Abstract：
:The hypothalamus consists of numerous nuclei, and is regarded as the highest center for various autonomic functions. Although each hypothalamic nucleus implements a distinct function, it remains difficult to investigate the human hypothalamus at the nucleus level. In the present high-resolution functional MRI study, we utilized areal parcellation to discriminate individual nuclei in the human hypothalamus based on areal profiles of resting-state functional connectivity. The areal parcellation detected ten foci that were expected to represent hypothalamic nuclei, and the locations of the foci were consistent with those of the hypothalamic nuclei identified in previous histological studies. Regions of interest (ROI) analyses revealed contrasting brain activity changes following glucose ingestion: decrease in the ventromedial hypothalamic nucleus and increase in the lateral hypothalamic area in parallel with blood glucose increase. Moreover, decreased brain activity in the arcuate nucleus predicted future elevation of blood insulin during the first 10 min after glucose ingestion. These results suggest that the hypothalamic nuclei can putatively be determined using areal parcellation, and that the ROI analysis of the human hypothalamic nuclei is useful for future scientific and clinical investigations into the autonomic functions.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Osada T,Suzuki R,Ogawa A,Tanaka M,Hori M,Aoki S,Tamura Y,Watada H,Kawamori R,Konishi Sdoi
10.1016/j.neuroimage.2017.08.056subject
Has Abstractpub_date
2017-11-15 00:00:00pages
1-12eissn
1053-8119issn
1095-9572pii
S1053-8119(17)30703-6journal_volume
162pub_type
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