Effects of ovariectomy and estrogen treatment on learning and hippocampal neurotransmitters in mice.

Abstract:

:This study examined the effects of long-term estrogen treatment (sc 17 beta-estradiol minipellets) on learning in C57BL/6J female and male mice using a position discrimination task in the T-maze and a win-stay task (1/8 arms baited) in the radial arm maze (RAM). In addition, hippocampal monoamines and ChAT activity were measured at the end of the study and correlated to task performance. Female sham-operated (gonadally intact) and ovariectomized (OVX) mice were treated with estrogen either for 7 or 40 days before the behavioral tests and intact male mice for 7 days before the behavioral tests. In sham-operated mice the 40-day estrogen treatment improved RAM performance and in OVX mice both the 7- and 40-day estrogen treatments improved the performance in both maze tasks. The estrogen treatment also improved RAM performance in males. The hippocampal ChAT, NA, 5-HIAA, and DOPAC levels were decreased in OVX mice. Furthermore, the effects of estrogen treatment on the levels of hippocampal 5-HT and its metabolite 5-HIAA were different in sham-operated than in OVX mice. We could find no correlation between cognitive measures and neurochemical variables. This study gives new information about the effects of estrogen on learning and hippocampal neurotransmitters in mice.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Heikkinen T,Puoliväli J,Liu L,Rissanen A,Tanila H

doi

10.1006/hbeh.2001.1738

keywords:

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

22-32

issue

1

eissn

0018-506X

issn

1095-6867

pii

S0018506X01917386

journal_volume

41

pub_type

杂志文章
  • Chemical structure of corticosteroids and its relationship with their acute induction of lordosis in the female rat.

    abstract::The intravenous injection of several corticosteroids in the spayed estrogen-primed rat resulted, 5 min later, in a remarkable induction of lordosis response for deoxycorticosterone and 11-deoxycortisol. A lower but important effect was induced with corticosterone and 17 alpha-hydroxyprogesterone. A chemical structure-...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/0018-506x(90)90033-t

    authors: Kubli-Garfias C

    更新日期:1990-12-01 00:00:00

  • Behavioral depression: opposite effects of neonatal dexamethasone and ACTH-(4-9) analogue (ORG 2766) treatments in the rat.

    abstract::Permanent changes in novelty-induced arousal and behavioral depression were studied in adult male Wistar rats having received sc injections of 1 micrograms/g body wt dexamethasone (DEX) or ACTH-(4-9) analogue (ORG 2766), or the combined treatment of these substances at Postnatal Days 1, 3, and 5. Treatment with DEX in...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.1993.1028

    authors: Felszeghy K,Sasvári M,Nyakas C

    更新日期:1993-09-01 00:00:00

  • Commitment to relationships and preferences for femininity and apparent health in faces are strongest on days of the menstrual cycle when progesterone level is high.

    abstract::Previous studies of changes in women's behavior during the menstrual cycle have offered insight into the motivations underpinning women's preferences for social cues associated with possible direct benefits (e.g., investment, low risk of infection) and indirect benefits (e.g., offspring viability). Here we sought to e...

    journal_title:Hormones and behavior

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.yhbeh.2005.03.010

    authors: Jones BC,Little AC,Boothroyd L,Debruine LM,Feinberg DR,Smith MJ,Cornwell RE,Moore FR,Perrett DI

    更新日期:2005-09-01 00:00:00

  • Developmental exposure to environmental estrogens alters anxiety and spatial memory in female mice.

    abstract::Humans and wildlife are exposed to numerous anthropogenic drugs and pollutants. Many of these compounds are hormonally active, and recent evidence suggests that the presence of these endocrine disruptors permanently alters normal development and physiology in a variety of vertebrate species. Here, we report on the eff...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2006.01.007

    authors: Ryan BC,Vandenbergh JG

    更新日期:2006-06-01 00:00:00

  • The perfume of reproduction in birds: chemosignaling in avian social life.

    abstract::This article is part of a Special Issue "Chemosignals and Reproduction". Chemical cues were probably the first cues ever used to communicate and are still ubiquitous among living organisms. Birds have long been considered an exception: it was believed that birds were anosmic and relied on their acute visual and acoust...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.yhbeh.2014.06.001

    authors: Caro SP,Balthazart J,Bonadonna F

    更新日期:2015-02-01 00:00:00

  • GnRH expression and cell proliferation are associated with seasonal breeding and food hoarding in Mongolian gerbils (Meriones unguiculatus).

