Abstract：
:Oxytocin is important for postnatal developmental experiences for mothers, infants, and transactions between them. Oxytocin is also implicated in adult affiliative behaviors, including social buffering of stress. There is evidence for connections between early life experience and adult oxytocin system functioning, but effects of early experience on behavioral, endocrine, and neurophysiological outcomes related to adult social buffering are not well explored. We use a limited bedding and nesting (LBN) material paradigm as an environmental disruption of early experiences and assessed central oxytocin systems in brain regions related to hypothalamic-pituitary-adrenal (HPA) axis regulation (paraventricular nucleus of the hypothalamus, amygdala, hippocampus). We also assessed developmentally-appropriate social behaviors and HPA reactivity during social buffering testing in adulthood. LBN litters had larger huddles and more pups visible compared to control litters during the first two weeks of life. LBN also altered the developmental trajectory of oxytocin-expressing cells and oxytocin receptor cells, with increases in oxytocin receptor cells at P15 in LBN pups. By adulthood, LBN females had more and LBN males had fewer oxytocin and oxytocin receptor cells in these areas compared to sex-matched controls. Adult LBN females, but not LBN males, had behavioral changes during social interaction and social buffering testing. The sex-specific effects of early experience on central oxytocin systems and social behavior may contribute to female resilience to early life adversity.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Lapp HE,Bartlett AA,Zup SL,Hunter RG,Moore CLdoi
10.1016/j.yhbeh.2020.104822subject
Has Abstractpub_date
2020-11-01 00:00:00pages
104822eissn
0018-506Xissn
1095-6867pii
S0018-506X(20)30148-3journal_volume
126pub_type
杂志文章abstract：:Stress has been associated with negative changes observed during the aging process. However, very little research has been carried out on the role of age in acute stress effects on memory. We aimed to explore the role of age and sex in the relationship between hypothalamus-pituitary-adrenal axis (HPA-axis) and sympath...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2013.12.017
更新日期：2014-03-01 00:00:00
abstract：:Early life experiences are important for the development of neurobiobehavioral mechanisms and subsequent establishment of mental functions. In experimental animals, early life experiences can be studied using the maternal separation model. Maternal separation has been described to induce neurobiological changes and th...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2006.06.016
更新日期：2006-12-01 00:00:00
abstract：:Food restricting lactating rat dams over the first 2 weeks of lactation results in a prolongation of the period of lactational diestrus. Such food restriction has not only a direct effect on the dam but also the pups are undernourished, and the pattern of dam-litter contact is also changed. In a series of studies, we ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1995.1012
更新日期：1995-06-01 00:00:00
abstract：:It has been hypothesized that in avian social groups subordinate individuals should maintain more energy reserves than dominants, as an insurance against increased perceived risk of starvation. Subordinates might also have elevated baseline corticosterone levels because corticosterone is known to facilitate fattening ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/s0018-506x(03)00119-3
更新日期：2003-08-01 00:00:00
abstract：:To determine across-year patterns in plasma testosterone (T) and corticosterone (B) levels in free-living birds, we took blood samples in the same 2-week breeding period during 4 consecutive years from territorial male red-winged blackbirds. We used our data to test predictions of the "challenge hypothesis" of T secre...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(92)90011-j
更新日期：1992-09-01 00:00:00
abstract：:The brain of the adult teleost fish exhibits intense neurogenic activity and an outstanding capability for brain repair. Remarkably, the brain estrogen-synthesizing enzyme, aromatase B, is strongly expressed, particularly in adult fishes, in radial glial cells, which act as progenitors. Using zebrafish, we tested the ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2012.04.003
更新日期：2013-02-01 00:00:00
abstract：:Ghrelin is an orexigenic hormone that regulates homeostatic and reward-related feeding behavior. Recent evidence indicates that acylation of ghrelin by the gut enzyme ghrelin O-acyl transferase (GOAT) is necessary to render ghrelin maximally active within its target tissues. Here we tested the hypothesis that GOAT act...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2012.08.009
更新日期：2012-11-01 00:00:00
abstract：:Progesterone receptor (PR) is expressed in Cajal-Retzius (CR) cells of the dentate gyrus (DG) molecular layer during the postnatal period (P1-28), a critical stage of development for the dentate gyrus and its circuitry. CR cells secrete the glycoprotein, reelin, which is required for typical development of the DG and ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2020.104887
更新日期：2021-01-01 00:00:00
abstract：:The first issue of Hormones and Behavior was published 50 years ago in 1969, a time when most of the techniques we currently use in Behavioral Endocrinology were not available. Researchers have during the last 5 decades developed techniques that allow measuring hormones in small volumes of biological samples, identify...
