Estrogen increases the sensitivity of ovariectomized rats to the disruptive effects produced by antagonism of D2 but not D1 dopamine receptors during performance of a response learning task.

Abstract:

:Estrogen impairs performance on some striatum-sensitive tasks of learning and memory. Evidence indicates that it may have these impairing effects by creating a bias to use hippocampally based strategies to solve tasks whether or not it is advantageous to do so. Estrogen may also exert direct effects in the striatum to affect performance on striatum-mediated procedural memory tasks. In spite of the robust effects that estrogen exerts on nigrostriatal dopaminergic neurons, the role of dopamine in the estrogen-induced effects on procedural memory tasks remains unexplored. The goal of the present study was to assess the independent and interactive effects of estrogen and dopamine antagonists on a striatum-mediated response learning task. Adult rats were ovariectomized and implanted with Silastic capsules containing 25% estradiol diluted in cholesterol or 100% cholesterol. Rats were trained to receive food rewards in an elevated plus maze by making a specified response (right or left turn). Following acquisition, dose-effect curves were determined for the D(1) dopamine receptor antagonist, SCH 23390, and the D(2) dopamine receptor antagonist, eticlopride. Estrogen did not significantly affect acquisition of the task and had no significant effect on the ability of SCH 23390 to disrupt performance on the task. However, estrogen significantly increased the sensitivity of the rats to the error-increasing effects of eticlopride. These results indicate that estrogen may differentially interact with D(1) and D(2) dopamine receptors to affect response learning. They also suggest that in addition to creating a bias to use hippocampally based strategies to solve tasks, estrogen may affect performance on procedural memory tasks through direct action on dopaminergic functioning.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Daniel JM,Sulzer JK,Hulst JL

doi

10.1016/j.yhbeh.2005.05.001

keywords:

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

38-44

issue

1

eissn

0018-506X

issn

1095-6867

pii

S0018-506X(05)00120-0

journal_volume

49

pub_type

杂志文章
  • Sex-dependent effects of social status on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT), and serotonin (5-HT) 1A receptor binding and aggression in Syrian hamsters (Mesocricetus auratus).

    abstract::Dominance status in hamsters is driven by interactions between arginine-vasopressin V1a, oxytocin (OT), and serotonin 1A (5-HT1A) receptors. Activation of V1a and OT receptors in the anterior hypothalamus (AH) increases aggression in males, while decreasing aggression in females. In contrast, activation of 5-HT1A rece...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2020.104878

    authors: Grieb ZA,Ross AP,McCann KE,Lee S,Welch M,Gomez MG,Norvelle A,Michopoulos V,Huhman KL,Albers HE

    更新日期:2021-01-01 00:00:00

  • Galanthamine plus estradiol treatment enhances cognitive performance in aged ovariectomized rats.

    abstract::We hypothesize that beneficial effects of estradiol on cognitive performance diminish with age and time following menopause due to a progressive decline in basal forebrain cholinergic function. This study tested whether galanthamine, a cholinesterase inhibitor used to treat memory impairment associated with Alzheimer'...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2011.08.010

    authors: Gibbs RB,Chipman AM,Hammond R,Nelson D

    更新日期:2011-11-01 00:00:00

  • Effects of estradiol in adult neurogenesis and brain repair in zebrafish.

    abstract::The brain of the adult teleost fish exhibits intense neurogenic activity and an outstanding capability for brain repair. Remarkably, the brain estrogen-synthesizing enzyme, aromatase B, is strongly expressed, particularly in adult fishes, in radial glial cells, which act as progenitors. Using zebrafish, we tested the ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2012.04.003

    authors: Diotel N,Vaillant C,Gabbero C,Mironov S,Fostier A,Gueguen MM,Anglade I,Kah O,Pellegrini E

    更新日期:2013-02-01 00:00:00

  • Female sexual swelling size, timing of ovulation, and male behavior in wild West African chimpanzees.

    abstract::Conspicuous swellings of the perineal skin can be observed in females of many catharrine primate species particularly during the middle stages of the ovarian cycle. The functional significance of this trait remains poorly understood. Recently, two hypotheses, the "reliable indicator" hypothesis and the "graded signal"...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2004.03.013

    authors: Deschner T,Heistermann M,Hodges K,Boesch C

    更新日期:2004-08-01 00:00:00

  • Epigenetics and the origins of paternal effects.

