Hippocampal anatomy and water maze performance are affected by neonatal cryoanesthesia in rats of both sexes.

Abstract:

:There is recent evidence that cryoanesthesia, commonly used during neonatal hormone manipulations (e.g., gonadectomy), has deleterious effects on the morphology of the splenium of the corpus callosum and primary visual cortex in adult rats of both sexes. (Nuñez and Juraska, 1998; Nuñez, Kim, and Juraska, 1998). In the present study, the effect of neonatal cryoanesthesia on the morphology of the hippocampus and dentate gyrus and on performance in the Morris water maze was investigated. Cold exposure for as brief as 30 min (5 degrees C) on Postnatal Day 1 resulted in a significant decrease in the volume of the hippocampus and in brain weight of adults. Performance on the water maze was also impaired in cold-exposed animals. This study indicates that not only morphology but also behavioral performance in adulthood are affected by neonatal cryoanesthesia.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Nuñez JL,Koss WA,Juraska JM

doi

10.1006/hbeh.2000.1572

keywords:

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

169-78

issue

3

eissn

0018-506X

issn

1095-6867

pii

S0018-506X(00)91572-1

journal_volume

37

pub_type

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