Genotype modulates the aggression-promoting quality of progesterone in pregnant mice.

Abstract:

:During late pregnancy, female mice of the DBA/2J inbred strain are more likely to exhibit aggressive behavior toward a standard stimulus intruder male than C57BL/6J females. This strain difference can not be accounted for by differences in circulating levels of progesterone (P) since pregnant DBA/2J and C57BL/6J females exhibit similar patterns of the steroid throughout pregnancy. Upon receiving subcutaneously implanted Silastic capsules containing P, virgin DBA/2J mice are more likely than virgin C57BL/6J to respond to the steroid by exhibiting aggression. Strain differences in the aggressive behavior exhibited by pregnant mice may be related to genotype-based variation in central neural tissue sensitivity to P.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Svare B

doi

10.1016/0018-506x(88)90033-5

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

90-9

issue

1

eissn

0018-506X

issn

1095-6867

pii

0018-506X(88)90033-5

journal_volume

22

pub_type

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