Estrogen treatment during development alters adult partner preference and reproductive behavior in female laboratory rats.

Abstract:

:There is broad acceptance for the idea that during development estradiol 'organizes' many aspects of reproductive behavior including partner preferences in the laboratory rat. With respect to partner preference, this idea is drawn from studies where estrogen action was in someway blocked, either through aromatase or estrogen receptor inhibition, during development in male rats. The lack of estrogens neonatally results in a decrease in the male rat's preference for females. In this study, the effect of early postnatal estradiol treatment on the partner preferences of female rats was examined as a further test of the hypothesis that male-typical partner preference is dependent upon early exposure to estrogens. Our principal finding was that increased postnatal estradiol exposure during development affected partner preference in the expected direction, and this effect was seen under several adult hormonal and behavioral testing conditions. Female rats that received exogenous estradiol during development spent more time with an estrous female and less time with a sexually active male than did cholesterol treated females. The estradiol treatment also disrupted normal female sexual behavior, receptivity, and proceptivity.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Henley CL,Nunez AA,Clemens LG

doi

10.1016/j.yhbeh.2008.08.009

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

68-75

issue

1

eissn

0018-506X

issn

1095-6867

pii

S0018-506X(08)00255-9

journal_volume

55

pub_type

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