    abstract::Seasonal brain plasticity contributes to a variety of physiological and behavioral processes. We hypothesized that variations in GnRH expression and cell proliferation facilitated seasonal breeding and food hoarding. Here, we reported seasonal changes in sexual and social behavior, GnRH expression and brain cell proli...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2019.03.003

    authors: Yao W,Liu W,Deng K,Wang Z,Wang DH,Zhang XY

    更新日期:2019-06-01 00:00:00

  • Sexually dimorphic role of G protein-coupled estrogen receptor (GPER) in modulating energy homeostasis.

    abstract::This article is part of a Special Issue "Energy Balance". The classical estrogen receptors, estrogen receptor-α and estrogen receptor-β are well established in the regulation of body weight and energy homeostasis in both male and female mice, whereas, the role for G protein-coupled estrogen receptor 1 (GPER) as a modu...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2014.02.004

    authors: Davis KE,Carstens EJ,Irani BG,Gent LM,Hahner LM,Clegg DJ

    更新日期:2014-06-01 00:00:00

  • Activation of androgen receptors protects intact male mice from memory impairments caused by aromatase inhibition.

    abstract::Although 17β-estradiol (E2) is known to regulate hippocampal function, the specific contributions of hippocampally-synthesized E2 remain unclear. Infusion of the aromatase inhibitor letrozole into the dorsal hippocampus (DH) of ovariectomized mice disrupts object recognition and object placement memory consolidation, ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2019.01.002

    authors: Koss WA,Frick KM

    更新日期:2019-05-01 00:00:00

  • Attractivity of male and female rats which are hormonally manipulated during early development and in adulthood.

    abstract::Attractivity is one aspect of female sexuality relevant for the understanding of male-female sexual interactions. In a previous study, it was shown that intact males were equally attracted to early androgenized, gonadally intact females as to normally developed, estrous females. The present study was designed to inves...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/0018-506x(86)90001-2

    authors: de Jonge FH,Meyerson BJ,van de Poll NE

    更新日期:1986-12-01 00:00:00

  • Palatable food reduces anxiety-like behaviors and HPA axis responses to stress in female rats in an estrous-cycle specific manner.

    abstract::Eating tasty foods dampens responses to stress - an idea reflected in the colloquial term 'comfort foods'. To study the neurobiological mechanisms by which palatable foods provide stress relief, we previously characterized a limited sucrose intake (LSI) paradigm in which male rats are given twice-daily access to 4 ml ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2019.07.005

    authors: Egan AE,Seemiller LR,Packard AEB,Solomon MB,Ulrich-Lai YM

    更新日期:2019-09-01 00:00:00

  • Effects of neonatal testosterone treatment on pacing behaviors and development of a conditioned place preference.

    abstract::Two experiments assessed the effects of neonatal testosterone treatment on paced mating behavior and conditioned place preference in female rats. In both experiments, females received s.c. injections of 5.0 microg testosterone propionate or oil vehicle at three days postpartum. As adults, females were ovariectomized a...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/s0018-506x(03)00157-0

    authors: Gans S,Erskine MS

    更新日期:2003-11-01 00:00:00

  • Genotype modulates the aggression-promoting quality of progesterone in pregnant mice.

    abstract::During late pregnancy, female mice of the DBA/2J inbred strain are more likely to exhibit aggressive behavior toward a standard stimulus intruder male than C57BL/6J females. This strain difference can not be accounted for by differences in circulating levels of progesterone (P) since pregnant DBA/2J and C57BL/6J femal...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/0018-506x(88)90033-5

    authors: Svare B

    更新日期:1988-03-01 00:00:00

  • Effect of photoperiod on vasopressin-induced aggression in Syrian hamsters.

    abstract::Syrian hamsters are photoperiodic and become sexually quiescent when exposed to short "winter-like" photoperiods. In short photoperiods, male hamsters display significantly higher levels of aggression than males housed in long photoperiods. Arginine-vasopressin (AVP) within the anterior hypothalamus (AH) has been repo...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2004.04.006

    authors: Caldwell HK,Albers HE

    更新日期:2004-11-01 00:00:00

  • Nesting behavior is associated with VIP expression and VIP-Fos colocalization in a network-wide manner.

