Altered attention networks in patients with thyroid dysfunction: A neuropsychological study.


:Patients with thyroid dysfunction (31 hypothyroid, 32 subclinical hypothyroidism, 34 hyperthyroid, and 30 subclinical hyperthyroidism) and 37 euthyroid control subjects were recruited and performed the attention network test (ANT), which can simultaneously examine the alertness, orientation and execution control of the participants. Patients with hypothyroidism had abnormalities in the alerting network, and those with hyperthyroidism had impairments of the alerting and executive control networks. No attention networks deficit existed in patients with subclinical hyperthyroidism and subclinical hypothyroidism. The anxiety and depression scores of patients with thyroid dysfunction were significantly higher than those of the healthy control group. Covariance analysis demonstrated that interactions between group and Hamilton Anxiety Scale scores, group and HAMD score were not significant, but there was a significant main effect for group when analyzing the difference in values of the alerting network between groups. Further, the efficiency of the executive control network was negatively correlated with the T4 level in the hypothyroidism group, and positively correlated with the T4 level in the hyperthyroidism group. T4 or T3 level and efficiencies of the executive control network had a significant quadratic U-shaped relationship in all participants. In summary, the patients with four kinds of thyroid dysfunction exhibited different characteristics of ANT performance. Patients with thyroid dysfunction had various degrees of anxiety and depression disorders, but anxiety and depression disorders had no effect on the differences in the executive control network between the groups.


Horm Behav


Hormones and behavior


Yuan L,Luan D,Xu X,Yang Q,Huang X,Zhao S,Zhang Y,Zhou Z




Has Abstract


2020-05-01 00:00:00












  • Corticosterone microinjected into nucleus pontis oralis increases tonic immobility in rats.

    abstract::Tonic immobility (TI) is also known as "immobility response", "immobility reflex", "animal hypnosis", etc. It is an innate antipredatory behavior characterized by an absence of movement, varying degrees of muscular activity, and a relative unresponsiveness to external stimuli. Experimentally, TI is commonly produced b...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Sandoval-Herrera V,Trujillo-Ferrara JG,Miranda-Páez A,De La Cruz F,Zamudio SR

    更新日期:2011-09-01 00:00:00

  • Effects of environmental stress on mRNA and protein expression levels of steroid 5alpha-Reductase isozymes in adult rat brain.

    abstract::Environmental stress conditions are important factors in human health and should be considered in the development of appropriate health policies, since they have been associated with psychological disorders and even with death. A link between stress and changes in 3alpha,5alpha-reduced neurosteroids has been reported....

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Sánchez P,Torres JM,Olmo A,O'Valle F,Ortega E

    更新日期:2009-09-01 00:00:00

  • The effects of exogenous 11-ketotestosterone, testosterone, and cyproterone acetate on prespawning and parental care behaviors of male bluegill.

    abstract::This study investigated the effect of exogenous 11-ketotestosterone (11KT) and testosterone (T), two important androgens involved in fish reproduction, as well as cyproterone acetate (CYA), an antiandrogen, on behaviors of male bluegill (Lepomis macrochirus) during prespawning and parental care periods. Parental male ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Kindler PM,Bahr JM,Philipp DP

    更新日期:1991-09-01 00:00:00

  • Reproductive experience differentially affects spatial reference and working memory performance in the mother.

    abstract::The transition to motherhood results in a number of hormonal, neurological, and behavioral changes necessary to ensure offspring survival. Once motherhood is established, further neurological and behavioral changes may result with additional parity and mothering. Recent research has shown that motherhood enhances both...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Pawluski JL,Walker SK,Galea LA

    更新日期:2006-02-01 00:00:00

  • Gender change from female to male in classical congenital adrenal hyperplasia.

    abstract::The psychoendocrinology of the development of normal gender identity and its variations is poorly understood. Studies of gender development in individuals born with endocrinologically well-characterized intersex conditions are heuristically valuable for the disaggregation of factors that are acting in concert during n...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Meyer-Bahlburg HF,Gruen RS,New MI,Bell JJ,Morishima A,Shimshi M,Bueno Y,Vargas I,Baker SW

    更新日期:1996-12-01 00:00:00

  • Does access to the bluestreak cleaner wrasse Labroides dimidiatus affect indicators of stress and health in resident reef fishes in the Red Sea?