    abstract::Though there are multiple routes through which parents can influence their offspring, recent studies of environmentally induced epigenetic variation have highlighted the role of non-genomic pathways. In addition to the experience-dependent modification of DNA methylation that can be achieved via mother-infant interact...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.yhbeh.2010.06.018

    authors: Curley JP,Mashoodh R,Champagne FA

    更新日期:2011-03-01 00:00:00

  • How prior pair-bonding experience affects future bonding behavior in monogamous prairie voles.

    abstract::Monogamous prairie voles (Microtus ochrogaster) form mating-based pair bonds. Although wild prairie voles rarely re-pair following loss of a partner, laboratory studies have shown that previous pairing and mating does not negate the ability to form a new partner preference. However, little is known about how prior bon...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2020.104847

    authors: Harbert KJ,Pellegrini M,Gordon KM,Donaldson ZR

    更新日期:2020-11-01 00:00:00

  • Oxytocin antagonist treatments alter the formation of pair relationships in zebra finches of both sexes.

    abstract::Oxytocin and vasopressin are known to be important in affiliative behaviors. Although these peptides have been shown to be involved in monogamous pairing behavior in a few mammalian species, their role across monogamous species is not well understood. In particular, monogamy is most common in birds, yet the role of me...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2012.05.009

    authors: Pedersen A,Tomaszycki ML

    更新日期:2012-07-01 00:00:00

  • Sex or candy? Neuroendocrine regulation of the seasonal transition from courtship to feeding behavior in male red-sided garter snakes (Thamnophis sirtalis parietalis).

    abstract::This article is part of a Special Issue "Energy Balance". Seasonal modulation of glucocorticoids plays an important role in supporting critical life-history events, and probably facilitates transitions between different life-history stages. In a well-studied population of red-sided garter snakes (Thamnophis sirtalis p...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2014.01.011

    authors: Lutterschmidt DI,Maine AR

    更新日期:2014-06-01 00:00:00

  • High self-perceived stress and many stressors, but normal diurnal cortisol rhythm, in adults with ADHD (attention-deficit/hyperactivity disorder).

    abstract::Attention-deficit/hyperactivity disorder (ADHD) in adults is associated with significant impairment in many life activities and may thus increase the risk of chronic stress in everyday life. We compared adults with a DSM-IV ADHD diagnosis (n=28) with healthy controls (n=28) regarding subjective stress and amounts of s...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2008.12.004

    authors: Hirvikoski T,Lindholm T,Nordenström A,Nordström AL,Lajic S

    更新日期:2009-03-01 00:00:00

  • Androgens modulate song effort and aggression in Neotropical singing mice.

    abstract::Androgens are an important class of steroid hormones involved in modulating the expression and evolution of male secondary sex characters. Vocalizations used in the context of aggression and mate attraction are among the most elaborate and diverse androgen-dependent animal displays as reflected in a rich tradition of ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2010.10.011

    authors: Pasch B,George AS,Hamlin HJ,Guillette LJ Jr,Phelps SM

    更新日期:2011-01-01 00:00:00

  • Neuropeptidergic regulation of affiliative behavior and social bonding in animals.

    abstract::Social relationships are essential for maintaining human mental health, yet little is known about the brain mechanisms involved in the development and maintenance of social bonds. Animal models are powerful tools for investigating the neurobiological mechanisms regulating the cognitive processes leading to the develop...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.yhbeh.2006.06.028

    authors: Lim MM,Young LJ

    更新日期:2006-11-01 00:00:00

  • Rapid effects of estradiol on aggression depend on genotype in a species with an estrogen receptor polymorphism.

    abstract::The white-throated sparrow (Zonotrichia albicollis) represents a powerful model in behavioral neuroendocrinology because it occurs in two plumage morphs that differ with respect to steroid-dependent social behaviors. Birds of the white-striped (WS) morph engage in more territorial aggression than do birds of the tan-s...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2017.11.014

    authors: Merritt JR,Davis MT,Jalabert C,Libecap TJ,Williams DR,Soma KK,Maney DL

    更新日期:2018-02-01 00:00:00

  • The passerine hippocampus is a site of high aromatase: inter- and intraspecies comparisons.

    abstract::The vertebrate hippocampus (HP) plays a critical role in the organization of memory. Estrogens alter synaptic morphology and function in the mammalian HP and may potentiate memory performance. Previous studies suggest that the songbird HP itself is a site of significant aromatase expression, intimating that local estr...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.1998.1447

    authors: Saldanha CJ,Popper P,Micevych PE,Schlinger BA

    更新日期:1998-10-01 00:00:00

  • Plasma levels of androgens and cortisol in relation to breeding behavior in parental male bluegill sunfish, Lepomis macrochirus.