    abstract::Many species, including humans, engage in a series of behaviors that are preparatory to the arrival of offspring. Such "nesting behaviors" are of obvious importance, but relevant neuroendocrine mechanisms remain little studied. We here focus on the potential roles of vasoactive intestinal polypeptide (VIP) in the perf...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2014.12.010

    authors: Kingsbury MA,Jan N,Klatt JD,Goodson JL

    更新日期:2015-03-01 00:00:00

  • Seasonal and social correlates of fecal testosterone and cortisol levels in wild male muriquis (Brachyteles arachnoides).

    abstract::Fecal testosterone and cortisol levels were analyzed from six wild male muriquis (Brachyteles arachnoides) over a 19-month period at the Estação Biológica de Caratinga in Minas Gerais, Brazil, to investigate the hormonal correlates of seasonal sexual behavior and environmental conditions. Group mean testosterone level...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.1998.1505

    authors: Strier KB,Ziegler TE,Wittwer DJ

    更新日期:1999-04-01 00:00:00

  • Antenna contact and agonism in the male lobster cockroach, Nauphoeta cinerea.

    abstract::On any given day, about 35% of 80- to 85-day-old socially naïve male (SNM) lobster cockroaches (Nauphoeta cinerea) spontaneously adopted an aggressive posture (AP) without encountering another male [spontaneous AP (SAP)]. Although SAP SNMs showed significantly higher release of the pheromone 3-hydroxy-2-butanone (3H-2...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2007.04.013

    authors: Chou SY,Huang ZY,Chen SC,Yang RL,Kou R

    更新日期:2007-08-01 00:00:00

  • Biotic and abiotic sounds affect calling activity but not plasma testosterone levels in male frogs (Batrachyla taeniata) in the field and in captivity.

    abstract::In animals, the expression of diverse reproductive behaviors is hormonally regulated. In particular, vocalizing during courtship has been related to circulating androgen levels, and reciprocally, conspecific vocalizations are known to modulate androgen secretion in vertebrates. The effect of natural sounds of abiotic ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2019.104605

    authors: Muñoz MI,Quispe M,Maliqueo M,Penna M

    更新日期:2020-02-01 00:00:00

  • Hypothalamic grafts induce the recovery of lordosis in female hamsters with lesions of the ventromedial hypothalamus.

    abstract::Previous studies have documented the ability of neural grafts to stimulate the recovery of lordosis from neurochemical deficits. However, it was unclear if grafts also could reverse deficits in lordosis caused by lesions at critical points in the neural circuit controlling this response. To address this question, fema...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.1997.1421

    authors: Bartholomew MB,Floody OR

    更新日期:1997-12-01 00:00:00

  • Sex differences in salivary cortisol in response to acute stressors among healthy participants, in recreational or pathological gamblers, and in those with posttraumatic stress disorder.

    abstract::Sex differences in incidence and severity of some stress-related, neuropsychiatric disorders are often reported to favor men, suggesting that women may be more vulnerable to aberrant hypothalamic-pituitary-adrenal (HPA) axis responses to stress. In this review, we discuss several investigations that we, and others, ha...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.yhbeh.2009.06.003

    authors: Paris JJ,Franco C,Sodano R,Freidenberg B,Gordis E,Anderson DA,Forsyth JP,Wulfert E,Frye CA

    更新日期:2010-01-01 00:00:00

  • Low sexual desire in women: the role of reproductive hormones.

    abstract::The role of reproductive hormones in mediating sexual desire in healthy women is still unclear. Elucidation was sought in this study by comparing the hormonal milieu of two groups of subjects with markedly different levels of sexual desire. Seventeen women ages 27-39 who met DSM III-R criteria for severe, persistent, ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/0018-506x(89)90063-9

    authors: Schreiner-Engel P,Schiavi RC,White D,Ghizzani A

    更新日期:1989-06-01 00:00:00

  • Implication of galanin gene rs948854 polymorphism in depressive symptoms in adolescents.

    abstract::Genetic, social, and environmental conditions contribute to the development of depression, but the pathophysiological mechanisms are still unclear. Data accumulated in recent years provide significant evidence for a direct role of galanin (GAL). This study aimed to investigate the relation between SNPs in the galanine...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2017.10.001

    authors: da Conceição Machado F,de Souza LV,Rangel M,Jara ZP,do Carmo Franco M

    更新日期:2018-01-01 00:00:00

  • Elevated corticosterone levels elicit non-calling mating tactics in male toads independently of changes in circulating androgens.