journal_title：Hormones and behavior
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.yhbeh.2020.104682
更新日期：2020-02-01 00:00:00
abstract：:Environmental perturbations increase adrenal activity in several vertebrates. Increases in corticosterone may serve as a proximate trigger whereby organisms can rapidly adapt their behavior to survive environmental fluctuations. In food-caching songbirds, inclement weather may present the need to alter caching and/or ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.2000.1571
更新日期：2000-03-01 00:00:00
abstract：:Fighting behavior between male copperheads (Agkistrodon contortrix) occurs during the two mating periods (late summer/fall and spring) to gain priority of access to females. Fights are characterized by prominent vertical challenge displays, swaying, and a high degree of physical contact that does not involve biting. A...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1996.0009
更新日期：1996-03-01 00:00:00
abstract：:Previous studies have documented the ability of neural grafts to stimulate the recovery of lordosis from neurochemical deficits. However, it was unclear if grafts also could reverse deficits in lordosis caused by lesions at critical points in the neural circuit controlling this response. To address this question, fema...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1997.1421
更新日期：1997-12-01 00:00:00
abstract：:The hormonal control of territorial aggression in male and female vertebrates outside the breeding season is still unresolved. Most vertebrates have regressed gonads when not breeding and do not secrete high levels of sex steroids. However, recent studies implicate estrogens in the regulation of non-breeding territori...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2003.08.002
更新日期：2004-01-01 00:00:00
abstract：:Two experiments assessed the effects of neonatal testosterone treatment on paced mating behavior and conditioned place preference in female rats. In both experiments, females received s.c. injections of 5.0 microg testosterone propionate or oil vehicle at three days postpartum. As adults, females were ovariectomized a...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/s0018-506x(03)00157-0
更新日期：2003-11-01 00:00:00
abstract：:The neuropeptide Oxytocin (OT) has been implicated in many aspects of mammalian social behavior. This study investigates how OT interacts with two well-studied determinants of cooperative behavior: incentives and social information. Participants received OT or a placebo and played two economic games: a Coordination Ga...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2010.01.006
更新日期：2010-03-01 00:00:00
abstract：:Primates maintain a variety of social relationships and these can have fitness consequences. Research has established that different types of social relationships are unpinned by different or interacting hormonal systems, for example, the neuropeptide oxytocin influences social bonding, the steroid hormone testosteron...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2017.03.004
更新日期：2017-05-01 00:00:00
abstract：:Intact male rats were tested on two successive weekly tests with females to determine their level of sexual activity. Nuclear estrogen receptor content was measured in specific brain regions of individual sexually responsive and sexually nonresponsive males. Sexually nonresponsive male rats had significantly reduced n...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(85)90022-4
更新日期：1985-06-01 00:00:00
abstract：:After proposing the organizational hypothesis from research in prenatally androgenized guinea pigs (Phoenix, C.H., Goy, R.W., Gerall, A.A., Young, W.C., 1959. Organizational action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 65, 36...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2009.03.015
更新日期：2009-05-01 00:00:00
abstract：:Behavioral studies of an XY gonadal dysgenetic chacma baboon under estradiol benzoate treatment were carried out. The dysgenetic individual and two ovariectomized conspecific control females were given a total of three testing series. The dysgenetic individual showed progressive success in her sexual interactions with...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(84)90042-4
更新日期：1984-06-01 00:00:00
abstract：:Urine deposited by a rat on a conspecific was quantified with injections of sodium fluorescein, a substance that changes the color of urine. The hypothesis examined in experiment 1 was that marking the environment and a conspecific would be similarly androgen-sensitive behaviors during each of three stages--before cas...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/0018-506x(87)90048-1
