Abstract:
:There is growing evidence from preclinical studies for an involvement of orexins (ORX) in the regulation of stress, affectivity and addictive behavior. The aim of our study was to gather corresponding clinical data and to elucidate the relationships between alcohol withdrawal stress, ORX plasma concentration and psychopathology. A consecutive sample of thirty-four alcohol-dependent inpatients was included in the study. Blood was drawn at onset of withdrawal and following 2 weeks of controlled abstinence in order to assess ORX, ACTH and cortisol plasma concentrations. In parallel, we assessed clinically relevant psychological distress symptoms applying the Brief Symptom Inventory (BSI). We found a significant positive correlation between ORX and global distress indices of the BSI (p ≤ 0.05). In a regression model, ORX concentration during acute withdrawal explained 24% of the variance of symptom severity (p<0.01). No association with craving, ACTH or cortisol plasma concentration was detected. Our results suggest an involvement of ORX in the affective dysregulation seen commonly in alcohol dependent patients during alcohol withdrawal. Moreover, the effects on global distress indices as well as the earlier studied effects on reinstatement of drug seeking behaviors may point on an involvement of ORX in impaired brain stress systems.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
von der Goltz C,Koopmann A,Dinter C,Richter A,Grosshans M,Fink T,Wiedemann K,Kiefer Fdoi
10.1016/j.yhbeh.2011.08.017subject
Has Abstractpub_date
2011-11-01 00:00:00pages
644-50issue
5eissn
0018-506Xissn
1095-6867pii
S0018-506X(11)00209-1journal_volume
60pub_type
杂志文章abstract::This article is part of a Special Issue "Energy Balance". Obesity and its associated comorbidities remain at epidemic levels globally and show no signs of abatement in either adult or child populations. White adipose tissue has long been established as an endocrine signalling organ possessing both metabolic and immune...
journal_title:Hormones and behavior
pub_type: 杂志文章,评审
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abstract::Oxytocin is important for postnatal developmental experiences for mothers, infants, and transactions between them. Oxytocin is also implicated in adult affiliative behaviors, including social buffering of stress. There is evidence for connections between early life experience and adult oxytocin system functioning, but...
journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2011.09.001
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abstract::Selective breeding of rats exhibiting differences in novelty-induced locomotion revealed that this trait predicts several differences in emotional behavior. Bred High Responders (bHRs) show exaggerated novelty-induced locomotion, aggression, and psychostimulant self-administration, compared to bred Low Responders (bLR...
journal_title:Hormones and behavior
pub_type: 杂志文章
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2017.11.007
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2006.06.006
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abstract::Female assessment of male attractiveness and how preferred qualities impact reproductive success is central to the study of mate choice. Male attractiveness may depend on traits beneficial to the reproductive success (RS) of any female, termed 'universal quality', and/or on behavioral and biological interactions betwe...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2011.10.009
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abstract::Experimental findings suggest that the melatonin system has a beneficial role in models of Alzheimer's disease (ADs). The aim of the present study was to explore whether the atypical antidepressant agomelatine (Ago), which is a melatonin MT1 and MT2 agonist and 5-HT2C antagonist, is effective against behavioral, bioch...
journal_title:Hormones and behavior
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doi:10.1016/j.yhbeh.2018.11.007
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journal_title:Hormones and behavior
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doi:10.1016/j.yhbeh.2012.05.009
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journal_title:Hormones and behavior
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journal_title:Hormones and behavior
pub_type: 杂志文章
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2011.04.003
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journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2014.06.017
更新日期:2014-07-01 00:00:00
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journal_title:Hormones and behavior
pub_type: 杂志文章
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journal_title:Hormones and behavior
pub_type: 杂志文章,评审
doi:10.1016/j.yhbeh.2014.04.005
更新日期:2014-06-01 00:00:00
abstract::Detrimental consequences of prenatal stress include increased hypothalamic-pituitary-adrenal (HPA) function, anxiety and depression-like behavior in adult offspring. To identify the role of maternal corticosterone milieu in the fetal programming of adult function, we measured these same behavioral and hormonal endpoin...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2006.11.006
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abstract::In the field as well as in the laboratory, human-generated stress responses are reduced in adult animals previously habituated to humans in comparison to non-habituated individuals. In birds, yolk steroid levels vary with maternal environment and condition. We tested the hypothesis that the experience of female birds ...
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2008.04.012
更新日期:2008-08-01 00:00:00
abstract::Short-term fluctuations in steroid hormones such as estradiol (E2) and progesterone (P) can affect the concentration of hippocampal dendritic spines in adult, cycling nulliparous female rats. Pregnancy is characterized by a significantly longer duration of substantially elevated E2 and P compared to the estrous cycle....
journal_title:Hormones and behavior
pub_type: 杂志文章
doi:10.1016/j.yhbeh.2005.05.017
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