    abstract::Competition among males for a limited number of females may result in the expression of condition-dependent alternative mating tactics. In such cases, decision rules mediating mating tactic expression are likely to be influenced by a male's external as well as internal environment. For example, experimental studies wi...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2005.09.004

    authors: Leary CJ,Garcia AM,Knapp R

    更新日期:2006-04-01 00:00:00

  • Dynamic regulation of brain aromatase and isotocin receptor gene expression depends on parenting status.

    abstract::Fathering behavior is critical for offspring survival in many species across diverse taxa, but our understanding of the neuroendocrine mechanisms regulating paternal care is limited in part because of the few primarily paternal species among the common animal models. However, many teleosts display primarily paternal c...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2018.06.006

    authors: DeAngelis R,Dodd L,Snyder A,Rhodes JS

    更新日期:2018-07-01 00:00:00

  • Effects of androgens and estrogens on sexual differentiation of sex behavior, scent marking, and the sexually dimorphic area of the gerbil hypothalamus.

    abstract::Mating, marking and the sexually dimorphic area (SDA) were studied in male gerbils that were castrated or sham-operated on the day of birth and in females given testosterone (T) propionate or oil 1 day later. Other females received dihydrotestosterone (DHT), R1881, estradiol benzoate (EB), R2858, DHT and EB, or DHT an...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.1996.0015

    authors: Ulibarri C,Yahr P

    更新日期:1996-06-01 00:00:00

  • Oxytocin receptor antagonist reverses the blunting effect of pair bonding on fear learning in monogamous prairie voles.

    abstract::Social relationships among spouses, family members, and friends are known to affect physical and mental health. In particular, long-lasting bonds between socio-sexual partners have profound effects on cognitive, social, emotional, and physical well-being. We have previously reported that pair bonding in monogamous pra...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2020.104685

    authors: Hirota Y,Arai A,Young LJ,Osako Y,Yuri K,Mitsui S

    更新日期:2020-04-01 00:00:00

  • Hippocampal anatomy and water maze performance are affected by neonatal cryoanesthesia in rats of both sexes.

    abstract::There is recent evidence that cryoanesthesia, commonly used during neonatal hormone manipulations (e.g., gonadectomy), has deleterious effects on the morphology of the splenium of the corpus callosum and primary visual cortex in adult rats of both sexes. (Nuñez and Juraska, 1998; Nuñez, Kim, and Juraska, 1998). In the...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.2000.1572

    authors: Nuñez JL,Koss WA,Juraska JM

    更新日期:2000-05-01 00:00:00

  • ESR1 polymorphisms, daily hassles, anger expression, and depressive symptoms in adolescent boys and girls.

    abstract::Studies reporting associations between genetic factors and mood-related traits have often been criticized (i) for failing to take into account the role of the social environment in which individuals act and (ii) for not maintaining a 'transparent narrative connection' between genes and outcomes. In a sample of adolesc...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2012.11.017

    authors: Vermeersch H,T'sjoen G,Kaufman JM,Van Houtte M

    更新日期:2013-03-01 00:00:00

  • Galanthamine plus estradiol treatment enhances cognitive performance in aged ovariectomized rats.

    abstract::We hypothesize that beneficial effects of estradiol on cognitive performance diminish with age and time following menopause due to a progressive decline in basal forebrain cholinergic function. This study tested whether galanthamine, a cholinesterase inhibitor used to treat memory impairment associated with Alzheimer'...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2011.08.010

    authors: Gibbs RB,Chipman AM,Hammond R,Nelson D

    更新日期:2011-11-01 00:00:00

  • Rapid effects of corticosterone on cache recovery in mountain chickadees (Parus gambeli).

    abstract::Environmental perturbations increase adrenal activity in several vertebrates. Increases in corticosterone may serve as a proximate trigger whereby organisms can rapidly adapt their behavior to survive environmental fluctuations. In food-caching songbirds, inclement weather may present the need to alter caching and/or ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.2000.1571

    authors: Saldanha CJ,Schlinger BA,Clayton NS

    更新日期:2000-03-01 00:00:00

  • Altered attention networks in patients with thyroid dysfunction: A neuropsychological study.

    abstract::Patients with thyroid dysfunction (31 hypothyroid, 32 subclinical hypothyroidism, 34 hyperthyroid, and 30 subclinical hyperthyroidism) and 37 euthyroid control subjects were recruited and performed the attention network test (ANT), which can simultaneously examine the alertness, orientation and execution control of th...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2020.104714

    authors: Yuan L,Luan D,Xu X,Yang Q,Huang X,Zhao S,Zhang Y,Zhou Z

    更新日期:2020-05-01 00:00:00