更新日期：1987-06-01 00:00:00
abstract：:In previous studies, we showed for the first time that prenatal stress in rats produces long-term alterations of formalin-induced pain behavior that are dependent on age and sex, and we demonstrated an important role of the serotonergic system in mechanisms of prenatal stress (Butkevich, I.P. and Vershinina, E.A., 200...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2008.09.008
更新日期：2009-01-01 00:00:00
abstract：:Tonic immobility (TI) is also known as "immobility response", "immobility reflex", "animal hypnosis", etc. It is an innate antipredatory behavior characterized by an absence of movement, varying degrees of muscular activity, and a relative unresponsiveness to external stimuli. Experimentally, TI is commonly produced b...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.07.013
更新日期：2011-09-01 00:00:00
abstract：:Glucocorticoids are thought to mediate the disruption of parental behavior in response to acute and chronic stress. Previous research supports their role in chronic stress; however, no study has experimentally tested the effects of acute glucocorticoid elevation on paternal behavior. We tested the prediction that acut...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2011.09.001
更新日期：2011-11-01 00:00:00
abstract：:It is well established that in many avian species, prenatal maternal resource allocation varies both between and within clutches and may affect offspring fitness. Differential allocation of maternal resources, in terms of egg weight and yolk composition, may therefore allow the female to adjust brood reduction and to ...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2015.03.009
更新日期：2015-05-01 00:00:00
abstract：:The present study examined whether the following variables putatively associated with prenatal androgens are inter-related in women: spatial abilities, sexual orientation, and 2nd to 4th finger (digit) length ratio (2D:4D). Participants were 99 healthy premenopausal women tested in the menstrual phase of the ovarian c...
journal_title：Hormones and behavior
pub_type： 临床试验,杂志文章
doi：10.1016/j.yhbeh.2004.09.003
更新日期：2005-01-01 00:00:00
abstract：:Conspicuous swellings of the perineal skin can be observed in females of many catharrine primate species particularly during the middle stages of the ovarian cycle. The functional significance of this trait remains poorly understood. Recently, two hypotheses, the "reliable indicator" hypothesis and the "graded signal"...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2004.03.013
更新日期：2004-08-01 00:00:00
abstract：:Nazca boobies (Sula granti) show unconditional obligate siblicide immediately after hatching, reducing the typical two-egg clutch size to one. We studied body mass changes and levels of testosterone (T), corticosterone (CORT), and progesterone (P) for A-chicks (dominant, first hatched), B-chicks (subordinate, second h...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.2001.1661
更新日期：2001-08-01 00:00:00
abstract：:Mating, marking and the sexually dimorphic area (SDA) were studied in male gerbils that were castrated or sham-operated on the day of birth and in females given testosterone (T) propionate or oil 1 day later. Other females received dihydrotestosterone (DHT), R1881, estradiol benzoate (EB), R2858, DHT and EB, or DHT an...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1006/hbeh.1996.0015
更新日期：1996-06-01 00:00:00
abstract：:This article is part of a Special Issue "Puberty and Adolescence". This paper examines consistency of effects of pubertal timing (going through puberty earlier, later or at the same time one's cohort of peers) on the development of psychopathology during adolescence as well as the persistence of effects into adulthood...
journal_title：Hormones and behavior
pub_type： 杂志文章,评审
doi：10.1016/j.yhbeh.2013.04.003
更新日期：2013-07-01 00:00:00
abstract：:Humans and wildlife are exposed to numerous anthropogenic drugs and pollutants. Many of these compounds are hormonally active, and recent evidence suggests that the presence of these endocrine disruptors permanently alters normal development and physiology in a variety of vertebrate species. Here, we report on the eff...
journal_title：Hormones and behavior
pub_type： 杂志文章
doi：10.1016/j.yhbeh.2006.01.007
更新日期：2006-06-01 00:00:00
