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Deep grey matter iron accumulation in alcohol use disorder.

Abstract：

PURPOSE:Evaluate brain iron accumulation in alcohol use disorder (AUD) patients compared to controls using quantitative susceptibility mapping (QSM). METHODS:QSM was performed retrospectively by using phase images from resting state functional magnetic resonance imaging (fMRI). 20 male AUD patients and 15 matched healthy controls were examined. Susceptibility values were manually traced in deep grey matter regions including caudate nucleus, combined putamen and globus pallidus, combined substantia nigra and red nucleus, dentate nucleus, and a reference white matter region in the internal capsule. Average susceptibility values from each region were compared between the patients and controls. The relationship between age and susceptibility was also explored. RESULTS:The AUD group exhibited increased susceptibility in caudate nucleus (+8.5%, p=0.034), combined putamen and globus pallidus (+10.8%, p=0.006), and dentate nucleus (+14.9%, p=0.022). Susceptibility increased with age in two of the four measured regions - combined putamen and globus pallidus (p=0.013) and combined substantia nigra and red nucleus (p=0.041). AUD did not significantly modulate the rate of susceptibility increase with age in our data. CONCLUSION:Retrospective QSM computed from standard fMRI datasets provides new opportunities for brain iron studies in psychiatry. Substantially elevated brain iron was found in AUD subjects in the basal ganglia and dentate nucleus. This was the first human AUD brain iron study and the first retrospective clinical fMRI QSM study.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Juhás M,Sun H,Brown MRG,MacKay MB,Mann KF,Sommer WH,Wilman AH,Dursun SM,Greenshaw AJ

doi

10.1016/j.neuroimage.2017.01.007

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

115-122

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(17)30007-1

journal_volume

148

pub_type

杂志文章

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