    abstract::Interactions between the bluestreak cleaner wrasse Labroides dimidiatus and its client reef fish are a textbook example of interspecific mutualism. The fact that clients actively visit cleaners and invite inspection, together with evidence that cleaners eat many client ectoparasites per day, indeed strongly suggests a...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Ros AF,Lusa J,Meyer M,Soares M,Oliveira RF,Brossard M,Bshary R

    更新日期:2011-01-01 00:00:00

  • Testosterone levels and evoked vocal responses in a natural population of the frog Batrachyla taeniata.

    abstract::Relationships between testosterone plasma levels and evoked vocal responses of males of the leptodactylid frog Batrachyla taeniata from southern Chile were studied. Evoked vocal responses were elicited in the field with playbacks of a synthetic imitation of the conspecific advertisement call and variants of this signa...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Solís R,Penna M

    更新日期:1997-04-01 00:00:00

  • Localized and discrete changes in neuropeptide (LHRH and TRH) and neurotransmitter (NE and DA) concentrations within the olfactory bulbs of male mice as a function of social interaction.

    abstract::Individually housed male mice were exposed to either an intact male or an ovariectomized female mouse for 1 min and decapitated at 5, 15, or 60 min to examine the hypothesis whether discrete changes in olfactory bulb neuropeptide (LHRH and TRH) and neurotransmitter (NE and DA) concentrations would occur following onse...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Dluzen DE,Ramirez VD

    更新日期:1983-06-01 00:00:00

  • Oxytocin and cooperation under conditions of uncertainty: the modulating role of incentives and social information.

    abstract::The neuropeptide Oxytocin (OT) has been implicated in many aspects of mammalian social behavior. This study investigates how OT interacts with two well-studied determinants of cooperative behavior: incentives and social information. Participants received OT or a placebo and played two economic games: a Coordination Ga...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Declerck CH,Boone C,Kiyonari T

    更新日期:2010-03-01 00:00:00

  • Progesterone reduces the effect of the serotonin 1B/1D receptor antagonist, GR 127935, on lordosis behavior.

    abstract::Ovariectomized rats were hormonally primed with 10 microg estradiol benzoate or with estradiol benzoate plus 500 microg progesterone. Rats received a bilateral infusion with 200 ng of the 5-HT(1B/1D) receptor antagonist, N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1-1'-b...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Uphouse L,Hiegel C,Guptarak J,Maswood N

    更新日期:2009-01-01 00:00:00

  • Gonadal hormones masculinize and defeminize reproductive behaviors during puberty in the male Syrian hamster.

    abstract::Three experiments were conducted to test whether testicular hormones secreted during puberty masculinize and defeminize the expression of adult reproductive behavior. Experiment 1 tested the hypothesis that gonadal hormones during puberty masculinize behavioral responses to testosterone (T) in adulthood. Male hamsters...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Schulz KM,Richardson HN,Zehr JL,Osetek AJ,Menard TA,Sisk CL

    更新日期:2004-04-01 00:00:00

  • Taurine modulates the stress response in zebrafish.

    abstract::The zebrafish (Danio rerio) is used as an emergent model organism to investigate the behavioral and physiological responses to stress. The anxiolytic-like effects of taurine in zebrafish support the existence of different mechanisms of action, which can play a role in preventing stress-related disorders (i.e., modulat...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Mezzomo NJ,Fontana BD,Müller TE,Duarte T,Quadros VA,Canzian J,Pompermaier A,Soares SM,Koakoski G,Loro VL,Rosemberg DB,Barcellos LJG

    更新日期:2019-03-01 00:00:00

  • GOAT induced ghrelin acylation regulates hedonic feeding.

    abstract::Ghrelin is an orexigenic hormone that regulates homeostatic and reward-related feeding behavior. Recent evidence indicates that acylation of ghrelin by the gut enzyme ghrelin O-acyl transferase (GOAT) is necessary to render ghrelin maximally active within its target tissues. Here we tested the hypothesis that GOAT act...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Davis JF,Perello M,Choi DL,Magrisso IJ,Kirchner H,Pfluger PT,Tschoep M,Zigman JM,Benoit SC

