Abstract:
:Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by progressive behavioural abnormalities and frontotemporal atrophy. Here we used tensor based morphometry (TBM) to identify regions of longitudinal progression of gray matter atrophy in FTD compared to controls. T1-weighted MRI images were acquired at presentation and 1-year follow-up from 12 patients with mild to moderate FTD and 12 healthy controls. Using TBM as implemented in SPM2, a voxel-wise estimation of regional tissue volume change was derived from the deformation field required to warp a subject's late to early anatomical images. A whole brain analysis was performed, in which a level of significance of p<0.05 corrected for multiple comparisons (family wise error-FWE) was accepted. Based on prior studies, a region of interest (ROI) analysis was also performed, including in the search area bilateral medial and orbital frontal regions, anterior cingulate gyrus, insula, amygdala and hippocampus. Within this ROI a level of significance of p<0.001 uncorrected was accepted. In the whole brain analysis, the anterior cingulate/paracingulate gyri were the only regions that showed significant atrophy change over 1 year. In the ROI analysis, the left ventro-medial frontal cortex, right medial superior frontal gyrus, anterior insulae and left amygdala/hippocampus showed significant longitudinal changes. In conclusion, limbic and paralimbic regions showed detectable gray matter contraction over 1 year in FTD, confirming the susceptibility of these regions to the disease and the consistency with their putative role in causing typical presenting behaviours. These results suggest that TBM might be useful in tracking progression of regional atrophy in FTD.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Brambati SM,Renda NC,Rankin KP,Rosen HJ,Seeley WW,Ashburner J,Weiner MW,Miller BL,Gorno-Tempini MLdoi
10.1016/j.neuroimage.2007.01.028subject
Has Abstractpub_date
2007-04-15 00:00:00pages
998-1003issue
3eissn
1053-8119issn
1095-9572pii
S1053-8119(07)00094-8journal_volume
35pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract:OBJECTIVE:The dopamine D2/3 receptor subtypes (DRD2/3) are the most widely studied neurotransmitter biomarker in research on obesity, but results to date have been inconsistent, have typically involved small samples, and have rarely accounted for subjects' ages despite the large impact of age on DRD2/3 levels. We aimed...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.05.044
更新日期:2016-09-01 00:00:00
abstract::Macroscopic models of brain networks typically incorporate assumptions regarding the characteristics of afferent noise, which is used to represent input from distal brain regions or ongoing fluctuations in non-modelled parts of the brain. Such inputs are often modelled by Gaussian white noise which has a flat power sp...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.11.034
更新日期:2017-02-01 00:00:00
abstract::In recent studies it has been shown that temporal predictability of expected events alters processing in perception and action. Yet, the neural mechanism(s) by which temporal predictability biases this processing is to date little understood. Therefore, in the present fMRI study we investigated how temporal predictabi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.10.091
更新日期:2013-02-01 00:00:00
abstract::Humans and many animals can distinguish between stimuli that differ in numerosity, the number of objects in a set. Human and macaque parietal lobes contain neurons that respond to changes in stimulus numerosity. However, basic non-numerical visual features can affect neural responses to and perception of numerosity, a...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.02.012
更新日期:2017-04-01 00:00:00
abstract::Scientists and clinicians have traditionally targeted single brain regions with stimulation to modulate brain function and disease. However, brain regions do not operate in isolation, but interact with other regions through networks. As such, stimulation of one region may impact and be impacted by other regions in its...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.05.060
更新日期:2017-08-15 00:00:00
abstract::The timing of slow auditory cortical activity aligns to the rhythmic fluctuations in speech. This entrainment is considered to be a marker of the prosodic and syllabic encoding of speech, and has been shown to correlate with intelligibility. Yet, whether and how auditory cortical entrainment is influenced by the activ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.11.062
更新日期:2017-02-15 00:00:00
abstract::Competition enhances learning under certain circumstances. However, little is known about how the neural mechanisms involved in a competition during the episodic encoding are modulated by the social distance of personal relationships with opponents. To investigate this issue, using functional magnetic resonance imagin...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.02.020
更新日期:2016-04-15 00:00:00
abstract:AIMS:Using functional magnetic resonance imaging (fMRI) we investigated the cortical and subcortical representations during bladder filling and the effect of simultaneous stimulation of the dorsal clitoral nerve on these cortical and subcortical structures. METHODS:After approval of the local ethics committee, 8 healt...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.03.006
更新日期:2008-07-01 00:00:00
abstract::Allocation of attentional resources to portions of the available sensory input can be regulated by bottom-up processes, i.e., spontaneous orientation towards an oncoming stimulus (stimulus-driven attention), and by top-down processes, i.e., intentionally and driven by knowledge, expectation and goals. The present stud...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.04.177
更新日期:2006-08-15 00:00:00
abstract::BOLD fMRI localizes activated brain areas by measuring decreases of deoxygenated hemoglobin (deoxy-Hb) caused by neurovascular coupling. To date, it is unclear whether intracranial pressure (ICP) modifies deoxy-Hb signaling for brain mapping. In addition, ICP elevation can test whether the BOLD post-stimulus undershoo...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.04.237
更新日期:2010-08-15 00:00:00
abstract:PURPOSE:Evaluate brain iron accumulation in alcohol use disorder (AUD) patients compared to controls using quantitative susceptibility mapping (QSM). METHODS:QSM was performed retrospectively by using phase images from resting state functional magnetic resonance imaging (fMRI). 20 male AUD patients and 15 matched heal...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.01.007
更新日期:2017-03-01 00:00:00
abstract::It is generally believed that alpha band (8-12 Hz) electric and magnetic activity in the area of the left and right temporal regions in the human brain are at best poorly correlated. There are no previous reports of very high alpha band correlation between left and right temporal regions by magnetoencephalography (MEG...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.04.016
更新日期:2004-08-01 00:00:00
