Androgen regulation of axon growth and neurite extension in motoneurons.

Abstract:

:Androgens act on the CNS to affect motor function through interaction with a widespread distribution of intracellular androgen receptors (AR). This review highlights our work on androgens and process outgrowth in motoneurons, both in vitro and in vivo. The actions of androgens on motoneurons involve the generation of novel neuronal interactions that are mediated by the induction of androgen-dependent neurite or axonal outgrowth. Here, we summarize the experimental evidence for the androgenic regulation of the extension and regeneration of motoneuron neurites in vitro using cultured immortalized motoneurons, and axons in vivo using the hamster facial nerve crush paradigm. We place particular emphasis on the relevance of these effects to SBMA and peripheral nerve injuries.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Fargo KN,Galbiati M,Foecking EM,Poletti A,Jones KJ

doi

10.1016/j.yhbeh.2008.01.014

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

716-28

issue

5

eissn

0018-506X

issn

1095-6867

pii

S0018-506X(08)00025-1

journal_volume

53

pub_type

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