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Disconnectivity of the cortical ocular motor control network in autism spectrum disorders.

Abstract：

:Response inhibition, or the suppression of prepotent but contextually inappropriate behaviors, is essential to adaptive, flexible responding. Individuals with autism spectrum disorders (ASD) consistently show deficient response inhibition during antisaccades. In our prior functional MRI study, impaired antisaccade performance was accompanied by reduced functional connectivity between the frontal eye field (FEF) and dorsal anterior cingulate cortex (dACC), regions critical to volitional ocular motor control. Here we employed magnetoencephalography (MEG) to examine the spectral characteristics of this reduced connectivity. We focused on coherence between FEF and dACC during the preparatory period of antisaccade and prosaccade trials, which occurs after the presentation of the task cue and before the imperative stimulus. We found significant group differences in alpha band mediated coherence. Specifically, neurotypical participants showed significant alpha band coherence between the right inferior FEF and right dACC and between the left superior FEF and bilateral dACC across antisaccade, prosaccade, and fixation conditions. Relative to the neurotypical group, ASD participants showed reduced coherence between these regions in all three conditions. Moreover, while neurotypical participants showed increased coherence between the right inferior FEF and the right dACC in preparation for an antisaccade compared to a prosaccade or fixation, ASD participants failed to show a similar increase in preparation for the more demanding antisaccade. These findings demonstrate reduced long-range functional connectivity in ASD, specifically in the alpha band. The failure in the ASD group to increase alpha band coherence with increasing task demand may reflect deficient top-down recruitment of additional neural resources in preparation to perform a difficult task.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Kenet T,Orekhova EV,Bharadwaj H,Shetty NR,Israeli E,Lee AK,Agam Y,Elam M,Joseph RM,Hämäläinen MS,Manoach DS

doi

10.1016/j.neuroimage.2012.03.010

subject

Has Abstract

pub_date

2012-07-16 00:00:00

pages

1226-34

issue

4

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(12)00282-0

journal_volume

61

pub_type

杂志文章

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