Abstract：
:Hepatitis C virus (HCV) infection induces steatosis and is accompanied by multiple metabolic alterations including hyperuricemia, reversible hypocholesterolemia and insulin resistance. Total cholesterol, low-density lipoprotein-cholesterol and triglyceride levels are increased by peginterferon and ribavirin combination therapy when a sustained virologic response (SVR) is achieved in patients with HCV. Steatosis is significantly more common in patients with HCV genotype 3 but interferon-free regimens are not always effective for treating HCV genotype 3 infections. HCV infection increases fatty acid synthase levels, resulting in the accumulation of fatty acids in hepatocytes. Of note, low-density lipoprotein receptor, scavenger receptor class B type I and Niemann-Pick C1-like 1 proteins are candidate receptors that may be involved in HCV. They are also required for the uptake of cholesterol from the external environment of hepatocytes. Among HCV-infected patients with or without human immunodeficiency virus infection, changes in serum lipid profiles are observed during interferon-free treatment and after the achievement of an SVR. It is evident that HCV affects cholesterol metabolism during interferon-free regimens. Although higher SVR rates were achieved with interferon-free treatment of HCV, special attention must also be paid to unexpected adverse events based on host metabolic changes including hyperlipidemia.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Kanda T,Moriyama Mdoi
10.3748/wjg.v23.i31.5645subject
Has Abstractpub_date
2017-08-21 00:00:00pages
5645-5649issue
31eissn
1007-9327issn
2219-2840journal_volume
23pub_type
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journal_title：World journal of gastroenterology
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pub_type： 杂志文章
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pub_type： 社论,评审
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journal_title：World journal of gastroenterology
pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,meta分析
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pub_type： 杂志文章
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v16.i13.1622
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pub_type： 杂志文章
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