    更新日期:2012-11-01 00:00:00

  • Long-term continuous allopregnanolone elevation causes memory decline and hippocampus shrinkage, in female wild-type B6 mice.

    abstract::Chronic stress in various forms increases the risk for cognitive dysfunction, dementia and Alzheimer's disease. While the pathogenesis behind these findings is unknown, growing evidence suggests that chronic increase in neurosteroid levels, such as allopregnanolone, is part of the mechanism. We treated wild-type C57BL...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Bengtsson SK,Johansson M,Bäckström T

    更新日期:2016-02-01 00:00:00

  • Compatibility drives female preference and reproductive success in the monogamous California mouse (Peromyscus californicus) more strongly than male testosterone measures.

    abstract::Female assessment of male attractiveness and how preferred qualities impact reproductive success is central to the study of mate choice. Male attractiveness may depend on traits beneficial to the reproductive success (RS) of any female, termed 'universal quality', and/or on behavioral and biological interactions betwe...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Gleason ED,Holschbach MA,Marler CA

    更新日期:2012-01-01 00:00:00

  • Testosterone therapy is associated with reduced tactile sensitivity in human males.

    abstract::Responses to vibrotactile stimuli were examined in men as a function of chronic exposure to either exogenous or endogenous androgens. Psychophysical techniques were used to evaluate thresholds to stimulus detection and perceived stimulus intensities in response to mild vibration applied to either the finger or the pen...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Burris AS,Gracely RH,Carter CS,Sherins RJ,Davidson JM

    更新日期:1991-06-01 00:00:00

  • Androgens enhance plasticity of an electric communication signal in female knifefish, Brachyhypopomus pinnicaudatus.

    abstract::Sex steroids were initially defined by their actions shaping sexually dimorphic behavioral patterns. More recently scientists have begun exploring the role of steroids in determining sex differences in behavioral plasticity. We investigated the role of androgens in potentiating circadian, pharmacological, and socially...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Allee SJ,Markham MR,Stoddard PK

    更新日期:2009-08-01 00:00:00

  • Light as a modulator of emotion and cognition: Lessons learned from studying a diurnal rodent.

    abstract::Light profoundly affects the behavior and physiology of almost all animals, including humans. One such effect in humans is that the level of illumination during the day positively contributes to affective well-being and cognitive function. However, the neural mechanisms underlying the effects of daytime light intensit...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审


    authors: Yan L,Lonstein JS,Nunez AA

    更新日期:2019-05-01 00:00:00

  • Developmental plasticity of HPA and fear responses in rats: a critical review of the maternal mediation hypothesis.

    abstract::Developmental plasticity of HPA and fear responses in rats has been proposed to be mediated by environment-dependent variation in active maternal care. Here, we review this maternal mediation hypothesis based on the postnatal manipulation literature and on our own recent research in rats. We show that developmental pl...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审


    authors: Macrì S,Würbel H

    更新日期:2006-12-01 00:00:00

  • The influence of androgenic and estrogenic hormones on sexual behavior in castrated adult male pigs.

    abstract::The objectives of these studies were to evaluate the influence of testosterone propionate (TP), estradiol cypionate (EC), dihydrotestosterone propionate (DHTP), EC + TP, EC + DHTP, and TP + DHTP on traits of masculine sexual behavior in castrated adult male pigs of different breeds. Masculine sexual behavior was resto...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Levis DG,Ford JJ

    更新日期:1989-09-01 00:00:00

  • Sex differences in cortisol's regulation of affiliative behavior.

    abstract::A contribution to a special issue on Hormones and Human Competition. A stress perspective is used to illuminate how competitive defeat and victory shape biology and behavior. We report a field study examining how change in cortisol following perceived defeat (vs. victory) in a competition-in this case, a dog agility c...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Sherman GD,Rice LK,Jin ES,Jones AC,Josephs RA

    更新日期:2017-06-01 00:00:00

  • Seasonal and social correlates of fecal testosterone and cortisol levels in wild male muriquis (Brachyteles arachnoides).

    abstract::Fecal testosterone and cortisol levels were analyzed from six wild male muriquis (Brachyteles arachnoides) over a 19-month period at the Estação Biológica de Caratinga in Minas Gerais, Brazil, to investigate the hormonal correlates of seasonal sexual behavior and environmental conditions. Group mean testosterone level...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Strier KB,Ziegler TE,Wittwer DJ

