Testosterone and estradiol produce different effects on cognitive performance in male rats.

Abstract:

:The effects of castration and hormone treatment on cognitive performance were evaluated in male rats. Castrated animals received either testosterone or estradiol and were compared with gonadally intact animals and with castrated controls. Results revealed a dissociation between the effects of testosterone and estradiol on cognitive performance in male rats. Specifically, estradiol enhanced acquisition of a delayed matching-to-position spatial task, similar to previously published observations in females. In contrast, neither castration nor testosterone treatment had any significant effect on acquisition of the delayed matching-to-position task, but did appear to affect delay-dependent working memory. None of the treatments had any significant effect on acquisition of a configural association negative patterning task, suggesting that effects on the delayed matching-to-position task were not due to effects on motivational factors. These data demonstrate that, as in females, gonadal hormones influence cognitive performance in males and suggest that estradiol and testosterone affect distinct cognitive domains.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Gibbs RB

doi

10.1016/j.yhbeh.2005.03.005

keywords:

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

268-77

issue

3

eissn

0018-506X

issn

1095-6867

pii

S0018-506X(05)00084-X

journal_volume

48

pub_type

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