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Diffusion imaging of whole, post-mortem human brains on a clinical MRI scanner.

Abstract：

:Diffusion imaging of post mortem brains has great potential both as a reference for brain specimens that undergo sectioning, and as a link between in vivo diffusion studies and "gold standard" histology/dissection. While there is a relatively mature literature on post mortem diffusion imaging of animals, human brains have proven more challenging due to their incompatibility with high-performance scanners. This study presents a method for post mortem diffusion imaging of whole, human brains using a clinical 3-Tesla scanner with a 3D segmented EPI spin-echo sequence. Results in eleven brains at 0.94 × 0.94 × 0.94 mm resolution are presented, and in a single brain at 0.73 × 0.73 × 0.73 mm resolution. Region-of-interest analysis of diffusion tensor parameters indicate that these properties are altered compared to in vivo (reduced diffusivity and anisotropy), with significant dependence on post mortem interval (time from death to fixation). Despite these alterations, diffusion tractography of several major tracts is successfully demonstrated at both resolutions. We also report novel findings of cortical anisotropy and partial volume effects.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Miller KL,Stagg CJ,Douaud G,Jbabdi S,Smith SM,Behrens TEJ,Jenkinson M,Chance SA,Esiri MM,Voets NL,Jenkinson N,Aziz TZ,Turner MR,Johansen-Berg H,McNab JA

doi

10.1016/j.neuroimage.2011.03.070

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

167-181

issue

1

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(11)00349-1

journal_volume

57

pub_type

杂志文章

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