Abstract：
:Progesterone (P₄) and its metabolites, rapidly facilitate lordosis of rats partly through actions in the ventral tegmental area (VTA). The study of membrane progestin receptors (mPRs), of the Progestin and AdipoQ Receptor (PAQR) superfamily, has been limited to expression and regulation, instead of function. We hypothesized that if mPRs are required for progestin-facilitated lordosis in the VTA, then mPRs will be expressed in this region and knockdown will attenuate lordosis. First, expression of mPR was examined by reverse-transcriptase polymerase chain reaction (RT-PCR) in brain and peripheral tissues of proestrous Long-Evans rats. Expression of mPRα (paqr7) was observed in peripheral tissues and brain areas, including hypothalamus and midbrain. Expression of mPRβ (paqr8) was observed in brain tissues and was abundant in the midbrain and hypothalamus. Second, ovariectomized rats were estrogen (E₂; 0.09 mg/kg, SC), and P₄ (4 mg/kg, SC) or vehicle-primed, and infused with antisense oligodeoxynucleotides (AS-ODNs) targeted against mPRα and/or mPRβ intracerebroventricularly or to the VTA. Rats were assessed for motor (open field), anxiety (elevated plus maze), social (social interaction), and sexual (lordosis) behavior. P₄-facilitated lordosis was significantly reduced with administration of AS-ODNs for mPRα, mPRβ, or co-administration of mPRα and mPRβ to the lateral ventricle, compared to vehicle. P₄-facilitated lordosis was reduced, compared to vehicle, by administration of mPRβ AS-ODNs, or co-administration of mPRα and mPRβ AS-ODNs, but not mPRα AS-ODNs alone, to the VTA. No differences were observed for motor, anxiety, or social behaviors. Thus, mPRs in the VTA are targets of progestin-facilitated lordosis of rats.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Frye CA,Walf AA,Kohtz AS,Zhu Ydoi
10.1016/j.yhbeh.2013.05.012subject
Has Abstractpub_date
2013-08-01 00:00:00pages
539-45issue
3eissn
0018-506Xissn
1095-6867pii
S0018-506X(13)00124-4journal_volume
64pub_type
杂志文章abstract：:Like many teleosts, male bluegill sunfish (Lepomis macrochirus) provide sole parental care. To understand some of the proximate costs of parental care, we measured body condition and plasma levels of testosterone (T), 11-ketotestosterone (11KT) and cortisol in nesting bluegill males during pre-spawning, spawning and p...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2005.12.003
更新日期：2006-05-01 00:00:00
abstract：:The vertebrate hippocampus (HP) plays a critical role in the organization of memory. Estrogens alter synaptic morphology and function in the mammalian HP and may potentiate memory performance. Previous studies suggest that the songbird HP itself is a site of significant aromatase expression, intimating that local estr...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1998.1447
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2016.02.005
更新日期：2016-05-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2010.07.012
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1994.1011
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(88)90069-4
更新日期：1988-06-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2013.10.011
更新日期：2014-01-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2020.104867
更新日期：2020-11-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2017.10.012
更新日期：2018-01-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2003.09.012
更新日期：2004-03-01 00:00:00
abstract：:The hormonal control of territorial aggression in male and female vertebrates outside the breeding season is still unresolved. Most vertebrates have regressed gonads when not breeding and do not secrete high levels of sex steroids. However, recent studies implicate estrogens in the regulation of non-breeding territori...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2003.08.002
更新日期：2004-01-01 00:00:00
abstract：:Behavioral studies of an XY gonadal dysgenetic chacma baboon under estradiol benzoate treatment were carried out. The dysgenetic individual and two ovariectomized conspecific control females were given a total of three testing series. The dysgenetic individual showed progressive success in her sexual interactions with...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(84)90042-4
更新日期：1984-06-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2020.104869
更新日期：2020-11-01 00:00:00
abstract：:The role of reproductive hormones in mediating sexual desire in healthy women is still unclear. Elucidation was sought in this study by comparing the hormonal milieu of two groups of subjects with markedly different levels of sexual desire. Seventeen women ages 27-39 who met DSM III-R criteria for severe, persistent, ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(89)90063-9
更新日期：1989-06-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(91)90020-i
更新日期：1991-12-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(91)90038-j
更新日期：1991-03-01 00:00:00
abstract：:Consistent and heritable individual differences in reaction to challenges, often referred to as stress coping styles, have been extensively documented in vertebrates. In fish, selection for divergent post-stress plasma cortisol levels in rainbow trout (Oncorhynchus mykiss) has yielded a low (LR) and a high responsive ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2008.05.005
更新日期：2008-09-01 00:00:00
abstract：:Despite decades of laboratory research and clinical trials, a safe and effective treatment for traumatic brain injury (TBI) has yet to be put into successful clinical use. I suggest that much of the problem can be attributed to a reductionist perspective and attendant research strategy directed to finding or designing...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2012.05.004
更新日期：2013-02-01 00:00:00
abstract：:This work tested the hypothesis that gonadal steroid receptor activation was necessary for the restoration of several sociosexual behaviors (such as copulatory behavior, partner preference, 50-kHz vocalizations, and scent marking) in testosterone-treated gonadectomized male rats. Gonadal steroid receptors were blocked...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1998.1445
更新日期：1998-06-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.04.009
更新日期：2019-06-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2012.01.015
更新日期：2012-04-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1994.1039
更新日期：1994-12-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/s0018-506x(03)00119-3
更新日期：2003-08-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.07.019
更新日期：2011-11-01 00:00:00
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journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2015.06.016
更新日期：2015-07-01 00:00:00
abstract：:The behavioral and endocrine activation of sexual behaviors exhibited by male goats, especially self-enurination (SE), is poorly understood. In the first experiment, to assess the influence of socio-sexual context on SE in bucks, the effects of distance from does, the presence of estrous versus non-estrous does and th...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2019.01.008
更新日期：2019-03-01 00:00:00
abstract：:Women are at higher risk of anxiety and mood disorders, especially at transitions across the reproductive life cycle (premenstruum, postpartum, menopause). Premenstrual dysphoric disorder (PMDD) is one of female mood disorders associated with changing ovarian hormone levels. Because anxiety and depression frequently o...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2006.09.006
更新日期：2007-01-01 00:00:00
abstract：:Lizards provide a rich opportunity for investigating the mechanisms associated with arousal and the display of motivated behaviors. They exhibit diverse mating strategies and modes of conspecific communication. This review focuses on anole lizards, of which green anoles (Anolis carolinensis) have been most extensively...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2010.08.014
更新日期：2011-05-01 00:00:00
abstract：:Conspicuous sexual swellings in the females of some primate species have been a focus of scientific interest since Darwin first wrote about them in 1871. To understand these visual signals, research focused on exaggerated sexual swellings of Old World primates. However, some primate species develop much smaller sexual...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2006.10.008
更新日期：2007-02-01 00:00:00
abstract：:Intact male rats were tested on two successive weekly tests with females to determine their level of sexual activity. Nuclear estrogen receptor content was measured in specific brain regions of individual sexually responsive and sexually nonresponsive males. Sexually nonresponsive male rats had significantly reduced n...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(85)90022-4
更新日期：1985-06-01 00:00:00
