Studies on effects of tamoxifen (ICI 46474) on agonistic encounters between pairs of intact mice.

Abstract:

:The anti-estrogen tamoxifen (Tam), which has been shown to dramatically suppress offensive behavior in male rats without markedly influencing other aspects of the social encounter, was tested for its effectiveness in mice. TO strain albino mice were given control injections or 50 or 100 micrograms of Tam for 4 or 8 days. Subsequently, mice were tested in pairs (for a particular dose and treatment duration) in which both animals received Tam, one animal received Tam and one saline, or both animals received saline control injections. Ten-minute videotaped encounters were analyzed in terms of total times allocated to nonsocial investigation, social investigation, offense, defense, sexual activity/intense social investigation, and immobility. The lower dose given for the shorter duration produced less social investigation and more nonsocial investigation when Tam-treated subjects were paired together (cf. the Tam vs saline pairing). At all the other doses and durations, Tam reduced offense. Defense also changed in those pairings, but that activity seemed related to the amount of attack received. Tamoxifen had little influence on the weights of accessory sex glands. The data confirm that Tam is a potent suppressor of "androgen-dependent" aggression in male laboratory mice and provide further support for the aromatization hypothesis.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Hasan SA,Brain PF,Castano D

doi

10.1016/0018-506x(88)90064-5

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

178-85

issue

2

eissn

0018-506X

issn

1095-6867

pii

0018-506X(88)90064-5

journal_volume

22

pub_type

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