account for this effect. In the first hypothesis ("contiguity") androgens secreted by males in utero are proposed to d...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Richmond G,Sachs BD

    更新日期:1984-12-01 00:00:00

  • Effect of a vasotocin analog on singing behavior in the canary.

    abstract::Groups of juvenile and 1-year-old male canaries were treated briefly with the vasotocin (VT) analog desGly(NH2)9d(CH2)5-[Tyr(Me)2,Thr4, Orn8]VT (dGVTA) during four time intervals between September and February. The canaries received subcutaneously testosterone-containing silastic implants at the start of the VT analog...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Voorhuis TA,De Kloet ER,De Wied D

    更新日期:1991-12-01 00:00:00

  • The relationship between dominance, corticosterone, memory, and food caching in mountain chickadees (Poecile gambeli).

    abstract::It has been hypothesized that in avian social groups subordinate individuals should maintain more energy reserves than dominants, as an insurance against increased perceived risk of starvation. Subordinates might also have elevated baseline corticosterone levels because corticosterone is known to facilitate fattening ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Pravosudov VV,Mendoza SP,Clayton NS

    更新日期:2003-08-01 00:00:00

  • Clitoral stimulation induces conditioned place preference and Fos activation in the rat.

    abstract::The present study examined the ability of clitoral stimulation (CLS) to induce conditioned place preference (CPP) and Fos protein in the brain. Ovariectomized, hormone-primed Long-Evans rats were randomly assigned to receive either distributed CLS (1 stimulation every 5 s for 1 min prior to being placed in one distinc...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Parada M,Chamas L,Censi S,Coria-Avila G,Pfaus JG

    更新日期:2010-02-01 00:00:00

  • Early life stress and cortisol: A meta-analysis.

    abstract::Given the high prevalence of early life stress (ELS) and the potential physiological dysregulation such experiences can lead to, this meta-analysis tested the relationship between ELS and cortisol. Search terms related to ELS and cortisol were entered in to PsycINFO and PubMed. Effect sizes were extracted for four out...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,meta分析,评审


    authors: Fogelman N,Canli T

    更新日期:2018-02-01 00:00:00

  • Gonadal hormones in female rats protect against dehydration-induced memory impairments in the novel object recognition paradigm.

    abstract::Dehydration impairs cognitive performance in humans and rodents, although studies in animal models are limited. Estrogens have both protective effects on fluid regulation and improve performance in certain cognitive tasks. We, therefore, tested whether sex and gonadal hormones influence object recognition memory durin...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Santollo J,Myers KE,Rainer IL,Edwards AA

    更新日期:2019-08-01 00:00:00

  • Influence of gonadal sex hormones on behavioral components of the reproductive hierarchy in naked mole-rats.

    abstract::Naked mole-rats (Heterocephalus glaber) are fossorial, eusocial rodents that live in colonies which typically include 60-80 individuals. Generally, only one of the females and 1-3 of the males in a colony are reproductives. The reproductives engage in mutual genital nuzzling behavior that is rarely exhibited by subord...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Goldman SL,Forger NG,Goldman BD

    更新日期:2006-06-01 00:00:00

  • How prior pair-bonding experience affects future bonding behavior in monogamous prairie voles.

    abstract::Monogamous prairie voles (Microtus ochrogaster) form mating-based pair bonds. Although wild prairie voles rarely re-pair following loss of a partner, laboratory studies have shown that previous pairing and mating does not negate the ability to form a new partner preference. However, little is known about how prior bon...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Harbert KJ,Pellegrini M,Gordon KM,Donaldson ZR

    更新日期:2020-11-01 00:00:00

  • The influence of androgenic and estrogenic hormones on sexual behavior in castrated adult male pigs.

    abstract::The objectives of these studies were to evaluate the influence of testosterone propionate (TP), estradiol cypionate (EC), dihydrotestosterone propionate (DHTP), EC + TP, EC + DHTP, and TP + DHTP on traits of masculine sexual behavior in castrated adult male pigs of different breeds. Masculine sexual behavior was resto...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Levis DG,Ford JJ

    更新日期:1989-09-01 00:00:00

  • Corticosterone microinjected into nucleus pontis oralis increases tonic immobility in rats.

    abstract::Tonic immobility (TI) is also known as "immobility response", "immobility reflex", "animal hypnosis", etc. It is an innate antipredatory behavior characterized by an absence of movement, varying degrees of muscular activity, and a relative unresponsiveness to external stimuli. Experimentally, TI is commonly produced b...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Sandoval-Herrera V,Trujillo-Ferrara JG,Miranda-Páez A,De La Cruz F,Zamudio SR

    更新日期:2011-09-01 00:00:00

  • Fraternal birth order and the maternal immune hypothesis of male homosexuality.