abstract::The finding of a multisensory representation of actions in a premotor area of the monkey brain suggests that similar multimodal action-matching mechanisms may also be present in humans. Based on the existence of an audiovisual mirror system, we investigated whether sounds referring to actions that can be performed by ...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroimage.2004.09.025
更新日期:2005-02-01 00:00:00
abstract::For many years now, Magnetic Resonance Innovations (MR Innovations), a magnetic resonance imaging (MRI) software development, technology, and research company, has been aggregating a multitude of MRI data from different scanning sites through its collaborations and research contracts. The majority of the data has adhe...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.04.066
更新日期:2016-01-01 00:00:00
abstract::The cortical microvessels are organized in an intricate, hierarchical, three-dimensional network. Superimposed on this anatomical complexity is the highly complicated signaling that drives the focal blood flow adjustments following a rise in the activity of surrounding neurons. The microvascular response to neuronal a...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.01.011
更新日期:2013-05-01 00:00:00
abstract::The diffusion tensor is a commonly used model for diffusion-weighted MR image data. The parameters are typically estimated by ordinary or weighted least squares on log-transformed data, assuming normal or log-normal distribution of measurement errors respectively. This may not be adequate when using high b-values and ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.05.053
更新日期:2008-10-01 00:00:00
abstract::We demonstrate the capacity of dynamic causal modeling to characterize the nonlinear coupling among cortical sources that underlie time-frequency modulations in MEG data. Our experimental task involved the mental rotation of hand drawings that ten subjects used to decide if it was a right or left hand. Reaction times ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.12.076
更新日期:2013-05-01 00:00:00
abstract::Clinical and preclinical evidence suggests anxiolytic-like efficacy of pregabalin (PGB, Lyrica). However, its mechanism of action remains under investigation. The current study applied [(14)C]-iodoantipyrine cerebral blood flow (CBF) mapping to examine the effect of PGB on neural substrates underlying unconditioned fe...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.11.047
更新日期:2012-02-15 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) is an important tool for noninvasively imaging the hemodynamic responses accompanying brain activity, but fMRI measurements are accompanied by loud acoustic noises resulting from Lorentz forces that cannot be completely excluded when the present technology is used. We used ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.04.197
更新日期:2006-08-15 00:00:00
abstract::Some cross-sectional studies suggest reduced cerebellar volumes with aging, but there have been few longitudinal studies of age changes in cerebellar subregions in cognitively healthy older adults. In this work, 2,023 magnetic resonance (MR) images of 822 cognitively normal participants from the Baltimore Longitudinal...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117062
更新日期:2020-10-15 00:00:00
abstract::Current neurobiological models assign a central role to predictive processes calibrated to environmental statistics. Neuroimaging studies examining the encoding of stimulus uncertainty have relied almost exclusively on manipulations in which stimuli were presented in a single sensory modality, and further assumed that...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.02.019
更新日期:2018-06-01 00:00:00
abstract::In humans, each hemisphere comprises an overlay of two visuotopic maps of the contralateral visual field, one from each eye. Is the capacity of the visual cortex limited to these two maps or are plastic mechanisms available to host more maps? We determined the cortical organization of the visual field maps in a rare i...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.116822
更新日期:2020-07-15 00:00:00
abstract::Supra-spinal pain processing involves a number of extensive networks. An examination of these networks using small animal functional magnetic resonance imaging (fMRI) is difficult. While prior studies have successfully delineated regions consistent with known pain processing pathways, they have been restricted to acqu...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.12.014
更新日期:2007-04-01 00:00:00
abstract::Connectivity is fundamental for understanding the nature of brain function. The intricate web of synaptic connections among neurons is critically important for shaping neural responses, representing statistical features of the sensory environment, coordinating distributed resources for brain-wide processing, and retai...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2011.08.085
更新日期:2012-08-15 00:00:00
abstract::Extracellular β-amyloid (Aβ) plaque deposits and inflammatory immune activation are thought to alter various aspects of tissue microstructure, such as extracellular free water, fractional anisotropy and diffusivity, as well as the density and geometric arrangement of axonal processes. Quantifying these microstructural...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116138
更新日期:2019-11-15 00:00:00
abstract::Using event-related brain potentials, we investigated the temporal course of language change detection in proficient bilinguals as compared to matched controls. Welsh-English bilingual participants and English controls were presented with a variant of the oddball paradigm involving picture-word pairs. The language of ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.01.076
更新日期:2010-05-01 00:00:00
abstract::The human visual system is able to distinguish naturally occurring categories with exceptional speed and accuracy. At the same time, it exhibits substantial plasticity, permitting the seamless and fast learning of entirely novel categories. Here we investigate the interplay of these two processes by asking how categor...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.03.066
更新日期:2016-07-01 00:00:00
abstract::When a head is placed in an MRI scanner, differences between the magnetic susceptibility of tissue, bone, and air distort the magnetic field. While some of the resulting inhomogeneity can be corrected by the shimming process, much of it cannot, and this causes distortion (sometimes referred to as geometric distortion)...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2002.1281
更新日期:2003-01-01 00:00:00
abstract::T1 mapping lacks specificity toward a single particular biological feature, however it has the potential to discriminate spinal cord regional tissue organization and characterize tissue microstructural impairments occurring in neurodegenerative pathologies. In this exploratory work, T1 mapping of the cervical spinal c...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116275
更新日期:2020-01-15 00:00:00
abstract::We describe the Cambridge animal brain magnetic resonance imaging repository comprising 400 datasets to date from mouse models of Huntington disease. The data include raw images as well as segmented grey and white matter images with maps of cortical thickness. All images and phenotypic data for each subject are freely...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.04.056
更新日期:2016-01-01 00:00:00