Abstract：
:We examined effects of a wide range of doses of three man-made estrogenic chemicals during fetal life on neurobehavioral changes during early postnatal life in mice. Pregnant mice were fed a 4-log range of o,p'DDT, methoxychlor (MXC), and the drug diethystilbestrol (DES) from gestation days 11 to 17. Offspring were examined for changes in postnatal growth and the development of neuromuscular reflexes. Fetal exposure to the estrogenic chemicals altered the number of live pups per litter, the sex ratio of the litters, the anogenital distance of male and female offspring at birth (a bioassay for fetal androgen action), and the body weight of offspring at birth and during the first 5 days of postnatal life. In most cases, however, the dose-response relationships were complex (non-monotonic), with effects at the highest dose examined being opposite to effects seen at lower doses. The two markers of neurobehavioral development, righting and cliff avoidance reflexes, were not sensitive indicators of prenatal estrogen exposure. Only maternal exposure to the lowest MXC dose produced an increase in reactivity in righting and cliff avoidance tests in offspring.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Palanza P,Parmigiani S,vom Saal FSdoi
10.1006/hbeh.2001.1697keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
252-65issue
2eissn
0018-506Xissn
1095-6867pii
S0018-506X(01)91697-6journal_volume
40pub_type
杂志文章abstract：:Ovarian steroid hormones, estradiol and progesterone, regulate cellular functions in the central nervous system, resulting in the alterations in physiology and reproductive behavior. One means by which steroid hormones exert their neural effects on reproductive behavior is via their intracellular receptors functioning...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1006/hbeh.2001.1687
更新日期：2001-09-01 00:00:00
abstract：:Patients with thyroid dysfunction (31 hypothyroid, 32 subclinical hypothyroidism, 34 hyperthyroid, and 30 subclinical hyperthyroidism) and 37 euthyroid control subjects were recruited and performed the attention network test (ANT), which can simultaneously examine the alertness, orientation and execution control of th...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2020.104714
更新日期：2020-05-01 00:00:00
abstract：:In estradiol-primed nonreceptive ovariectomized rats, activation of G protein-coupled estrogen receptor 1 (GPER) in the arcuate nucleus of the hypothalamus (ARH) rapidly facilitates sexual receptivity (lordosis). Estradiol priming activates ARH β-endorphin (β-END) neurons that then activate medial preoptic (MPN) μ-opi...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.04.004
更新日期：2019-06-01 00:00:00
abstract：:When animals are under stress, glucocorticoids commonly inhibit adult neurogenesis by acting through glucocorticoid receptors (GRs). However, in some cases, conditions that elevate glucocorticoids promote adult neurogenesis, and the role of glucocorticoid receptors in these circumstances is not well understood. We exa...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.06.001
更新日期：2011-08-01 00:00:00
abstract：:The precise impact of age-related changes in hormone levels on cognition in men is still unclear due to differing study designs and contradictory findings. This study was undertaken to examine the relationship between endogenous sex hormone levels and cognitive functioning in healthy older men using a comprehensive ba...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2010.01.004
更新日期：2010-03-01 00:00:00
abstract：:Primates maintain a variety of social relationships and these can have fitness consequences. Research has established that different types of social relationships are unpinned by different or interacting hormonal systems, for example, the neuropeptide oxytocin influences social bonding, the steroid hormone testosteron...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2017.03.004
更新日期：2017-05-01 00:00:00
abstract：:The human face displays a wealth of information, including information about dominance and fecundity. Dominance and fecundity are also associated with lower concentrations of the stress hormone cortisol, suggesting that cortisol may negatively predict facial dominance and attractiveness. We digitally photographed 61 w...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2015.03.006
更新日期：2015-05-01 00:00:00
abstract：:Social relationships among spouses, family members, and friends are known to affect physical and mental health. In particular, long-lasting bonds between socio-sexual partners have profound effects on cognitive, social, emotional, and physical well-being. We have previously reported that pair bonding in monogamous pra...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2020.104685
更新日期：2020-04-01 00:00:00
abstract：:The time of day at which mating occurs is dramatically different in diurnal compared to nocturnal rodents. We used a diurnal murid rodent, Arvicanthis niloticus, to determine if inverted rhythms in responsiveness to hormones contribute to this difference. Male and hormone-primed female grass rats were tested for matin...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2004.07.006
更新日期：2005-01-01 00:00:00
abstract：:The hormonal control of territorial aggression in male and female vertebrates outside the breeding season is still unresolved. Most vertebrates have regressed gonads when not breeding and do not secrete high levels of sex steroids. However, recent studies implicate estrogens in the regulation of non-breeding territori...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2003.08.002
更新日期：2004-01-01 00:00:00
abstract：:Seasonal brain plasticity contributes to a variety of physiological and behavioral processes. We hypothesized that variations in GnRH expression and cell proliferation facilitated seasonal breeding and food hoarding. Here, we reported seasonal changes in sexual and social behavior, GnRH expression and brain cell proli...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.03.003
更新日期：2019-06-01 00:00:00
abstract：:Previous tract-tracing studies demonstrated the existence of projections from the medial preoptic nucleus (POM) to the mesencephalic central gray (GCt) in quail. GCt contains a significant number of aromatase-immunoreactive (ARO-ir) fibers and punctate structures, but no ARO-ir cells are present in this region. The or...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.2001.1702
更新日期：2001-11-01 00:00:00
abstract：:In previous studies, we showed for the first time that prenatal stress in rats produces long-term alterations of formalin-induced pain behavior that are dependent on age and sex, and we demonstrated an important role of the serotonergic system in mechanisms of prenatal stress (Butkevich, I.P. and Vershinina, E.A., 200...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2008.09.008
更新日期：2009-01-01 00:00:00
abstract：:Monoaminergic systems are important modulators of the neuroendocrine, autonomic, and behavioral responses to stress-related stimuli. The male roughskin newt (Taricha granulosa) was used as a model system to investigate the effects of corticotropin-releasing factor (CRF) or corticosterone administration on tissue conce...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.2001.1646
更新日期：2001-05-01 00:00:00
abstract：:Previous studies have found a clear relationship between prolactin (prl) and paternal care in various vertebrate taxa. In New World monkeys, it has been demonstrated in several species that fathers have high prolactin levels even during periods without infant rearing. In this study, we followed the reproductive career...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2004.04.010
更新日期：2004-12-01 00:00:00
abstract：:Stress during pregnancy and the postpartum can influence the well-being of both the mother and her offspring. Prolonged elevated levels of glucocorticoids are associated with depression and we developed an animal model of postpartum depression/stress based on high levels of corticosterone (CORT) during the postpartum....