    abstract::Like many teleosts, male bluegill sunfish (Lepomis macrochirus) provide sole parental care. To understand some of the proximate costs of parental care, we measured body condition and plasma levels of testosterone (T), 11-ketotestosterone (11KT) and cortisol in nesting bluegill males during pre-spawning, spawning and p...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2005.12.003

    authors: Magee SE,Neff BD,Knapp R

    更新日期:2006-05-01 00:00:00

  • Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence.

    abstract::There is growing evidence from preclinical studies for an involvement of orexins (ORX) in the regulation of stress, affectivity and addictive behavior. The aim of our study was to gather corresponding clinical data and to elucidate the relationships between alcohol withdrawal stress, ORX plasma concentration and psych...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2011.08.017

    authors: von der Goltz C,Koopmann A,Dinter C,Richter A,Grosshans M,Fink T,Wiedemann K,Kiefer F

    更新日期:2011-11-01 00:00:00

  • Activation of androgen receptors protects intact male mice from memory impairments caused by aromatase inhibition.

    abstract::Although 17β-estradiol (E2) is known to regulate hippocampal function, the specific contributions of hippocampally-synthesized E2 remain unclear. Infusion of the aromatase inhibitor letrozole into the dorsal hippocampus (DH) of ovariectomized mice disrupts object recognition and object placement memory consolidation, ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2019.01.002

    authors: Koss WA,Frick KM

    更新日期:2019-05-01 00:00:00

  • Pre-pubertal gonadectomy and the social consequences of acute ethanol in adolescent male and female rats.

    abstract::It has previously been shown that pre-pubertal or adult gonadectomy (GX) increases ethanol intake in male rats. This study examined whether this sex-selective increase reflects a GX-induced maintenance in males of more adolescent-typical responsiveness to ethanol characterized by enhanced sensitivity to positive (e.g....

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2014.04.015

    authors: Morales M,Varlinskaya EI,Spear LP

    更新日期:2014-07-01 00:00:00

  • Sex differences in cortisol's regulation of affiliative behavior.

    abstract::A contribution to a special issue on Hormones and Human Competition. A stress perspective is used to illuminate how competitive defeat and victory shape biology and behavior. We report a field study examining how change in cortisol following perceived defeat (vs. victory) in a competition-in this case, a dog agility c...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2016.12.005

    authors: Sherman GD,Rice LK,Jin ES,Jones AC,Josephs RA

    更新日期:2017-06-01 00:00:00

  • Territorial aggression and hormones during the non-breeding season in a tropical bird.

    abstract::The hormonal control of territorial aggression in male and female vertebrates outside the breeding season is still unresolved. Most vertebrates have regressed gonads when not breeding and do not secrete high levels of sex steroids. However, recent studies implicate estrogens in the regulation of non-breeding territori...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2003.08.002

    authors: Hau M,Stoddard ST,Soma KK

    更新日期:2004-01-01 00:00:00

  • Year-to-year patterns of circulating levels of testosterone and corticosterone in relation to breeding density, experience, and reproductive success of the polygynous red-winged blackbird.

    abstract::To determine across-year patterns in plasma testosterone (T) and corticosterone (B) levels in free-living birds, we took blood samples in the same 2-week breeding period during 4 consecutive years from territorial male red-winged blackbirds. We used our data to test predictions of the "challenge hypothesis" of T secre...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/0018-506x(92)90011-j

    authors: Beletsky LD,Orians GH,Wingfield JC

    更新日期:1992-09-01 00:00:00

  • A daily rhythm in mating behavior in a diurnal murid rodent Arvicanthis niloticus.

    abstract::The time of day at which mating occurs is dramatically different in diurnal compared to nocturnal rodents. We used a diurnal murid rodent, Arvicanthis niloticus, to determine if inverted rhythms in responsiveness to hormones contribute to this difference. Male and hormone-primed female grass rats were tested for matin...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2004.07.006

    authors: Mahoney MM,Smale L

    更新日期:2005-01-01 00:00:00

  • Altered attention networks in patients with thyroid dysfunction: A neuropsychological study.

    abstract::Patients with thyroid dysfunction (31 hypothyroid, 32 subclinical hypothyroidism, 34 hyperthyroid, and 30 subclinical hyperthyroidism) and 37 euthyroid control subjects were recruited and performed the attention network test (ANT), which can simultaneously examine the alertness, orientation and execution control of th...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2020.104714

    authors: Yuan L,Luan D,Xu X,Yang Q,Huang X,Zhao S,Zhang Y,Zhou Z

    更新日期:2020-05-01 00:00:00

  • Correlates of maternal glucocorticoid levels in a socially flexible rodent.