    abstract::In men, sexual orientation correlates with an individual's number of older brothers, each additional older brother increasing the odds of homosexuality by approximately 33%. It has been hypothesized that this fraternal birth order effect reflects the progressive immunization of some mothers to Y-linked minor histocomp...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审


    authors: Blanchard R

    更新日期:2001-09-01 00:00:00

  • Sex-specific mediation of foraging in the shore crab, Carcinus maenas.

    abstract::Experiments were conducted to investigate the sex-specific differences to feeding responses of the shore crab Carcinus maenas throughout the year. Results demonstrate that female shore crabs exhibit stronger feeding responses than males throughout the year with a significantly reduced feeding response in males during ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Hayden D,Jennings A,Müller C,Pascoe D,Bublitz R,Webb H,Breithaupt T,Watkins L,Hardege J

    更新日期:2007-08-01 00:00:00

  • The role of gonadal steroid receptor activation in the restoration of sociosexual behavior in adult male rats.

    abstract::This work tested the hypothesis that gonadal steroid receptor activation was necessary for the restoration of several sociosexual behaviors (such as copulatory behavior, partner preference, 50-kHz vocalizations, and scent marking) in testosterone-treated gonadectomized male rats. Gonadal steroid receptors were blocked...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Vagell ME,McGinnis MY

    更新日期:1998-06-01 00:00:00

  • The effect of chronic administration of corticosterone on anxiety- and depression-like behavior and the expression of GABA-A receptor alpha-2 subunits in brain structures of low- and high-anxiety rats.

    abstract::The aim of this study was to examine changes in rat emotional behavior and determine differences in the expression of GABA-A receptor alpha-2 subunits in brain structures of low- (LR) and high-anxiety (HR) rats after the repeated corticosterone administration. The animals were divided into LR and HR groups based on th...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Skórzewska A,Lehner M,Wisłowska-Stanek A,Krząścik P,Ziemba A,Płaźnik A

    更新日期:2014-01-01 00:00:00

  • Effects of opioid- and non-opioid analgesics on responses to psychosocial stress in humans.

    abstract::Both preclinical and clinical evidence suggests that the endogenous opioid system is involved in responses to stress. For example, in animal models opioid agonists reduce isolation distress whereas opioid antagonists increase isolation distress. We recently reported that the mixed mu agonist and kappa antagonist bupre...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,随机对照试验


    authors: Bershad AK,Miller MA,Norman GJ,de Wit H

    更新日期:2018-06-01 00:00:00

  • Mating call phonotaxis in female American toad: lesions of anterior preoptic nucleus.

    abstract::Lesions of the preoptic area and immediately adjacent septal area were made in female American toads, Bufo americanus. The ability to show mating call phonotaxis (MCP) was then tested for. The intensity of MCP was found to decrease as the degree of damage to the anterior tip of the anterior preoptic nucleus (APON) inc...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Schmidt RS

    更新日期:1989-03-01 00:00:00

  • Early experience alters developmental trajectory of central oxytocin systems involved in hypothalamic-pituitary-adrenal axis regulation in Long-Evans rats.

    abstract::Oxytocin is important for postnatal developmental experiences for mothers, infants, and transactions between them. Oxytocin is also implicated in adult affiliative behaviors, including social buffering of stress. There is evidence for connections between early life experience and adult oxytocin system functioning, but...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Lapp HE,Bartlett AA,Zup SL,Hunter RG,Moore CL

    更新日期:2020-11-01 00:00:00

  • Rapid effects of corticosterone on cache recovery in mountain chickadees (Parus gambeli).

    abstract::Environmental perturbations increase adrenal activity in several vertebrates. Increases in corticosterone may serve as a proximate trigger whereby organisms can rapidly adapt their behavior to survive environmental fluctuations. In food-caching songbirds, inclement weather may present the need to alter caching and/or ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Saldanha CJ,Schlinger BA,Clayton NS

    更新日期:2000-03-01 00:00:00

  • Neuropeptidergic regulation of affiliative behavior and social bonding in animals.

    abstract::Social relationships are essential for maintaining human mental health, yet little is known about the brain mechanisms involved in the development and maintenance of social bonds. Animal models are powerful tools for investigating the neurobiological mechanisms regulating the cognitive processes leading to the develop...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审


    authors: Lim MM,Young LJ

    更新日期:2006-11-01 00:00:00

  • Effects of estradiol in adult neurogenesis and brain repair in zebrafish.

    abstract::The brain of the adult teleost fish exhibits intense neurogenic activity and an outstanding capability for brain repair. Remarkably, the brain estrogen-synthesizing enzyme, aromatase B, is strongly expressed, particularly in adult fishes, in radial glial cells, which act as progenitors. Using zebrafish, we tested the ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Diotel N,Vaillant C,Gabbero C,Mironov S,Fostier A,Gueguen MM,Anglade I,Kah O,Pellegrini E

    更新日期:2013-02-01 00:00:00