    更新日期:1999-04-01 00:00:00

  • Effects of neonatal testosterone treatment on pacing behaviors and development of a conditioned place preference.

    abstract::Two experiments assessed the effects of neonatal testosterone treatment on paced mating behavior and conditioned place preference in female rats. In both experiments, females received s.c. injections of 5.0 microg testosterone propionate or oil vehicle at three days postpartum. As adults, females were ovariectomized a...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Gans S,Erskine MS

    更新日期:2003-11-01 00:00:00

  • Fitness and behavioral correlates of pre-stress and stress-induced plasma cortisol titers in pink salmon (Oncorhynchus gorbuscha) upon arrival at spawning grounds.

    abstract::Semelparous Pacific salmon (Onchorynchus spp.) serve as an excellent model for examining the relationships between life history, behavior and individual variation in glucocorticoid (GC) stress hormone levels because reproductive behaviors are highly variable between individuals and failure to reproduce results in zero...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Cook KV,McConnachie SH,Gilmour KM,Hinch SG,Cooke SJ

    更新日期:2011-11-01 00:00:00

  • The role of vocal self-stimulation in female responses to males: implications for state-reading.

    abstract::As research neurobiologists, we pursue specific questions, and the answers rendered are also correspondingly specific. Our goal, however, is to understand an entire system or the whole organism. To that end, it is not only useful, but sometimes also necessary, that we periodically reappraise a body of specific data in...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审


    authors: Cheng MF

    更新日期:2008-01-01 00:00:00

  • Effects of long-term treatment with 17 beta-estradiol and medroxyprogesterone acetate on water maze performance in middle aged female rats.

    abstract::Although previous research has indicated that hormone replacement therapy benefits memory in menopausal women, several recent studies have shown either detrimental or no effects of treatment. These inconsistencies emphasize the need to evaluate the role of ovarian hormones in protecting against age-related cognitive d...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Lowry NC,Pardon LP,Yates MA,Juraska JM

    更新日期:2010-07-01 00:00:00

  • Ligand-independent activation of progestin receptors in sexual receptivity.

    abstract::Ovarian steroid hormones, estradiol and progesterone, regulate cellular functions in the central nervous system, resulting in the alterations in physiology and reproductive behavior. One means by which steroid hormones exert their neural effects on reproductive behavior is via their intracellular receptors functioning...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审


    authors: Mani S

    更新日期:2001-09-01 00:00:00

  • Aggressive encounters differentially affect serum dehydroepiandrosterone and testosterone concentrations in male Siberian hamsters (Phodopus sungorus).

    abstract::The gonadal hormone testosterone (T) regulates aggression across a wide range of vertebrate species. Recent evidence suggests that the adrenal prohormone dehydroepiandrosterone (DHEA) may also play an important role in regulating aggression. DHEA can be converted into active sex steroids, such as T and estradiol (E(2)...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Scotti MA,Schmidt KL,Newman AE,Bonu T,Soma KK,Demas GE

    更新日期:2009-10-01 00:00:00

  • High self-perceived stress and many stressors, but normal diurnal cortisol rhythm, in adults with ADHD (attention-deficit/hyperactivity disorder).

    abstract::Attention-deficit/hyperactivity disorder (ADHD) in adults is associated with significant impairment in many life activities and may thus increase the risk of chronic stress in everyday life. We compared adults with a DSM-IV ADHD diagnosis (n=28) with healthy controls (n=28) regarding subjective stress and amounts of s...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Hirvikoski T,Lindholm T,Nordenström A,Nordström AL,Lajic S

    更新日期:2009-03-01 00:00:00

  • Context-dependent effects of castration and testosterone treatment on song in male European starlings.

    abstract::Most seasonally breeding songbirds display dramatic seasonal fluctuations in plasma testosterone (T) levels and mate attraction behaviors, including song. However, males of some songbird species, such as the European starling (Sturnus vulgaris), continue to sing at high levels after the breeding season, when T levels ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章


    authors: Pinxten R,De Ridder E,Balthazart J,Eens M

    更新日期:2002-11-01 00:00:00