    abstract::While it is generally accepted that social isolation has detrimental effects on social species, little is known about the importance of social interactions in less social species-particularly for wild reproductive females. We studied socially-flexible yellow-bellied marmots (Marmota flaviventer) and asked whether feat...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2019.104577

    authors: Pinho GM,Ortiz-Ross X,Reese AN,Blumstein DT

    更新日期:2019-11-01 00:00:00

  • Estrogen implants in the medial preoptic area stimulate maternal behavior in male rats.

    abstract::The present study investigated whether the medial preoptic area (MPOA) mediates estrogen stimulation of maternal behavior in the male as it does in the female. Previous studies have shown that lesions of the medial preoptic area prevent sensitization of maternal behavior in male rats and that in gonadectomized, hormon...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.1997.1430

    authors: Rosenblatt JS,Ceus K

    更新日期:1998-02-01 00:00:00

  • Interaction effects of corticosterone and experience on aggressive behavior in the green anole lizard.

    abstract::Aggressive encounters are accompanied by a release of stress hormone, and this corticosterone (CORT) secretion could influence aggressive behavior in subsequent encounters. We investigated the modulating effects of CORT on aggressive behavior in the context of a 5-day social experience in male green anole lizards. In ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/s0018-506x(03)00139-9

    authors: Yang EJ,Wilczynski W

    更新日期:2003-09-01 00:00:00

  • Subchronic 17alpha-ethinyl estradiol differentially affects subtypes of sleep and wakefulness in ovariectomized rats.

    abstract::In ovariectomized (OVX) Sprague-Dawley rats, estradiol benzoate (EB) has been reported to decrease rapid eye movement (REM) and non-REM (NREM) sleep during the dark phase for up to 3 days. It is unknown, however, if estrogenic effects on sleep extend beyond 3 days or if other estrogens could induce the same changes. F...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2007.09.018

    authors: Pawlyk AC,Alfinito PD,Johnston GH,Deecher DC

    更新日期:2008-01-01 00:00:00

  • Estrogen therapy and brain muscarinic receptor density in healthy females: a SPET study.

    abstract::Estrogen Therapy (ET) may protect against age-related cognitive decline and neuropsychiatric disorders (e.g. Alzheimer's disease). The biological basis for this putative neuroprotective effect is not fully understood, but may include modulation of cholinergic systems. Cholinergic dysfunction has been implicated in age...

    journal_title:Hormones and behavior

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.yhbeh.2006.10.007

    authors: Norbury R,Travis MJ,Erlandsson K,Waddington W,Ell PJ,Murphy DG

    更新日期:2007-02-01 00:00:00

  • Effects of testosterone propionate upon the sexual and aggressive behavior of adult male marmosets (Callithrix jacchus) castrated as neonates.

    abstract::In New World monkeys of the family Callitrichidae (marmosets and tamarins), females frequently give birth to dizygotic twins. Twins share a placental circulation throughout fetal development and are hemopoietic chimeras. Despite this, there is no masculinization (freemartinism) in females which develop next to a male ...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1006/hbeh.1993.1016

    authors: Dixson AF

    更新日期:1993-06-01 00:00:00

  • Regulation of vernal migration in Gambel's white-crowned sparrows: Role of thyroxine and triiodothyronine.

    abstract::Appropriate timing of migratory behavior is critical for migrant species. For many temperate zone birds in the spring, lengthening photoperiod is the initial cue leading to morphological, physiological and behavior changes that are necessary for vernal migration and breeding. Strong evidence has emerged in recent year...

    journal_title:Hormones and behavior

    pub_type: 杂志文章

    doi:10.1016/j.yhbeh.2016.05.021

    authors: Pérez JH,Furlow JD,Wingfield JC,Ramenofsky M

    更新日期:2016-08-01 00:00:00

  • Effects of opioid- and non-opioid analgesics on responses to psychosocial stress in humans.

    abstract::Both preclinical and clinical evidence suggests that the endogenous opioid system is involved in responses to stress. For example, in animal models opioid agonists reduce isolation distress whereas opioid antagonists increase isolation distress. We recently reported that the mixed mu agonist and kappa antagonist bupre...

    journal_title:Hormones and behavior

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.yhbeh.2018.04.009

    authors: Bershad AK,Miller MA,Norman GJ,de Wit H

    更新日期:2018-06-01 00:00:00