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2010.07.012
更新日期：2010-11-01 00:00:00
abstract：:From an evolutionary point of view, female sexual desire contributes greatly to the success of reproduction by coordinating sexual behavior. It is known that female sexual desire fluctuates with the menstrual cycle. However, little is known about the role of basic emotions during menstrual cycle. We designed a facial ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2008.06.007
更新日期：2009-02-01 00:00:00
abstract：:Social behavior plays a significant role in the formation of social structure and population regulation in both animals and humans. Oxytocin (OXT) and its receptor (OXTR) are well known for regulating social behaviors, but their upstream regulating factors are rarely investigated. We hypothesized that the phosphorylat...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.104638
更新日期：2020-03-01 00:00:00
abstract：:While it is generally accepted that social isolation has detrimental effects on social species, little is known about the importance of social interactions in less social species-particularly for wild reproductive females. We studied socially-flexible yellow-bellied marmots (Marmota flaviventer) and asked whether feat...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.104577
更新日期：2019-11-01 00:00:00
abstract：:Androgen levels show strong patterns throughout the year in male vertebrates and play an important role in the seasonal modulation of the frequency, intensity and persistence of aggression. The Challenge Hypothesis (Wingfield, J.C., Hegner, R.E., Dufty, A.M., Ball, G.F., 1990. The "Challenge Hypothesis": Theoretical i...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2007.01.007
更新日期：2007-04-01 00:00:00
abstract：:Though there are multiple routes through which parents can influence their offspring, recent studies of environmentally induced epigenetic variation have highlighted the role of non-genomic pathways. In addition to the experience-dependent modification of DNA methylation that can be achieved via mother-infant interact...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2010.06.018
更新日期：2011-03-01 00:00:00
abstract：:The behavioral and endocrine activation of sexual behaviors exhibited by male goats, especially self-enurination (SE), is poorly understood. In the first experiment, to assess the influence of socio-sexual context on SE in bucks, the effects of distance from does, the presence of estrous versus non-estrous does and th...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.01.008
更新日期：2019-03-01 00:00:00
abstract：:Among the suite of seasonal adaptations displayed by nontropical rodents, some species demonstrate increased territorial aggression in short compared with long day lengths despite basal levels of testosterone. The precise physiological mechanisms mediating seasonal changes in aggression, however, remain largely unknow...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2004.07.001
更新日期：2004-12-01 00:00:00
abstract：:Previous studies in our laboratory have shown that estradiol and progesterone affect beta-endorphin and Met-enkephalin levels in specific brain regions and that these effects are diurnally controlled. The present investigation was conducted to evaluate the effects of estradiol and progesterone on pain latency and brai...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1996.0029
更新日期：1996-09-01 00:00:00
abstract：:Recent studies have reported that oxytocin ameliorates behavioral abnormalities in both animal models and individuals with autism spectrum disorders (ASD). However, the mechanisms underlying the ameliorating effects of oxytocin remain unclear. In this study, we examined the effects of intranasal oxytocin on impairment...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2017.09.013
更新日期：2017-11-01 00:00:00
abstract：:The neuropeptide Oxytocin (OT) has been implicated in many aspects of mammalian social behavior. This study investigates how OT interacts with two well-studied determinants of cooperative behavior: incentives and social information. Participants received OT or a placebo and played two economic games: a Coordination Ga...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2010.01.006
更新日期：2010-03-01 00:00:00
abstract：:Nitric oxide (NO) has been suggested to play a crucial role in the regulation of lordosis behavior via stimulation of guanylyl cyclase to synthesize cyclic GMP. Whalen and Lauber (1986, Neurosci. Biobehav. Rev. 10, 47-53) hypothesized that hormones and pharmacological agents known to facilitate lordosis in estrogen-pr...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1997.1413
更新日期：1997-10-01 00:00:00
abstract：:Species with alternative reproductive tacts are good models to investigate the poorly understood question of whether individual variation within sexes results from the same physiological mechanisms that control variation between sexes. We have shown previously that adult male tree lizards, Urosaurus ornatus, of differ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(92)90023-o
更新日期：1992-12-01 00:00:00
abstract：:Most seasonally breeding songbirds display dramatic seasonal fluctuations in plasma testosterone (T) levels and mate attraction behaviors, including song. However, males of some songbird species, such as the European starling (Sturnus vulgaris), continue to sing at high levels after the breeding season, when T levels ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.2002.1824
更新日期：2002-11-01 00:00:00
abstract：:Animal studies indicate that sex hormones have widespread effects on the brain, cognition and emotion, but findings in humans are inconsistent. Well-controlled studies in nonhuman primates are crucial to resolve these discrepancies. In this study, we examined the effects of testosterone (T) on emotion in male rhesus m...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2010.08.010
更新日期：2010-11-01 00:00:00
